DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and ATP1A2

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_000693.1	Gene:	ATP1A2 / 477	HGNCID:	800	Length:	1020	Species:	Homo sapiens

Alignment Length:	844	Identity:	256/844 - (30%)
Similarity:	420/844 - (49%)	Gaps:	124/844 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTDLCF-KERSRSRSQKHQKQISYYMLL---VAI-- 71
            |:....|:.:.|....:.:|.|..|.:|.:..|.. .|..|:   ....:|.:::.|   ||:
Human   239 NICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRT---PIAMEIEHFIQLITGVAVFL 300

  Fly    72 -VCFILLFLTTGFEH--------GHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHV 127
             |.|.:|.|..|:..        |.||..|...||..:|..         |..|.|.|.||.|.|
Human   301 GVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVC---------LTLTAKRMARKNCLV 356

  Fly   128 RNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLD------VSAQSPRFIELIR 186
            :||.|..|||.::.|.||..||:|:.||.|:.::.|..:...|..:      ...:||.:..|.|
Human   357 KNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALSR 421

  Fly   187 ASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSEDKV 251
            .:.|||.||...|...:...::|..|:..:.||||...:...|:..:|..:.|||...:||.:|.
Human   422 IAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPFNSTNKY 486

  Fly   252 QVTVHRTRDA-DGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQ--------------EI 301
            |:::|...|: ..|   ||:|||..|.::.||||..::.:|:|||:::|              |.
Human   487 QLSIHEREDSPQSH---VLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYMELGGLGER 548

  Fly   302 ILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIAT 366
            :|......|.:|:..|.|.:.  :|||.|                       .|..|.|:|:::.
Human   549 VLGFCQLNLPSGKFPRGFKFD--TDELNF-----------------------PTEKLCFVGLMSM 588

  Fly   367 YNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEV- 430
            .:|||:.:|.||.:||:||||:|:||...|..|||:|..|||:...::|.:.:..:...|.::|
Human   589 IDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPMSQVN 653

  Fly   431 -----------VDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSV 484
                       .|:.....|:       :::::.|..::|.|.||..|...|.:.|:|.||:|:|
Human   654 PREAKACVVHGSDLKDMTSEQ-------LDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAV 711

  Fly   485 IGGTLHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAY 547
            .|..::|:||::.:.:|:|.  .||.|..:| ||:||||.:||::|:.|.:.||:|:||||::||
Human   712 TGDGVNDSPALKKADIGIAMGISGSDVSKQA-ADMILLDDNFASIVTGVEEGRLIFDNLKKSIAY 775

  Fly   548 CLATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VYDDF 611
            .|.:||..|..:|.|.:..|||.:..:..|.:....::|||::|.||..|.::|.:.|: ...|.
Human   776 TLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDK 840

  Fly   612 LLNSRLFFVSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSS 676
            |:|.||..:::..:|.|:|...|.||||.:|:.||||..|:.:.:.|.|..::|:.||:||||:.
Human   841 LVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYGQEWTY 905

  Fly   677 EARRQLECQVSSLCLMSLAVMQCTNLVLTKTGRANLLAHGFRNWLL--------SLAVLLLICLC 733
            |.|:.:|....:....|:.|:|..:|::.||.|.::...|.:|.:|        :||..|..|
Human   906 EQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSYC-- 968

  Fly   734 VQLCIMDSTVCLR---LEGTNELHFGHFLLTNCPFMILLVFIETTRRYFIRLFPDSWLELATMY 794
                 ....|.||   |:.|       :.....|:.:|:...:..|:..:|.:|..|:|..|.|
Human   969 -----PGMGVALRMYPLKVT-------WWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	36/133 (27%)
		Cation_ATPase	190..284	CDD:289987	32/94 (34%)
		Cation_ATPase_C	582..777	CDD:295563	61/206 (30%)
ATP1A2	NP_000693.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		ATPase-IIC_X-K	30..1020	CDD:273445	255/842 (30%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..231
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850