DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and atp2b3a

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	XP_005166875.1	Gene:	atp2b3a / 436745	ZFINID:	ZDB-GENE-040718-174	Length:	1299	Species:	Danio rerio

Alignment Length:	679	Identity:	166/679 - (24%)
Similarity:	301/679 - (44%)	Gaps:	145/679 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RNTEVGSMTDLCFKERSRSRSQKHQKQI---------------SYYMLLVAIVCFILLFLTTGFE 84
            ::.|.|.:.:   ||:.::...|.:|.:               ...|..:.::..:|.|:...|
Zfish   357 KSAEGGEVEE---KEKKKASVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILMLYFVIKTF- 417

  Fly    85 HGHIVYE--------------------VNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRN 129
               ||::                    :.:::|:...|..||..:...|..:.|:|.:....||:
Zfish   418 ---IVHKQPWLTECTPIYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRH 479

  Fly   130 LRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNL--DVSAQ---SPRFIELIRASV 189
            |.|..|:|.:|.|.||..||:|..||.|.:|::.      |.|  |:...   :||.:|||.:::
Zfish   480 LDACETMGNATAICSDKTGTLTTNRMTVVQIYIG------DQLFRDIPTPDQINPRTLELISSAI 538

  Fly   190 LCNDAV---ICPGNI--GVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANK------ 243
            ..|.|.   |.|.:.  |:||    ..||..:.|||  ||:    :| |:.|::.|..:
Zfish   539 AVNCAYTSKIMPADKEGGLPK----QVGNKTECALL--GLV----LD-LKQDYQAVREQIPEELL 592

  Fly   244 ----HYNSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEEL------PLDEQL 298
                .:||..|...||  .:..||..:  |..||..|:::::||....||.|.      ..||.:
Zfish   593 YKVYTFNSVRKSMSTV--IQMPDGSFR--LYSKGASEILLKKCSFILSRDGEARAFRARDKDEMV 653

  Fly   299 QEIILSLA-DGLLEAGRHVRAFAYKEL-SDEL-EFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRF 360
            :::|..:| |||     .....||:|| :|.| ::...:.:                  ..:|..
Zfish   654 KKVIEPMACDGL-----RTICIAYRELPADPLPDWDNETDI------------------VSNLTC 695

  Fly   361 LGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMP 425
            :.::...:|.|..:|.|:.:|:.|||.:.:||......|:|:|...||: .|.|.|..:..|
Zfish   696 ITVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARAIAAKCGII-HPGDDFLCMEGK--- 756

  Fly   426 PTAEVVDMS-QYADEKPQHQRRHIEQLILNQQDLVCAATSTDQ---LHWIADAC---RRLGAVVS 483
                  |.: :..:||.:.::..|:: |..:..::..::.||:   :..|.|:.   :|  .||:
Zfish   757 ------DFNRRIRNEKGEIEQERIDK-IWPKLRVLARSSPTDKHTLVKGIIDSTVVEQR--QVVA 812

  Fly   484 VIGGTLHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALA 546
            |.|...:|.||::.:.||.|.  .|:.|..||| |:||.|.:|:::|..|...|.:::::.|.|.
Zfish   813 VTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS-DIILTDDNFSSIVKAVMWGRNVYDSISKFLQ 876

  Fly   547 YCLATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPKVYDDF 611
            :.|..|:..::|......:.....:..:..|.:..:::...:|.|..|||.|.|:|:.|     :
Zfish   877 FQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTEALLLRKP-----Y 936

  Fly   612 LLNSRLFFVSHILVGTIEAAAVFMTYFVF 640
            ..|:.|  :|..::..|...||:....:|
Zfish   937 GRNNPL--ISRTMMKNILGHAVYQLVIIF 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	22/131 (17%)
		Cation_ATPase	190..284	CDD:289987	30/108 (28%)
		Cation_ATPase_C	582..777	CDD:295563	16/59 (27%)
atp2b3a	XP_005166875.1	ATPase-IIB_Ca	23..1082	CDD:273668	166/679 (24%)
		Cation_ATPase_N	57..116	CDD:279080
		E1-E2_ATPase	164..484	CDD:278548	23/133 (17%)
		Cation_ATPase	545..634	CDD:289987	29/103 (28%)
		HAD	627..825	CDD:289480	55/233 (24%)
		Cation_ATPase_C	899..1077	CDD:279079	17/72 (24%)
		ATP_Ca_trans_C	1122..1198	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930