DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and Atp4a

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_036641.1	Gene:	Atp4a / 24216	RGDID:	2177	Length:	1034	Species:	Rattus norvegicus

Alignment Length:	836	Identity:	246/836 - (29%)
Similarity:	402/836 - (48%)	Gaps:	94/836 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SKWSSSNMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFKERSRSRSQKHQK-----QISYYM 66
            |...:.|:....|..:.|....:.::.|..|.:|.:..|       :...:::|     :|.:::
  Rat   245 SPLETRNIAFFSTMCLEGTAQGLVVSTGDRTIIGRIASL-------ASGVENEKTPIAIEIEHFV 302

  Fly    67 LLVA--IVCFILLFLTTGFEHGHIVYEVN---LSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCH 126
            .::|  .:.|...|.......|:......   :::::...|..|...:...|..|.|.:..|.|.
  Rat   303 DIIAGLAILFGATFFVVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCV 367

  Fly   127 VRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNL-DVSAQ-----SPRFIELI 185
            |:||.|..|||.::||.||..||:|:.||.||.::.|..:.:.|.. |.|.|     |..:..|.
  Rat   368 VKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALC 432

  Fly   186 RASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSEDK 250
            |...|||.|....|...||..::.:.|:..:.|||||..:.|.:....|....||....:||.:|
  Rat   433 RVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNK 497

  Fly   251 VQVTVHRTRDA--DGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQEII----LSLADGL 309
            .|:::|...|.  ..||   |:|||..|.|:.|||:..|:.:|||||||.:|..    |||. ||
  Rat   498 FQLSIHTLEDPRDPRHL---LVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLG-GL 558

  Fly   310 LEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTY----------SLRFLGMI 364
               |..|..|....|::                     :||....|:          .|.|.|::
  Rat   559 ---GERVLGFCQLYLNE---------------------KDYPPGYTFDVEAMNFPSSGLCFAGLV 599

  Fly   365 ATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLK-RMP--- 425
            :..:|||:|:|.||.:||.|||::|:||...|..|||:|..|||:...|:|.:.:..: |||
  Rat   600 SMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRMPVDQ 664

  Fly   426 -----PTAEVVDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVI 485
                 ..|.|::..|..|..|.    .:.:.:....::|.|.||..|...|.::|:||||:|:|.
  Rat   665 VNKKDARACVINGMQLKDMDPS----ELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVT 725

  Fly   486 GGTLHDTPAMRSSHVGVAK-YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCL 549
            |..::|:||::.:.:|||. ...:...:.:||:||||.:||::|:.|...||:|:||||::||.|
  Rat   726 GDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTL 790

  Fly   550 ATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VYDDFLL 613
            ..||..:..||.:..:.:||.:..:..|.:....::.|:::|.||..|.::|...|: ...|.|:
  Rat   791 TKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPRRDRLV 855

  Fly   614 NSRLFFVSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEA 678
            |..|...|:..:|.|::.|.|..||..||.:|:.|...|.|...|.|..|.|:.||:||||:...
  Rat   856 NEPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGLRPQWEDHHLQDLQDSYGQEWTFGQ 920

  Fly   679 RRQLECQVSSLCLMSLAVMQCTNLVLTKTGRANLLAHG-FRNWLLSLAVLLLICLCVQLCIMDST 742
            |...:....::..:|:.:.|..::::.||.|.:....| |||.:|.:|::..:|:...||.....
  Rat   921 RLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGM 985

  Fly   743 VCLRLEGTNELHF----GHFLLTNCPFMILLVFIETTRRYFIRLFPDSWLELATMY 794
                   .|..:|    ..:.|...||.:|:...:..|:..:|..|.||.:....|
  Rat   986 -------PNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	23/128 (18%)
		Cation_ATPase	190..284	CDD:289987	33/95 (35%)
		Cation_ATPase_C	582..777	CDD:295563	55/200 (28%)
Atp4a	NP_036641.1	H-K_ATPase_N	2..>27	CDD:286172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..40
		ATPase-IIC_X-K	42..1034	CDD:273445	245/834 (29%)
		Cation_ATPase_N	50..124	CDD:214842
		E1-E2_ATPase	145..375	CDD:278548	25/136 (18%)
		Cation_ATPase	437..531	CDD:289987	34/96 (35%)
		COG4087	<687..>742	CDD:226572	17/54 (31%)
		Cation_ATPase_C	809..1018	CDD:279079	59/215 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334733
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850