DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and ATP1A3

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_001243143.1	Gene:	ATP1A3 / 478	HGNCID:	801	Length:	1026	Species:	Homo sapiens

Alignment Length:	834	Identity:	259/834 - (31%)
Similarity:	426/834 - (51%)	Gaps:	103/834 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFKERSRSRSQKHQK----QISYYMLL---VA 70
            |:....|:.:.|....|.:|.|..|.:|.:..|.      |..:..:.    :|.:::.|   ||
Human   244 NITFFSTNCVEGTARGVVVATGDRTVMGRIATLA------SGLEVGKTPIAIEIEHFIQLITGVA 302

  Fly    71 I---VCFILLFLTTG--------FEHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQ 124
            :   |.|.:|.|..|        |..|.||..|...||..:|..         |..|.|.|.||.
Human   303 VFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVC---------LTLTAKRMARKN 358

  Fly   125 CHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLD------VSAQSPRFIE 183
            |.|:||.|..|||.::.|.||..||:|:.||.|:.::.|..:...|..:      ....|..::.
Human   359 CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVA 423

  Fly   184 LIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSE 248
            |...:.|||.||...|...:|.:::|:.|:..:.||||...:...|:.|:|..::|||...:||.
Human   424 LSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNST 488

  Fly   249 DKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQEIILSLADGLLEAG 313
            :|.|:::|.|.|.:.: :.:|:|||..|.::.||||..::.:|.||||:::|...:....|...|
Human   489 NKYQLSIHETEDPNDN-RYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLG 552

  Fly   314 RHVRAFAYKELSDELEFRRFS----QVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTI 374
            ..|..|.:..|.:|...:.|:    .||               ..|.:|.|:|:::..:|||:.:
Human   553 ERVLGFCHYYLPEEQFPKGFAFDCDDVN---------------FTTDNLCFVGLMSMIDPPRAAV 602

  Fly   375 PKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEV--------- 430
            |.||.:||:||||:|:||...|..|||:|..|||:...::|.:.:..:...|.::|
Human   603 PDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACV 667

  Fly   431 ---VDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDT 492
               .|:..:..|:       |::::.|..::|.|.||..|...|.:.|:|.||:|:|.|..::|:
Human   668 IHGTDLKDFTSEQ-------IDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDS 725

  Fly   493 PAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICN 555
            ||::.:.:|||.  .||.|..:| ||:||||.:||::|:.|.:.||:|:||||::||.|.:||..
Human   726 PALKKADIGVAMGIAGSDVSKQA-ADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPE 789

  Fly   556 ILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VYDDFLLNSRLFF 619
            |..:|.|.:..|||.:..:..|.:....::|||::|.||..|.::|.:.|: ...|.|:|.||..
Human   790 ITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLIS 854

  Fly   620 VSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLEC 684
            :::..:|.|:|...|.:|||.:|:.||||..||.:.:.|.|..::|:.||:||:|:.|.|:.:|.
Human   855 MAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEF 919

  Fly   685 QVSSLCLMSLAVMQCTNLVLTKTGRANLLAHGFRNWLL--------SLAVLLLICLCVQLCIMDS 741
            ...:...:|:.|:|..:|::.||.|.::...|.:|.:|        :||..|..|..     ||
Human   920 TCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPG-----MD- 978

  Fly   742 TVCLRLEGTN-ELHFGHFLLTNCPFMILLVFIETTRRYFIRLFPDSWLELATMY 794
             |.||:.... ...|..|     |:..|:...:..|:..:|..|..|:|..|.|
Human   979 -VALRMYPLKPSWWFCAF-----PYSFLIFVYDEIRKLILRRNPGGWVEKETYY 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	37/136 (27%)
		Cation_ATPase	190..284	CDD:289987	33/93 (35%)
		Cation_ATPase_C	582..777	CDD:295563	62/204 (30%)
ATP1A3	NP_001243143.1	ATPase-IIC_X-K	30..1026	CDD:273445	258/832 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850