DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and PMCA

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster

Alignment Length:	903	Identity:	201/903 - (22%)
Similarity:	350/903 - (38%)	Gaps:	234/903 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MGLACTHAISGIGFAVALACGRNTEVGSMTDL--------------CFKERSRSRSQK------- 57
            |.|:.||.:.|.|..|..|.|.|::.|.:..|              ..||..|:..||
  Fly   235 MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGEND 299

  Fly    58 -------------------------------------------HQK--------------QISYY 65
                                                       |:|              ||.|.
  Fly   300 GRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYA 364

  Fly    66 MLLVAIVCFILLFLTTGFEHGHI-------VYEVNL--SLLIGLT------PVYLPFILYWGLRR 115
            ...:|::..|:|.:....:...|       .|..||  .|:||:|      |..||..:...|..
  Fly   365 GSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAY 429

  Fly   116 TRKEMGRKQCHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLDVSAQSPR 180
            :.|:|.:....||:|.|..|:|.:|.|.||..||:|..||.|.:.::...|..|  |...:..|:
  Fly   430 SVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKV--LPTLSDIPQ 492

  Fly   181 FI-ELIRASVLCNDAVIC-------PGNIGVPKMQKDMYGNILDIALLKF--GLMILPSIDLLRH 235
            .: .||...:..|.|...       ||::.:      ..||..:.|||.|  ||.:  ....:|.
  Fly   493 HVGNLITMGISVNSAYTSNIMAGHNPGDLPI------QVGNKTECALLGFVQGLGV--KYQSIRD 549

  Fly   236 D--HEKVANKH-YNSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRD---EELPL 294
            :  .:|....: :||..|...|| ..|...|:.   |..||..|:::::|:.....:   |:...
  Fly   550 EITEDKFTRVYTFNSVRKSMGTV-IPRPNGGYR---LYTKGASEIIMKKCAFIYGHEGTLEKFTR 610

  Fly   295 DEQ---LQEIILSLA-DGLLEAGRHVRAFAYKELSDELEFRRF----SQVNTGLEGGEYKYRDYL 351
            |.|   ::|:|..:| |||            :.:|  :.:|.|    :.:|.....||..:.|..
  Fly   611 DMQERLIREVIEPMACDGL------------RTIS--VAYRDFVPGKAAINEVHIDGEPNWDDEE 661

  Fly   352 AVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTF 416
            .:.| :|..|.::...:|.|..:|.|:.:|:.|||.:.:||......|:::|...||| .|:|.|
  Fly   662 NIMT-NLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGIL-RPNDDF 724

  Fly   417 QAVNLKRMPPTAEVVDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQ---LHWIADA-CRR 477
            ..:..|         :.::...:.....::|:...:..:..::..::.||:   :..|.|: ...
  Fly   725 LILEGK---------EFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSE 780

  Fly   478 LGAVVSVIGGTLHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFEN 540
            ...||:|.|...:|.||::.:.||.|.  .|:.|..||| |:||.|.:|:::|..|...|.::::
  Fly   781 NREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS-DIILTDDNFSSIVKAVMWGRNVYDS 844

  Fly   541 LKKALAYCLATNICNILVYLFFFLLGI---PLYIHIMDELILAFLVNLV----PALTLIYEPPEE 598
            :.|.|.:.|..|:..::| .|.....:   ||      :.:....|||:    .:|.|..|.|..
  Fly   845 IAKFLQFQLTVNVVAVIV-AFIGACAVQDSPL------KAVQMLWVNLIMDTLASLALATEFPTP 902

  Fly   599 NLMLQMPKVYDDFLLNSRLFFVSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDML 663
            :|:|:.|       .......:|..::..|...|::....:|              .:.:..|::
  Fly   903 DLLLRKP-------YGRTKPLISRTMMKNILGQALYQLIIIF--------------GLLFVGDVI 946

  Fly   664 DDITDSFGQEWSSEARRQLECQVSSLCLMSLAVMQCTNLVLTKTGRANLLAHGFRN--------- 719
            .||....|||.::...:......::..:|:|     .|.:..:.      .||.||
  Fly   947 LDIESGRGQELNAGPTQHFTIIFNTFVMMTL-----FNEINARK------IHGQRNVIEGLLTNP 1000

  Fly   720 -----WLLSLAVLLLICLCVQLCIMDSTVCLRLE--------GTNELHFGHFLLTNCP 764
                 |:.::...:||....::..  ||..|.|:        |...|.:|. |:|:.|
  Fly  1001 IFYTIWIFTMISQVLIIQYGKMAF--STKALTLDQWLWCIFFGIGTLVWGQ-LITSVP 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	42/210 (20%)
		Cation_ATPase	190..284	CDD:289987	26/105 (25%)
		Cation_ATPase_C	582..777	CDD:295563	40/209 (19%)
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	201/903 (22%)
		Cation_ATPase_N	36..104	CDD:279080
		E1-E2_ATPase	172..448	CDD:278548	43/212 (20%)
		Cation_ATPase	505..598	CDD:289987	26/104 (25%)
		HAD_like	676..807	CDD:119389	33/140 (24%)
		Cation_ATPase_C	873..1051	CDD:279079	39/218 (18%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930