Protein Alignment CG45062 and ATP2A2

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_733765.1
• Gene: ATP2A2 / 488
• HGNCID: 812
• Length: 1042
• Species: Homo sapiens
• Alignment Length: 919
• Identity: 202/919 - (21%)
• Similarity: 375/919 - (40%)
• Gaps: 232/919 - (25%)

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTD-LCFKERSRSRSQKHQKQISYYM-LLVAIVCFI 75
            ||..:.|:..:|....|.:|.|.|||:|.:.| :...|:.|:..|:...:....: .:::::|..
Human   206 NMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA 270

  Fly    76 LLFLTTG----------FEHGHIVY-EVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRN 129
            :..:..|          :..|.|.| ::.::|.:...|..||.::...|....:.|.:|...||:
Human   271 VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS 335

  Fly   130 LRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV----------------------DMGLLSVDNL 172
            |.:..|||.::||.||..||:|..:|.|..:|:                      .:|.:..|:.
Human   336 LPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDK 400

  Fly   173 DVSA-QSPRFIELIRASVLCNDAVI----CPG---NIG----------VPKMQKDMYGNILDIAL 219
            .|:. |....:||.....||||:.:    ..|   .:|          |.||      |:.|..|
Human   401 PVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM------NVFDTEL 459

  Fly   220 LKFGLMILPSIDLLRHDHEKVANKHYN---SEDKVQVTVHRTRDADGHLKL-VLLMKGHCEVVIR 280
            .  ||..:...:......:::..|.:.   |.|:..::|:.|.:......: .:.:||..|.||.
Human   460 K--GLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVID 522

  Fly   281 RCSTFAIRDEELPLDEQLQEIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEY 345
            ||:...:...::|:...:::.|:|:   :.|.|..         ||.|.....:..:..|...|.
Human   523 RCTHIRVGSTKVPMTSGVKQKIMSV---IREWGSG---------SDTLRCLALATHDNPLRREEM 575

  Fly   346 KYRD---YLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVG 407
            ...|   ::..:| :|.|:|.:...:|||..:..:|..||.|||::|::|......|.|:...:|
Human   576 HLEDSANFIKYET-NLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIG 639

  Fly   408 ILPAPSD----TFQAVNLKRMPPTAE---VVDMSQYADEKPQHQRRHIEQLILNQQDLVCAATST 465
            |.....|    .|.......:.|:|:   .::...:|..:|.|:.:.:|.|           .|.
Human   640 IFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFL-----------QSF 693

  Fly   466 DQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVMCEASADLILLDTSFATLVSV 530
            |:             :.::.|..::|.||::.:.:|:|......:.:.:::::|.|.:|:|:|:.
Human   694 DE-------------ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAA 745

  Fly   531 VGDSRLLFENLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFL--VNLV----PAL 589
            |.:.|.::.|:|:.:.|.:::|:..::.......||.|      :.||...|  ||||    ||.
Human   746 VEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFP------EALIPVQLLWVNLVTDGLPAT 804

  Fly   590 TLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILVG------TIEAAAVFMTYFVFMADKG--- 645
            .|.:.||:.::|.:.|:...:.|::..||| .::.:|      |:.|||    ::...||.|
Human   805 ALGFNPPDLDIMNKPPRNPKEPLISGWLFF-RYLAIGCYVGAATVGAAA----WWFIAADGGPRV 864

  Fly   646 -------FL---------------------PRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQL 682
                   ||                     |.|: ||::....:|.:.:..      .||.:..|
Human   865 SFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTM-ALSVLVTIEMCNALNS------LSENQSLL 922

  Fly   683 ECQ-------VSSLCL-MSL-----------AVMQCTNLVLTKTGRANLLAHGFRNWLLSLAVLL 728
            ...       |.|:|| |||           .:.|.|.|.:|:             ||:.|.:.|
Human   923 RMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQ-------------WLMVLKISL 974

  Fly   729 LICLCVQLCIMDSTVCLRLEGTNELHFGHFLL----TNC-----------PFMILL----VFIET 774
            .:.|      ||.|  |:....|.|..|...:    .:|           ||::|:    :::.:
Human   975 PVIL------MDET--LKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVIWVYS 1031

  Fly   775 TRRYFIRLF 783
            |...|..:|
Human  1032 TDTNFSDMF 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	202/919 (22%)
ATP2A2	NP_733765.1	P-type_ATPase_SERCA	5..988	CDD:319778	192/865 (22%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:18971376	575..594		4/19 (21%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	787..807		8/19 (42%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000250|UniProtKB:O55143	788..1042		64/286 (22%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	931..942		5/10 (50%)