DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and Atp13a5

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	XP_038944228.1	Gene:	Atp13a5 / 303856	RGDID:	1306792	Length:	1237	Species:	Rattus norvegicus

Alignment Length:	949	Identity:	182/949 - (19%)
Similarity:	314/949 - (33%)	Gaps:	309/949 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WSSSNMG------LAC-THAI----SGIG--FAVALACGRNTEVGSMTDLCFKERSRSRSQKHQK 60
            |.|.::.      |.| |..|    ||.|  .||.|..|.||..|.:.          ||..:.:
  Rat   334 WKSHSLEDYRKHVLFCGTEVIQVKPSGQGPVRAVVLQTGYNTAKGDLV----------RSILYPR 388

  Fly    61 QISY--------YMLLVAIVCFILLFLTTGFEHGHIVYEV--------NLSLLIGLTPVYLPFIL 109
            .:::        :|:.:|.:..:..|...|.   ::.:||        .|.||....|..||..|
  Rat   389 PLNFKLYNDAFKFMVFLACIGVVGFFYALGV---YLYHEVPPRETVTMALILLTATVPPVLPAAL 450

  Fly   110 YWGLRRTRKEMGRKQCHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLDV 174
            ..|....:|.:.:|:....:.:.....|...::..|..||:|:                 |.||:
  Rat   451 TIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTE-----------------DGLDL 498

  Fly   175 ------------------SAQSPRFIELIRASVLCNDAVICPGNI-GVP---KMQKDMYGNILD- 216
                              |.::..:..|..|...|:..::..|.| |.|   ||.:....|:.|
  Rat   499 WGTVPTAGNCFQAVHSFASGEAVPWGPLCAAMASCHSLILLDGTIQGDPLDLKMFEGTGWNMEDG 563

  Fly   217 -IALLKF-----GLMILP----------SIDLLRHDHEKVANKHYNSEDKVQVTVHRTRDADGHL 265
             :|..|:     |.:|.|          ||.:||        :...|....:::|  .....|.|
  Rat   564 QVASCKYSTADSGTVIKPGPNASQSPVDSITILR--------QFPFSSGLQRMSV--IAQLAGDL 618

  Fly   266 KLVLLMKGHCEVVIRRCSTFAIRDEELP--LDEQLQEIILSLADGLLEAGRHVRAFAYKELSDEL 328
            :|.:.|||..|:|.|.||:     |.:|  ..::|:...:.        |..|.|.|:|.|..|
  Rat   619 RLHVYMKGAPEMVARFCSS-----ETVPKNFPQELRNYTVQ--------GFRVIALAHKTLKME- 669

  Fly   329 EFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQ 393
               :.|.|       |...|:.:..:   |.|||::...|..::.....:.....|.|:.::||.
  Rat   670 ---KVSDV-------ERLAREKVESE---LAFLGLLIMENRLKNETRPVLQELSEARIRTVMVTG 721

  Fly   394 RKPKMAKALAVDVGILPA-----------PSD------TFQAVNLKRMPPTAEVVDMSQYADEKP 441
            ...:.|..:|.:..::|.           |.|      |:|.|..:......:|...||.....|
  Rat   722 DNLQTAITVAKNSEMIPVGSQVIIVEANEPGDLVPASVTWQLVGTQEPGSEKKVSQGSQQCFRSP 786

  Fly   442 ---------------------------------------QHQRRHIEQLILNQQDLVCAATSTDQ 467
                                                   .|....:.|:::|  ..|.|..|..|
  Rat   787 CRNHAFRFQDTYIDIGNSSVPCGKGYHFAMSGKSYQVLFHHFYSMLPQILVN--GTVFARMSPGQ 849

  Fly   468 LHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVMCEASADLILLDTSFATLVSVV- 531
            ...:.:..::|...|.:.|...:|..|::.:|.|::      :.|..|.:....||....:..|
  Rat   850 KSSLVEEFQKLNYYVGMCGDGANDCGALKMAHAGIS------LSEQEASVASPFTSKVANIECVP 908

  Fly   532 -----GDSRLL--FENLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPAL 589
                 |.:.|:  |...|....|.:...|...|:|....|.|  .|.:::.::.:..:|:|..::
  Rat   909 HLIREGRAALVSSFGVFKYLTMYGIIQFIGTSLLYWQLQLFG--NYQYLLQDVAITLMVSLTMSI 971

  Fly   590 TLIY---EPPEENLMLQMPKVYDDFLLNSRLFFVSHILVGTIEAAAVFMTYFVFMADKGFLPRTL 651
            ...|   .|......|..|::.....:||  .|...:||.|            |::.|
  Rat   972 NHAYPKLAPYRPAGQLLSPQLLLSVFMNS--CFTCIVLVCT------------FLSVK------- 1015

  Fly   652 VALNIAWHDDMLDDITDSFGQEWSSEARRQLECQVSSLCLMSLAVMQCTNLVLTK--TGRANLLA 714
                               .|.|..|..:..||.:.:....|      ||:.|.:  ||.|.|:.
  Rat  1016 -------------------QQPWYCEVYKYSECFLVNQSNFS------TNMGLERNWTGNATLVP 1055

  Fly   715 HG----------------------------------FRNWLLSLAVLLLICLCVQLCIMD-STVC 744
            ..                                  :.|:|.||.:...:.|.|.:...| ..:.
  Rat  1056 ASVLSFEGTTLWPIVTFNCISAAFIFSKGKPFRKPIYTNYLFSLLLTSAVGLTVFILFSDFQDIY 1120

  Fly   745 LRLEGTNELHFGHFLLTNCPFMILLV---FIETTRRYFI 780
            .|:|         |:.|...:.|.::   |::....:|:
  Rat  1121 RRME---------FIPTTTSWRISILVAAFVQFCVAFFV 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	32/147 (22%)
		Cation_ATPase	190..284	CDD:289987	30/114 (26%)
		Cation_ATPase_C	582..777	CDD:295563	40/237 (17%)
Atp13a5	XP_038944228.1	P5-ATPase	23..142	CDD:403569
Atp13a5	XP_038944228.1	P-type_ATPase_cation	174..1020	CDD:319842	156/802 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334721
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930