DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and ATP1A4

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_653300.2	Gene:	ATP1A4 / 480	HGNCID:	14073	Length:	1029	Species:	Homo sapiens

Alignment Length:	822	Identity:	263/822 - (31%)
Similarity:	421/822 - (51%)	Gaps:	81/822 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFKERSRSRSQKHQ----KQISYYMLLVAIVC 73
            |:....|:.:.|....:.:|.|.:|.:|.:..|      .|.....|    .:|.:::.|:.:|.
Human   249 NICFFSTNCVEGTARGIVIATGDSTVMGRIASL------TSGLAVGQTPIAAEIEHFIHLITVVA 307

  Fly    74 ------FILLFLTTG--------FEHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQ 124
                  |..|.|..|        |..|.||..|...||..:|..         |..|.|.|.||.
Human   308 VFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVC---------LTLTAKRMARKN 363

  Fly   125 CHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLD------VSAQSPRFIE 183
            |.|:||.|..|||.::.|.||..||:|:.||.|:.::.||.:...|..:      .:..|..:..
Human   364 CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFTKSSDTWFM 428

  Fly   184 LIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSE 248
            |.|.:.|||.|........:|..::...|:..:.|||||......|:..:|..:.|||...:||.
Human   429 LARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPFNST 493

  Fly   249 DKVQVTVHRTRD-ADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQEIILSLADGLLEA 312
            :|.|:::|...| :..|   ||:|||..|.::..||||.:..:|..::::::|...:....|...
Human   494 NKYQMSIHLREDSSQTH---VLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGL 555

  Fly   313 GRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKA 377
            |..|..|.:..|..  .|.:....||          |.:.....:|.|:|:|:..:|||:.:|.|
Human   556 GERVLGFCFLNLPS--SFSKGFPFNT----------DEINFPMDNLCFVGLISMIDPPRAAVPDA 608

  Fly   378 VDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEVVDMSQ------Y 436
            |.:||:||||:|:||...|..|||:|..|||:...::|.:.|..:...|.:: ||.|.      :
Human   609 VSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISK-VDASAAKAIVVH 672

  Fly   437 ADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVG 501
            ..|....|.:.::|::.|..::|.|.||..|...|.:.|:||||||:|.|..::|:||::.:.:|
Human   673 GAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIG 737

  Fly   502 VAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVYLFFFL 564
            :|.  .||.|..:| ||:||||.:||::|:.|.:.||:|:||||::.|.|.:||..|..:|.|.:
Human   738 IAMGISGSDVSKQA-ADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFII 801

  Fly   565 LGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VYDDFLLNSRLFFVSHILVGTI 628
            |||||.:..:..|.:....::|||::|.||..|.::|.::|: ...|.|:|.||..:::..:|.|
Human   802 LGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMI 866

  Fly   629 EAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLECQVSSLCLMS 693
            :|.|.|.||||.:|:.||.|..|:.:.:.|.|..|:|:.||:||:|:.|.|:.:|....:...::
Human   867 QALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVT 931

  Fly   694 LAVMQCTNLVLTKTGRANLLAHGFRNWLLSLAVL---LLICLCVQLCIMDSTVCLR---LEGTNE 752
            :.|:|..:|:::||.|.:|...|.||.:|...:|   ||.........||  |.||   |:.|
Human   932 IVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMD--VALRMYPLKIT-- 992

  Fly   753 LHFGHFLLTNCPFMILLVFIETTRRYFIRLFPDSWLELATMY 794
                 :.|...|:.||:...:..|:..||..||.|:|..|.|
Human   993 -----WWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	35/136 (26%)
		Cation_ATPase	190..284	CDD:289987	30/94 (32%)
		Cation_ATPase_C	582..777	CDD:295563	65/201 (32%)
ATP1A4	NP_653300.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		ATPase-IIC_X-K	35..1029	CDD:273445	262/820 (32%)
		Cation_ATPase_N	49..122	CDD:214842
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	90..92
		E1-E2_ATPase	154..373	CDD:278548	36/138 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..242
		Cation_ATPase	435..527	CDD:289987	30/94 (32%)
		COG4087	609..758	CDD:226572	56/150 (37%)
		Cation_ATPase_C	805..1014	CDD:279079	69/217 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850