DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and ATP2B1

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_001353453.1	Gene:	ATP2B1 / 490	HGNCID:	814	Length:	1249	Species:	Homo sapiens

Alignment Length:	748	Identity:	159/748 - (21%)
Similarity:	301/748 - (40%)	Gaps:	187/748 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LACTHAISGIGFAVALACGRNTEVG-------------------------SMTDLCFKERSRSRS 55
            |:.||.:.|.|..|..|.|.|::.|                         ...|...:.|:::::
Human   261 LSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKA 325

  Fly    56 Q-----------------------------KHQKQI---------------SYYMLLVAIVCFIL 76
            |                             |.:|.:               ...|..:.::..:|
Human   326 QDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVL 390

  Fly    77 LFLTTGF----------------EHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQC 125
            .|:...|                ::....:.:.:::|:...|..||..:...|..:.|:|.:...
Human   391 YFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNN 455

  Fly   126 HVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV-DMGLLSVDNLDVSAQSPRFIELIRASV 189
            .||:|.|..|:|.:|.|.||..||:|..||.|.:.:: :.....|.  :..|..|..:..:...:
Human   456 LVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVP--EPEAIPPNILSYLVTGI 518

  Fly   190 LCNDA----VICPGNI-GVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANK------ 243
            ..|.|    ::.|... |:|:    ..||..:.|||  ||:    :||.| |::.|.|:
Human   519 SVNCAYTSKILPPEKEGGLPR----HVGNKTECALL--GLL----LDLKR-DYQDVRNEIPEEAL 572

  Fly   244 ----HYNSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRC----------STFAIRDEELPL 294
                .:||..|...||  .:::||..:  :..||..|:::::|          ..|..||.:
Human   573 YKVYTFNSVRKSMSTV--LKNSDGSYR--IFSKGASEIILKKCFKILSANGEAKVFRPRDRD--- 630

  Fly   295 DEQLQEIILSLADGLLEAGRHVRAFAYKEL---SDELEFRRFSQVNTGLEGGEYKYRDYLAVDTY 356
                 :|:.::.:.:...|......|:::.   ..|.|:...:.:.||
Human   631 -----DIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTG----------------- 673

  Fly   357 SLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNL 421
             |..:.::...:|.|..:|.|:.:|:.|||.:.:||......|:|:|...||| .|.:.|..:..
Human   674 -LTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIL-HPGEDFLCLEG 736

  Fly   422 KRMPPTAEVVDMS-QYADEKPQHQRRHIEQLILNQQDLVCAATSTDQ---LHWIADAC---RRLG 479
            |         |.: :..:||.:.::..|:: |..:..::..::.||:   :..|.|:.   :|
Human   737 K---------DFNRRIRNEKGEIEQERIDK-IWPKLRVLARSSPTDKHTLVKGIIDSTVSDQR-- 789

  Fly   480 AVVSVIGGTLHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLK 542
            .||:|.|...:|.||::.:.||.|.  .|:.|..||| |:||.|.:|.::|..|...|.:::::.
Human   790 QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS-DIILTDDNFTSIVKAVMWGRNVYDSIS 853

  Fly   543 KALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPKV 607
            |.|.:.|..|:..::|......:.....:..:..|.:..:::.:.:|.|..|||.|:|:|:.|
Human   854 KFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKP-- 916

  Fly   608 YDDFLLNSRLFFVSHILVGTIEAAAVFMTYFVF 640
               :..|..|  :|..::..|...|.:....||
Human   917 ---YGRNKPL--ISRTMMKNILGHAFYQLVVVF 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	29/200 (15%)
		Cation_ATPase	190..284	CDD:289987	29/118 (25%)
		Cation_ATPase_C	582..777	CDD:295563	16/59 (27%)
ATP2B1	NP_001353453.1	ATPase-IIB_Ca	15..1064	CDD:273668	159/748 (21%)
ATP2B1	NP_001353453.1	ATP_Ca_trans_C	1103..1178	CDD:403580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930