Protein Alignment CG45062 and ATP1A4

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_653300.2
• Gene: ATP1A4 / 480
• HGNCID: 14073
• Length: 1029
• Species: Homo sapiens
• Alignment Length: 822
• Identity: 263/822 - (31%)
• Similarity: 421/822 - (51%)
• Gaps: 81/822 - (9%)

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFKERSRSRSQKHQ----KQISYYMLLVAIVC 73
            |:....|:.:.|....:.:|.|.:|.:|.:..|      .|.....|    .:|.:::.|:.:|.
Human   249 NICFFSTNCVEGTARGIVIATGDSTVMGRIASL------TSGLAVGQTPIAAEIEHFIHLITVVA 307

  Fly    74 ------FILLFLTTG--------FEHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQ 124
                  |..|.|..|        |..|.||..|...||..:|..         |..|.|.|.||.
Human   308 VFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVC---------LTLTAKRMARKN 363

  Fly   125 CHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLD------VSAQSPRFIE 183
            |.|:||.|..|||.::.|.||..||:|:.||.|:.::.||.:...|..:      .:..|..:..
Human   364 CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFTKSSDTWFM 428

  Fly   184 LIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSE 248
            |.|.:.|||.|........:|..::...|:..:.|||||......|:..:|..:.|||...:||.
Human   429 LARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPFNST 493

  Fly   249 DKVQVTVHRTRD-ADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQEIILSLADGLLEA 312
            :|.|:::|...| :..|   ||:|||..|.::..||||.:..:|..::::::|...:....|...
Human   494 NKYQMSIHLREDSSQTH---VLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGL 555

  Fly   313 GRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKA 377
            |..|..|.:..|..  .|.:....||          |.:.....:|.|:|:|:..:|||:.:|.|
Human   556 GERVLGFCFLNLPS--SFSKGFPFNT----------DEINFPMDNLCFVGLISMIDPPRAAVPDA 608

  Fly   378 VDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEVVDMSQ------Y 436
            |.:||:||||:|:||...|..|||:|..|||:...::|.:.|..:...|.:: ||.|.      :
Human   609 VSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISK-VDASAAKAIVVH 672

  Fly   437 ADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVG 501
            ..|....|.:.::|::.|..::|.|.||..|...|.:.|:||||||:|.|..::|:||::.:.:|
Human   673 GAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIG 737

  Fly   502 VAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVYLFFFL 564
            :|.  .||.|..:| ||:||||.:||::|:.|.:.||:|:||||::.|.|.:||..|..:|.|.:
Human   738 IAMGISGSDVSKQA-ADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFII 801

  Fly   565 LGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VYDDFLLNSRLFFVSHILVGTI 628
            |||||.:..:..|.:....::|||::|.||..|.::|.::|: ...|.|:|.||..:::..:|.|
Human   802 LGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMI 866

  Fly   629 EAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLECQVSSLCLMS 693
            :|.|.|.||||.:|:.||.|..|:.:.:.|.|..|:|:.||:||:|:.|.|:.:|....:...::
Human   867 QALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVT 931

  Fly   694 LAVMQCTNLVLTKTGRANLLAHGFRNWLLSLAVL---LLICLCVQLCIMDSTVCLR---LEGTNE 752
            :.|:|..:|:::||.|.:|...|.||.:|...:|   ||.........||  |.||   |:.|
Human   932 IVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMD--VALRMYPLKIT-- 992

  Fly   753 LHFGHFLLTNCPFMILLVFIETTRRYFIRLFPDSWLELATMY 794
                 :.|...|:.||:...:..|:..||..||.|:|..|.|
Human   993 -----WWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	262/820 (32%)
ATP1A4	NP_653300.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		P-type_ATPase_Na-K_like	70..1026	CDD:319794	261/817 (32%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	90..92
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	223..242