DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and anne

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_001096849.1	Gene:	anne / 317815	FlyBaseID:	FBgn0052000	Length:	1451	Species:	Drosophila melanogaster

Alignment Length:	1067	Identity:	184/1067 - (17%)
Similarity:	317/1067 - (29%)	Gaps:	447/1067 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LACG----RNTEVGSMTDLCFKERSRSRSQKHQ---------------KQISYYMLLVAIVCFIL 76
            |.||    :...:||...|.|...:.:.:.|.:               :|.||     ..:.|:.
  Fly   494 LFCGTKVIQTRYIGSKKVLAFVINTGNITAKGELIRSILYPPPVDYKFEQDSY-----KFIQFLA 553

  Fly    77 LFLTTGFEHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRNLRATCTLGLSTV 141
            :....||     :|.:...:|.|..||.:                          |..:|.|.|:
  Fly   554 IIACVGF-----IYTLVTKILRGTDPVKI--------------------------AVESLDLITI 587

  Fly   142 IVSD-LVGTMT------KRRMRVSEIFV------------------DMGLLSVDNLDVSAQSPR- 180
            :|.. |...||      ::|::.||||.                  ..|.|:.|.||:....|:
  Fly   588 VVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKS 652

  Fly   181 ----------------FIELIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALL--------- 220
                            |...:...|.|:...|..|.         |.|:.||:.:.
  Fly   653 STNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGR---------MMGDPLDLKMFESTGWELED 708

  Fly   221 --------KFGLMILPSIDLLRHDH------------EKVANKHYNSEDKVQVTV-----HRTRD 260
                    |:|: :.|:|  ||...            .|...|..:|.|.:..||     .:..|
  Fly   709 SNNIPDTEKYGI-LYPTI--LRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFD 770

  Fly   261 -----------ADGHLKLV----------LLMKGHCEVVIRRCSTFAIRDEELPLDEQLQEIILS 304
                       |...:.:|          :..||..|::.:.|...::.|.   ..:||.|
  Fly   771 HGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPEMLKKLCKPQSLPDN---YSQQLSE---- 828

  Fly   305 LADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNP 369
                ..:.|..:.|.|:|.||.::.:.:..:::          |:.:   ..::.|||.:...|.
  Fly   829 ----FAKKGYRIIAIAFKALSHKMNYTKVQRLS----------REEV---ENNMEFLGFVILENR 876

  Fly   370 PRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEV---- 430
            .:....|.::...||.|:.|::|......|.::|.|.||: :||.:...|:...:..:|.:
  Fly   877 LKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIV-SPSQSVITVHADPIGDSANIQTNT 940

  Fly   431 -------------------VDM------------------------------------------- 433
                               :|:
  Fly   941 GTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTAQVGKTIFHMESTNSL 1005

  Fly   434 -----SQYAD----------------------------EKPQHQRRHIEQL-------------- 451
                 |.||:                            ..|....|..|.:
  Fly  1006 VNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQECIFAMDGKTWQIVKDY 1070

  Fly   452 ------ILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVM 510
                  ||..:..:.|..|.||...:....:.|...|::.|...:|..|::.:|.|::      :
  Fly  1071 FPEEMEILLTRGSIYARMSPDQKQALVIELQNLDYCVAMCGDGANDCGALKVAHAGIS------L 1129

  Fly   511 CEASADLILLDTSFATLVSVV------GDSRLL--FENLKKALAYCLATNICNILVYLFFFLLGI 567
            .|..|.:....||....:|.|      |.:.|:  |...|...||.|...|..:::|.....|..
  Fly  1130 SETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLVQFISVMILYSIDSNLTD 1194

  Fly   568 PLYIHIMDELILAF-------------LVNLVPALTLIYEPPEENLMLQMPKVYDDFLLNSRLFF 619
            ..|:::...||..|             ||..||..:||...|..:|:|
  Fly  1195 KQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPLSSLISSTPLASLLL----------------- 1242

  Fly   620 VSHILVGTIEAAAVFMTYFVFMAD----KGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARR 680
              |:.|.|    |..:|.:|.:..    |.|.|              .|:  |..|
  Fly  1243 --HLTVVT----AFQVTCWVHLHQQPWFKAFEP--------------ADE--DHLG--------- 1276

  Fly   681 QLEC--QVSSLCLMSLAVMQCTNLVLTKTGRANLLAHGF-----------RNWLLSLAVLLLICL 732
               |  ..:..|:.|...:              :||..|           .||.|.||.::.:|:
  Fly  1277 ---CFENYTMFCISSFQYI--------------ILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCI 1324

  Fly   733 CVQLCIMDS---TVCLRLEGTNELHFGHFLLT-NCPFMILLVFIE-------------------- 773
            .|.|.:..|   ....:|.....:.|.:.:|. .....|..:|:|
  Fly  1325 IVYLVLYPSDWVASFFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVEYLVFKKYQVKREKNW 1389

  Fly   774 -TTRRYFIRLFPD-----SWLELATMY 794
             |:::.::||..|     :|..:..:|
  Fly  1390 VTSKQKYMRLEHDISNIKNWPPITEVY 1416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	19/119 (16%)
		Cation_ATPase	190..284	CDD:289987	26/148 (18%)
		Cation_ATPase_C	582..777	CDD:295563	43/236 (18%)
anne	NP_001096849.1	P5-ATPase	158..291	CDD:289194
		P-ATPase-V	173..1355	CDD:273738	174/1004 (17%)
		E1-E2_ATPase	381..621	CDD:278548	32/162 (20%)
		Cation_ATPase	<758..813	CDD:289987	8/54 (15%)
		HAD_like	<1087..1137	CDD:304363	12/55 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930