DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and ATP2A1

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_775293.1	Gene:	ATP2A1 / 487	HGNCID:	811	Length:	1001	Species:	Homo sapiens

Alignment Length:	874	Identity:	184/874 - (21%)
Similarity:	353/874 - (40%)	Gaps:	209/874 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTD-LCFKERSRSRSQKHQKQISYYM-LLVAIVCFI 75
            ||..:.|:..:|....:....|..||:|.:.| :...|:.::..|:...:....: .:::::|..
Human   206 NMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVA 270

  Fly    76 LLFLTTG----------FEHGHIVY-EVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRN 129
            :..:..|          :..|.|.| ::.::|.:...|..||.::...|....:.|.:|...||:
Human   271 VWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS 335

  Fly   130 LRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV------DMGLLSVDNLDVSAQSPR-------- 180
            |.:..|||.::||.||..||:|..:|.|.::|:      |:.||:..::..|..:|.
Human   336 LPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDK 400

  Fly   181 ---------FIELIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALL----KFGLMILPSIDL 232
                     .:||.....||||:.:   :....|...:..|...:.||.    |..:.......|
Human   401 PVRPGQYDGLVELATICALCNDSSL---DFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSL 462

  Fly   233 LRHDHEKVAN--------KHYN---SEDKVQVTVH-----RTRDADGHLKLVLLMKGHCEVVIRR 281
            .:.:.....|        |.:.   |.|:..::|:     .:|.|.|:   .:.:||..|.||.|
Human   463 SKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGN---KMFVKGAPEGVIDR 524

  Fly   282 CSTFAIRDEELPLDEQLQEIILSLADGLLE--AGRHVRAFAYKELSDELEFRRFSQVNTGLEGGE 344
            |:...:....:||...::|.|:::   :.|  .||           |.|.....:..:|..:..|
Human   525 CNYVRVGTTRVPLTGPVKEKIMAV---IKEWGTGR-----------DTLRCLALATRDTPPKREE 575

  Fly   345 YKYRD---YLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDV 406
            ....|   :|..:| .|.|:|::...:|||..:..::..||.|||::|::|......|.|:...:
Human   576 MVLDDSARFLEYET-DLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRI 639

  Fly   407 GILPAPSDTFQAVNLKRM---PPTAEVVDMSQ----YADEKPQHQRRHIEQLILNQQDLVCAATS 464
            ||.....:........|.   .|.||..:..:    :|..:|.|:.:.:|.|           .|
Human   640 GIFGENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYL-----------QS 693

  Fly   465 TDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVMCEASADLILLDTSFATLVS 529
            .|:             :.::.|..::|.||::.:.:|:|......:.:.:::::|.|.:|:|:|:
Human   694 YDE-------------ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVA 745

  Fly   530 VVGDSRLLFENLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFL--VNLV----PA 588
            .|.:.|.::.|:|:.:.|.:::|:..::.......||:|      :.||...|  ||||    ||
Human   746 AVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLP------EALIPVQLLWVNLVTDGLPA 804

  Fly   589 LTLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILVG------TIEAAAVFMTYFVFMADKG-- 645
            ..|.:.||:.::|.:.|:...:.|::..||| .::.:|      |:.|||.:..|    |:.|
Human   805 TALGFNPPDLDIMDRPPRSPKEPLISGWLFF-RYMAIGGYVGAATVGAAAWWFLY----AEDGPH 864

  Fly   646 --------FLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLECQV------SSLCLMSLAV 696
                    |:..|             :|.|...|          ::|:|      .::.|..|..
Human   865 VNYSQLTHFMQCT-------------EDNTHFEG----------IDCEVFEAPEPMTMALSVLVT 906

  Fly   697 MQCTNLVLTKTGRANLL--AHGFRNWLLSLAVLLLICLCVQLCIMDSTVCLRLEGTNELHFGHFL 759
            ::..|.:.:.:...:||  ......|||                  .::||.:    .|||....
Human   907 IEMCNALNSLSENQSLLRMPPWVNIWLL------------------GSICLSM----SLHFLILY 949

  Fly   760 LTNCPFMILLVFIETTRRYFIRLFPDSWL 788
            :...|.:..|..::.|:          ||
Human   950 VDPLPMIFKLRALDLTQ----------WL 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	26/131 (20%)
		Cation_ATPase	190..284	CDD:289987	25/113 (22%)
		Cation_ATPase_C	582..777	CDD:295563	47/224 (21%)
ATP2A1	NP_775293.1	Cation_ATPase_N	4..72	CDD:279080
		ATPase-IIA1_Ca	53..989	CDD:273452	184/874 (21%)
		E1-E2_ATPase	93..340	CDD:278548	26/133 (20%)
		Cation_ATPase	419..528	CDD:289987	25/114 (22%)
		HAD	<611..712	CDD:289480	26/124 (21%)
		Cation_ATPase_C	784..987	CDD:279079	52/251 (21%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	788..808		8/19 (42%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	932..943		5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141073
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42861
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940