Protein Alignment CG45062 and ATP2B2

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_001001331.1
• Gene: ATP2B2 / 491
• HGNCID: 815
• Length: 1243
• Species: Homo sapiens
• Alignment Length: 836
• Identity: 186/836 - (22%)
• Similarity: 334/836 - (39%)
• Gaps: 194/836 - (23%)

  Fly    35 RNTEVGSMTDLCFKERSRSRSQKHQKQIS-----------------YYMLLVAIVCFILLFLTTG 82
            ::.|.|...|       |.::..|:|:.|                 ..|..:.::..:|.|....
Human   363 KSAEGGDADD-------RKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDT 420

  Fly    83 FEHG-----------HIVYEVNLSLLIGLT------PVYLPFILYWGLRRTRKEMGRKQCHVRNL 130
            |...           ::.|.|.. .:||:|      |..||..:...|..:.|:|.:....||:|
Human   421 FVVNKKPWLPECTPVYVQYFVKF-FIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL 484

  Fly   131 RATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV-DMGLLSVDNLDVSAQSPRFIELIRASVLCNDA 194
            .|..|:|.:|.|.||..||:|..||.|.:.:| |:....:.  |.|:.:.:.:||:..::..|.|
Human   485 DACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIP--DPSSINTKTMELLINAIAINSA 547

  Fly   195 ----VICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANK----------HY 245
                ::.|...|....|   .||..:..||.|.|.       |:.|:|.|.::          .:
Human   548 YTTKILPPEKEGALPRQ---VGNKTECGLLGFVLD-------LKQDYEPVRSQMPEEKLYKVYTF 602

  Fly   246 NSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRC----------STFAIRDEELPLDEQLQE 300
            ||..|...||.:..|.    ...:..||..|:|:::|          ..|..||.    ||.:::
Human   603 NSVRKSMSTVIKLPDE----SFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDR----DEMVKK 659

  Fly   301 IILSLA-DGLLEAGRHVRAFAYKEL--SDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLG 362
            :|..:| |||     .....||::.  |.|.::...:.:                  ...|..:.
Human   660 VIEPMACDGL-----RTICVAYRDFPSSPEPDWDNENDI------------------LNELTCIC 701

  Fly   363 MIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPT 427
            ::...:|.|..:|:|:.:|:.|||.:.:||......|:|:|:..||: .|.:.|..:..|..
Human   702 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGII-HPGEDFLCLEGKEF--- 762

  Fly   428 AEVVDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQ---LHWIADACR-RLGAVVSVIGGT 488
                 ..:..:||.:.::..|:: |..:..::..::.||:   :..|.|:.. ....||:|.|..
Human   763 -----NRRIRNEKGEIEQERIDK-IWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDG 821

  Fly   489 LHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLAT 551
            .:|.||::.:.||.|.  .|:.|..||| |:||.|.:|:::|..|...|.:::::.|.|.:.|..
Human   822 TNDGPALKKADVGFAMGIAGTDVAKEAS-DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTV 885

  Fly   552 NICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPKVYDDFLLNSR 616
            |:..::|......:.....:..:..|.:..:::...:|.|..|||.|.|:|:.|...:..|::..
Human   886 NVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRT 950

  Fly   617 LFFVSHILVGTI-EAAAVFMTYFV----FMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSS 676
            :  :.:||...: :.|.:|...||    |..|.|        .|...|....:..|..|.
Human   951 M--MKNILGHAVYQLALIFTLLFVGEKMFQIDSG--------RNAPLHSPPSEHYTIIFN----- 1000

  Fly   677 EARRQLECQVSSLCLMSLAVMQCTNLVLTKT--GRANLLAHGFRNWLLSLAVLLLICLCVQLCIM 739
                            :..:||..|.:..:.  |..|:....|||.:  ...::|....:|:.|:
Human  1001 ----------------TFVMMQLFNEINARKIHGERNVFDGIFRNPI--FCTIVLGTFAIQIVIV 1047

  Fly   740 D------STVCLRLE--------GTNELHFGHFLLTNCPFMILLVFIETTRRYFIR 781
            .      |...|:|:        |..||.:|..:.|          |.|:|..|::
Human  1048 QFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIAT----------IPTSRLKFLK 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	186/836 (22%)
ATP2B2	NP_001001331.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		ATPase-IIB_Ca	12..1087	CDD:273668	183/828 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..381		5/24 (21%)
		Calmodulin-binding subdomain A. /evidence=ECO:0000250	1123..1140
		ATP_Ca_trans_C	1126..1172	CDD:463575
		Calmodulin-binding subdomain B. /evidence=ECO:0000250	1141..1150
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1194..1243