DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and Atp2b2

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_036640.1	Gene:	Atp2b2 / 24215	RGDID:	2176	Length:	1198	Species:	Rattus norvegicus

Alignment Length:	890	Identity:	196/890 - (22%)
Similarity:	347/890 - (38%)	Gaps:	220/890 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MGLACTHAISGIGFAVALACGRNTEVGSMTDLC----FKERSRSRSQK----------------- 57
            |.|:.||.:.|.|..|..|.|.|::.|.:..|.    .:|..:.:..|
  Rat   257 MLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGAAAMEMQPLKSAE 321

  Fly    58 ------------HQKQIS-----------------YYMLLVAIVCFILLFLTTGFEHG------- 86
                        |:|:.|                 ..|..:.::..:|.|....|...
  Rat   322 GGDADDKKKANMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLTE 386

  Fly    87 ----HIVYEVNLSLLIGLT------PVYLPFILYWGLRRTRKEMGRKQCHVRNLRATCTLGLSTV 141
                ::.|.|.. .:||:|      |..||..:...|..:.|:|.:....||:|.|..|:|.:|.
  Rat   387 CTPVYVQYFVKF-FIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATA 450

  Fly   142 IVSDLVGTMTKRRMRVSEIFV-DMGLLSVDNLDVSAQSPRFIELIRASVLCNDA----VICPGNI 201
            |.||..||:|..||.|.:.:| |:....:.  |.|:.:.:.:||:..::..|.|    ::.|...
  Rat   451 ICSDKTGTLTTNRMTVVQAYVGDVHYKEIP--DPSSINAKTLELLVNAIAINSAYTTKILPPEKE 513

  Fly   202 GVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANK----------HYNSEDKVQVTVH 256
            |....|   .||..:..||.|.|.       ||.|:|.|.::          .:||..|...||.
  Rat   514 GALPRQ---VGNKTECGLLGFVLD-------LRQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVI 568

  Fly   257 RTRDADGHLKLVLLMKGHCEVVIRRC----------STFAIRDEELPLDEQLQEIILSLA-DGLL 310
            :..|.    ...:..||..|:|:::|          ..|..||.    ||.::::|..:| |||
  Rat   569 KMPDE----SFRMYSKGASEIVLKKCCKILSGAGEPRVFRPRDR----DEMVKKVIEPMACDGL- 624

  Fly   311 EAGRHVRAFAYKEL--SDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRST 373
                .....||::.  |.|.::...:.:                  ...|..:.::...:|.|..
  Rat   625 ----RTICVAYRDFPSSPEPDWDNENDI------------------LNELTCICVVGIEDPVRPE 667

  Fly   374 IPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEVVDMSQYAD 438
            :|:|:.:|:.|||.:.:||......|:|:|:..||: .|.:.|..:..|..        ..:..:
  Rat   668 VPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGII-HPGEDFLCLEGKEF--------NRRIRN 723

  Fly   439 EKPQHQRRHIEQLILNQQDLVCAATSTDQ---LHWIADACR-RLGAVVSVIGGTLHDTPAMRSSH 499
            ||.:.::..|:: |..:..::..::.||:   :..|.|:.. ....||:|.|...:|.||::.:.
  Rat   724 EKGEIEQERIDK-IWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKAD 787

  Fly   500 VGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVYLFF 562
            ||.|.  .|:.|..||| |:||.|.:|:::|..|...|.:::::.|.|.:.|..|:..::|....
  Rat   788 VGFAMGIAGTDVAKEAS-DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 851

  Fly   563 FLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILVGT 627
            ..:.....:..:..|.:..:::...:|.|..|||.|.|:|:.|...:..|::..:  :.:||...
  Rat   852 ACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTM--MKNILGHA 914

  Fly   628 I-EAAAVFMTYFV----FMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLECQVS 687
            : :...:|...||    |..|.|        .|...|....:..|..|.
  Rat   915 VYQLTLIFTLLFVGEKMFQIDSG--------RNAPLHSPPSEHYTIIFN---------------- 955

  Fly   688 SLCLMSLAVMQCTNLVLTKT--GRANLLAHGFRNWLLSLAVLLLICLCVQLCIMD------STVC 744
                 :..:||..|.:..:.  |..|:....|||.:  ...::|....:|:.|:.      |...
  Rat   956 -----TFVMMQLFNEINARKIHGERNVFDGIFRNPI--FCTIVLGTFAIQIVIVQFGGKPFSCSP 1013

  Fly   745 LRLE--------GTNELHFGHFLLTNCPFMILLVFIETTRRYFIR 781
            |:|:        |..||.:|..:.|          |.|:|..|::
  Rat  1014 LQLDQWMWCIFIGLGELVWGQVIAT----------IPTSRLKFLK 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	35/184 (19%)
		Cation_ATPase	190..284	CDD:289987	27/117 (23%)
		Cation_ATPase_C	582..777	CDD:295563	43/215 (20%)
Atp2b2	NP_036640.1	ATPase-IIB_Ca	12..1042	CDD:273668	193/882 (22%)
		Cation_ATPase_N	51..113	CDD:279080
		E1-E2_ATPase	161..443	CDD:278548	36/186 (19%)
		Cation_ATPase	504..593	CDD:289987	25/102 (25%)
		HAD	<645..784	CDD:289480	34/166 (20%)
		Cation_ATPase_C	858..1036	CDD:279079	41/210 (20%)
		ATP_Ca_trans_C	1081..1128	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334709
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930