Protein Alignment CG45062 and ATP2A1

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_775293.1
• Gene: ATP2A1 / 487
• HGNCID: 811
• Length: 1001
• Species: Homo sapiens
• Alignment Length: 874
• Identity: 184/874 - (21%)
• Similarity: 353/874 - (40%)
• Gaps: 209/874 - (23%)

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTD-LCFKERSRSRSQKHQKQISYYM-LLVAIVCFI 75
            ||..:.|:..:|....:....|..||:|.:.| :...|:.::..|:...:....: .:::::|..
Human   206 NMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVA 270

  Fly    76 LLFLTTG----------FEHGHIVY-EVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRN 129
            :..:..|          :..|.|.| ::.::|.:...|..||.::...|....:.|.:|...||:
Human   271 VWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS 335

  Fly   130 LRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV------DMGLLSVDNLDVSAQSPR-------- 180
            |.:..|||.::||.||..||:|..:|.|.::|:      |:.||:..::..|..:|.
Human   336 LPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDK 400

  Fly   181 ---------FIELIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALL----KFGLMILPSIDL 232
                     .:||.....||||:.:   :....|...:..|...:.||.    |..:.......|
Human   401 PVRPGQYDGLVELATICALCNDSSL---DFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSL 462

  Fly   233 LRHDHEKVAN--------KHYN---SEDKVQVTVH-----RTRDADGHLKLVLLMKGHCEVVIRR 281
            .:.:.....|        |.:.   |.|:..::|:     .:|.|.|:   .:.:||..|.||.|
Human   463 SKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGN---KMFVKGAPEGVIDR 524

  Fly   282 CSTFAIRDEELPLDEQLQEIILSLADGLLE--AGRHVRAFAYKELSDELEFRRFSQVNTGLEGGE 344
            |:...:....:||...::|.|:::   :.|  .||           |.|.....:..:|..:..|
Human   525 CNYVRVGTTRVPLTGPVKEKIMAV---IKEWGTGR-----------DTLRCLALATRDTPPKREE 575

  Fly   345 YKYRD---YLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDV 406
            ....|   :|..:| .|.|:|::...:|||..:..::..||.|||::|::|......|.|:...:
Human   576 MVLDDSARFLEYET-DLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRI 639

  Fly   407 GILPAPSDTFQAVNLKRM---PPTAEVVDMSQ----YADEKPQHQRRHIEQLILNQQDLVCAATS 464
            ||.....:........|.   .|.||..:..:    :|..:|.|:.:.:|.|           .|
Human   640 GIFGENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYL-----------QS 693

  Fly   465 TDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVMCEASADLILLDTSFATLVS 529
            .|:             :.::.|..::|.||::.:.:|:|......:.:.:::::|.|.:|:|:|:
Human   694 YDE-------------ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVA 745

  Fly   530 VVGDSRLLFENLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFL--VNLV----PA 588
            .|.:.|.::.|:|:.:.|.:::|:..::.......||:|      :.||...|  ||||    ||
Human   746 AVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLP------EALIPVQLLWVNLVTDGLPA 804

  Fly   589 LTLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILVG------TIEAAAVFMTYFVFMADKG-- 645
            ..|.:.||:.::|.:.|:...:.|::..||| .::.:|      |:.|||.:..|    |:.|
Human   805 TALGFNPPDLDIMDRPPRSPKEPLISGWLFF-RYMAIGGYVGAATVGAAAWWFLY----AEDGPH 864

  Fly   646 --------FLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLECQV------SSLCLMSLAV 696
                    |:..|             :|.|...|          ::|:|      .::.|..|..
Human   865 VNYSQLTHFMQCT-------------EDNTHFEG----------IDCEVFEAPEPMTMALSVLVT 906

  Fly   697 MQCTNLVLTKTGRANLL--AHGFRNWLLSLAVLLLICLCVQLCIMDSTVCLRLEGTNELHFGHFL 759
            ::..|.:.:.:...:||  ......|||                  .::||.:    .|||....
Human   907 IEMCNALNSLSENQSLLRMPPWVNIWLL------------------GSICLSM----SLHFLILY 949

  Fly   760 LTNCPFMILLVFIETTRRYFIRLFPDSWL 788
            :...|.:..|..::.|:          ||
Human   950 VDPLPMIFKLRALDLTQ----------WL 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	184/874 (21%)
ATP2A1	NP_775293.1	P-type_ATPase_SERCA	5..989	CDD:319778	184/874 (21%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	788..808		8/19 (42%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	932..943		5/32 (16%)