DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and Atp13a4

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_001178587.2	Gene:	Atp13a4 / 288026	RGDID:	1306927	Length:	1193	Species:	Rattus norvegicus

Alignment Length:	900	Identity:	169/900 - (18%)
Similarity:	301/900 - (33%)	Gaps:	288/900 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SGIGFAVALACGRNTEVGSMTDLCFKERSRSRSQKHQKQISYYMLLVAIVCFILLFL---TTGFE 84
            ||...||.|..|.||..|.:.          ||..:.|.:::.:...|| .|:|..:   |.|..
  Rat   362 SGTVRAVVLQTGFNTAKGDLV----------RSILYPKPMNFKLYRDAI-RFLLCLVGTATIGMI 415

  Fly    85 HGHIVYEVN-----------LSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRNLRATCTLGL 138
            :...||.::           |.::....|..||..|..|:...::.:.:|.....:.:.....|.
  Rat   416 YTLCVYVLSGEPPEEVVRKALDVITIAVPPALPAALTTGIIYAQRRLKKKGIFCISPQRINVCGQ 480

  Fly   139 STVIVSDLVGTMTKRRMRVSEIFVDMGLLSVD-------NLDVSAQSPRFIELIRASVLCNDAVI 196
            ..::..|..||:|:..:.:      .|::..|       :...|.::..:..|..|...|:..::
  Rat   481 LNLVCFDKTGTLTRGGLDL------WGVVPCDQNGFQAVHSFASGEAVPWGPLCAAMATCHSLIL 539

  Fly   197 CPGNIGVPKMQKDMYGNILDI--------------------ALLKFGLMILPSIDLLRHDHEKVA 241
            ..|.|         .|:.||:                    .:|...:::.|...:.:...|.:|
  Rat   540 LDGTI---------QGDPLDLKMFEATQWEMTVSGDDFHNKEMLAHTMVVKPPDTVGQVPAEGLA 595

  Fly   242 NKHY----NSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRC------STFAIRDEELPLDE 296
            ..|.    ::..::.|.|..|  ..|.:   ..|||..|.|...|      :||
  Rat   596 ILHQFPFSSALQRMTVIVQET--GGGRM---AFMKGAPERVASFCQPDTVPTTF----------- 644

  Fly   297 QLQEIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFL 361
             :.|:.:....|.     .|.|.|||:|..:..       .|.|      .|:.:..|   |.||
  Rat   645 -ISELQVYTTQGF-----RVIALAYKKLETDCP-------TTTL------MREKVESD---LIFL 687

  Fly   362 GMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPS-----DTFQAVNL 421
            |::...|..:......::...:|.|:..::|....:.|..:|...|::....     :..:|.:.
  Rat   688 GLLILENRLKEETRPVLEELISARIRTAMITGDNLQTAITVARKSGMVSEGQKVILVEANEATDS 752

  Fly   422 KRMPPTAEVVDMSQYA------------DEKPQHQR-----------------RH----IEQLIL 453
            .....|.::|:..::.            :|.|::.|                 :|    :.::::
  Rat   753 SSASITWKLVEEKKHGLFGSQDTYINIREEVPENGREGNYHFALSGKSFQVISQHFSSLLPKILI 817

  Fly   454 NQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGV------AKYGSA---- 508
            |  ..:.|..|..|...:.:..::|...|.:.|...:|..|::.:||||      |...|.
  Rat   818 N--GTIFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGALKMAHVGVSLSEQEASVASPFTSK 880

  Fly   509 ---VMC------EASADLILLDTSFA--------TLVSVVGDSRLLFENLKKALAYCLATNICNI 556
               :.|      |..|.|:   |||.        :::..||          ..|.|....::.|
  Rat   881 TPNIECVPHLIKEGRAALV---TSFCMFKYMALYSMIQYVG----------VLLLYWKTNSLSN- 931

  Fly   557 LVYLFFF-------LLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPKVYDDFLLN 614
              |.|.|       |:|:.:.::..:..::.|.    ||..|| .||   |:|.:       :||
  Rat   932 --YQFLFQDLAITTLIGVTMNLNGANPKLVPFR----PAGRLI-SPP---LLLSV-------ILN 979

  Fly   615 SRLFFVSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEAR 679
            ..|....||:                    ||:   ||.                 .|.|.|
  Rat   980 ILLSLAMHIV--------------------GFI---LVQ-----------------KQPWYS--- 1001

  Fly   680 RQLECQVSSLCLM---SLAVMQCTNLVLTKTGRANLLAHGFRN---WLLSLAVLLLICLCVQLCI 738
                ....|:|.:   |::.:..:..|..|| |:|.....|.|   |.|.    .:.|:.|.|..
  Rat  1002 ----MDYHSVCPVRNESVSALSASPNVPEKT-RSNSTFASFENTTIWFLG----TINCIVVALVF 1057

  Fly   739 MDSTVCLRLEGTNELHFGHFLLT------NCPFMILLVFIETTRRYFIRLFPDSW 787
            .......:...||.:    |:|.      .|.|::.....|..||..:...|..|
  Rat  1058 SKGKPFRQPTYTNYI----FVLVLILQMGVCLFILFADIPELHRRLDLLCTPVLW 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	27/122 (22%)
		Cation_ATPase	190..284	CDD:289987	21/123 (17%)
		Cation_ATPase_C	582..777	CDD:295563	42/206 (20%)
Atp13a4	NP_001178587.2	P5-ATPase	17..142	CDD:403569
Atp13a4	NP_001178587.2	P-type_ATPase_cation	174..1000	CDD:319842	141/774 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930