DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and Atp1a4

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_038762.1	Gene:	Atp1a4 / 27222	MGIID:	1351335	Length:	1032	Species:	Mus musculus

Alignment Length:	822	Identity:	263/822 - (31%)
Similarity:	418/822 - (50%)	Gaps:	92/822 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 THAISGIGFAVALACGRNTEVGSMTDLCFKERSRSRSQKHQKQIS-----YYMLLVAI-----VC 73
            |:.:.|....:.:|.|..|.:|.:..|      .|..|..:..|:     :..|:.|:     |.
Mouse   257 TNCVEGTARGIVIATGDYTVMGRIASL------TSGLQMGKTPIATEIEHFIHLITAVAVFLGVS 315

  Fly    74 FILLFLTTG--------FEHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRNL 130
            |..|.:..|        |..|.||..|...||..:|..         |..|.|.|.||.|.|:||
Mouse   316 FFWLSIILGYTWLDAVIFLIGIIVANVPEGLLATVTVC---------LTLTAKRMARKNCLVKNL 371

  Fly   131 RATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLDVSA-------QSPRFIELIRAS 188
            .|..|||.::.|.||..||:|:.||.|:.::.|..:...|..:...       .|..:..|.|.:
Mouse   372 EAVETLGSTSTICSDKTGTLTQNRMTVAHLWFDKTVYEADTSEEQTTGKTFPKSSDTWFYLARIA 436

  Fly   189 VLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSEDKVQV 253
            .|||.|...|....||..::...|:..:.|||||.......:..:|..:.|||...:||.:|.|:
Mouse   437 GLCNRADFKPHQESVPIAKRATTGDASESALLKFIEQSYNPVSEMRQKNPKVAEIPFNSTNKYQM 501

  Fly   254 TVHRTRD-ADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQL----QEIILSLADGLLEAG 313
            ::|...| ::.|   ||||||..|.:...||:|.:..:|.|:||::    |...:.|. ||   |
Mouse   502 SIHLLEDNSEAH---VLLMKGAPERIFDFCSSFLLNGQEYPMDEEMKMDFQNAYIELG-GL---G 559

  Fly   314 RHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAV 378
            ..|..|.:..|..  .|.:..|.||          |.|.....:|.|.|:|:..:|||:.:|.||
Mouse   560 ERVLGFCFLNLPS--NFSKGFQFNT----------DELNFPMENLCFAGLISMIDPPRTAVPDAV 612

  Fly   379 DRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEVVDMS-----QYAD 438
            .:||:||||:|:||...|..|||:|..|||:...:||.:.:..:...|.::|.:.|     .:..
Mouse   613 SKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNDTAEDIAARLNIPISQVNNKSVKAIVVHGS 677

  Fly   439 EKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVA 503
            |....:.:.::.::.:.:::|.|.||..|...|.:.|:||||:|:|.|..::|:||::.:.:|:|
Mouse   678 ELKDMESQQLDDILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGIA 742

  Fly   504 K--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVYLFFFLLG 566
            .  .||.|..:| ||:||||.:||::|:.|.:.||:|:||||::||.|.:||..|..:|.|.:|.
Mouse   743 MGITGSDVSKQA-ADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIILS 806

  Fly   567 IPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VYDDFLLNSRLFFVSHILVGTIEA 630
            |||.:..:..|.:....::|||::|.||.||.::|.::|: ...|.|:|:||..:::..:|.|:|
Mouse   807 IPLPLGTITILCIDLGTDMVPAISLAYESPESDIMKRLPRNPKTDNLVNNRLIGMAYGQIGMIQA 871

  Fly   631 AAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLECQVSSLCLMSLA 695
            .|.|.||||.:|:.||.|..|:.:.:.|.|..|:|:.||:||:|:.|.|:.:|....:...:|:.
Mouse   872 LAGFFTYFVILAENGFKPLDLLGIRLYWDDTQLNDLEDSYGQQWTYEQRKVVEFTCQTAFFISIV 936

  Fly   696 VMQCTNLVLTKTGRANLLAHGFRNWLLSLAVLLLICLCVQLCI---MDSTVCLRLEGTNELHFGH 757
            ::|..:|::.||.|.:|...|.:|.:|...:|....|...|..   ||  |.||:         :
Mouse   937 IVQWADLIICKTRRNSLFKQGMKNKILIFGLLEETVLAAFLSYVPGMD--VSLRM---------Y 990

  Fly   758 FLLTN---C--PFMILLVFIETTRRYFIRLFPDSWLELATMY 794
            .|..|   |  |:.:|:...:..|:..||..|..|||..|.|
Mouse   991 PLKINWWFCALPYSVLIFVYDEIRKLIIRRRPGGWLEKETYY 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	34/130 (26%)
		Cation_ATPase	190..284	CDD:289987	32/94 (34%)
		Cation_ATPase_C	582..777	CDD:295563	64/203 (32%)
Atp1a4	NP_038762.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		ATPase-IIC_X-K	36..1032	CDD:273445	262/820 (32%)
		Cation_ATPase_N	50..123	CDD:214842
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	91..93
		E1-E2_ATPase	144..375	CDD:278548	35/132 (27%)
		Cation_ATPase	438..530	CDD:289987	32/94 (34%)
		COG4087	<696..761	CDD:226572	27/65 (42%)
		Cation_ATPase_C	808..1017	CDD:279079	68/219 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831004
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840