DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and Atp2b3

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	XP_006528144.1	Gene:	Atp2b3 / 320707	MGIID:	1347353	Length:	1249	Species:	Mus musculus

Alignment Length:	741	Identity:	167/741 - (22%)
Similarity:	296/741 - (39%)	Gaps:	173/741 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MGLACTHAISGIGFAVALACGRNTEVGSMTDLC-------------------------------- 46
            |.|:.||.:.|.|..|..|.|.|::.|.:..|.
Mouse   260 MLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGKQQDGAMDSSQTRAKKQD 324

  Fly    47 -----------------FKERSRSRSQKHQKQIS-----------------YYMLLVAIVCFILL 77
                             .:||.:.::...:|:.|                 ..|..:.::..:|.
Mouse   325 GAVAMEMQPLKSAEGGEMEEREKKKANVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLY 389

  Fly    78 FLTTGF-EHGHI-------VYE--------VNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCH 126
            |:...| ..|.:       ||.        :.:::|:...|..||..:...|..:.|:|.:....
Mouse   390 FVIETFVVDGRVWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNL 454

  Fly   127 VRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLDV-SAQSPRFIELIRASVL 190
            ||:|.|..|:|.:|.|.||..||:|..||.|.:.:  :|......:.. ||.:|:.::|:..::.
Mouse   455 VRHLDACETMGNATAICSDKTGTLTTNRMTVVQSY--LGDTHYKEIPAPSALTPKILDLLVHAIS 517

  Fly   191 CNDA----VICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANK-------- 243
            .|.|    ::.|...|....|   .||..:.|||.|.|      ||.| |.:.|..:
Mouse   518 INSAYTTKILPPEKEGALPRQ---VGNKTECALLGFVL------DLKR-DFQPVREQIPEDQLYK 572

  Fly   244 --HYNSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEEL------PLDEQLQE 300
              .:||..|...||  .|..||..:  |..||..|:::::|:.....:.||      ..|:.:::
Mouse   573 VYTFNSVRKSMSTV--IRMPDGGFR--LFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVKK 633

  Fly   301 IILSLA-DGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMI 364
            ||..:| |||     .....||::.|             .::..::...:.:..|   |..:.::
Mouse   634 IIEPMACDGL-----RTICIAYRDFS-------------AIQEPDWDNENEVVGD---LTCIAVV 677

  Fly   365 ATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAE 429
            ...:|.|..:|:|:.:|:.|||.:.:||......|:|:|...||: .|.:.|..:..|..
Mouse   678 GIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGII-QPGEDFLCLEGKEF----- 736

  Fly   430 VVDMSQYADEKPQHQRRHIEQLILNQ---QDLVCAATSTDQLHW-----IADACRRLGAVVSVIG 486
                    :.:.::::..|||..|::   :..|.|.:|....|.     |.........||:|.|
Mouse   737 --------NRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTTGEQRQVVAVTG 793

  Fly   487 GTLHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCL 549
            ...:|.||::.:.||.|.  .|:.|..||| |:||.|.:|.::|..|...|.:::::.|.|.:.|
Mouse   794 DGTNDGPALKKADVGFAMGIAGTDVAKEAS-DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQL 857

  Fly   550 ATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPKVYDDFLLN 614
            ..|:..::|......:.....:..:..|.:..:::...:|.|..|||.|:|:|:.|...|..|
Mouse   858 TVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPL-- 920

  Fly   615 SRLFFVSHILVGTIEAAAVFMTYFVF 640
                 :|..::..|...||:....:|
Mouse   921 -----ISRTMMKNILGHAVYQLTIIF 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	33/199 (17%)
		Cation_ATPase	190..284	CDD:289987	30/107 (28%)
		Cation_ATPase_C	582..777	CDD:295563	16/59 (27%)
Atp2b3	XP_006528144.1	ATPase-IIB_Ca	19..1061	CDD:273668	167/741 (23%)
Atp2b3	XP_006528144.1	ATP_Ca_trans_C	1100..1175	CDD:372101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930