DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and Atp1a2

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_036637.1	Gene:	Atp1a2 / 24212	RGDID:	2168	Length:	1020	Species:	Rattus norvegicus

Alignment Length:	847	Identity:	255/847 - (30%)
Similarity:	419/847 - (49%)	Gaps:	130/847 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFKERSRSRSQKHQ----KQISYYMLL---VA 70
            |:....|:.:.|....:.:|.|..|.:|.:..|.      |..:..|    .:|.:::.|   ||
  Rat   239 NICFFSTNCVEGTARGIVIATGDRTVMGRIATLA------SGLEVGQTPIAMEIEHFIQLITGVA 297

  Fly    71 I---VCFILLFLTTGFEH--------GHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQ 124
            :   |.|.:|.|..|:..        |.||..|...||..:|..         |..|.|.|.||.
  Rat   298 VFLGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVC---------LTLTAKRMARKN 353

  Fly   125 CHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLD------VSAQSPRFIE 183
            |.|:||.|..|||.::.|.||..||:|:.||.|:.::.|..:...|..:      ...:||.:..
  Rat   354 CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTA 418

  Fly   184 LIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSE 248
            |.|.:.|||.||...|...:...::|..|:..:.||||...:...|:..:|..:.|||...:||.
  Rat   419 LSRIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPFNST 483

  Fly   249 DKVQVTVHRTRDA-DGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQ------------- 299
            :|.|:::|...|: ..|   ||:|||..|.::.||||..::.:|:|||:::|
  Rat   484 NKYQLSIHEREDSPQSH---VLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYMELGGL 545

  Fly   300 -EIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGM 363
             |.:|......|.:|:..|.|.:.  :|||.|                       .|..|.|:|:
  Rat   546 GERVLGFCQLNLPSGKFPRGFKFD--TDELNF-----------------------PTEKLCFVGL 585

  Fly   364 IATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTA 428
            ::..:|||:.:|.||.:||:||||:|:||...|..|||:|..|||:...::|.:.:..:...|.:
  Rat   586 MSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVS 650

  Fly   429 EV------------VDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAV 481
            :|            .|:.....|:       :::::.:..::|.|.||..|...|.:.|:|.||:
  Rat   651 QVNPREAKACVVHGSDLKDMTSEQ-------LDEILRDHTEIVFARTSPQQKLIIVEGCQRQGAI 708

  Fly   482 VSVIGGTLHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKA 544
            |:|.|..::|:||::.:.:|:|.  .||.|..:| ||:||||.:||::|:.|.:.||:|:||||:
  Rat   709 VAVTGDGVNDSPALKKADIGIAMGISGSDVSKQA-ADMILLDDNFASIVTGVEEGRLIFDNLKKS 772

  Fly   545 LAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VY 608
            :||.|.:||..|..:|.|.:..|||.:..:..|.:....::|||::|.||..|.::|.:.|: ..
  Rat   773 IAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQ 837

  Fly   609 DDFLLNSRLFFVSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQE 673
            .|.|:|.||..:::..:|.|:|...|.||||.:|:.||||..|:.:.:.|.|...:|:.||:|||
  Rat   838 TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTTNDLEDSYGQE 902

  Fly   674 WSSEARRQLECQVSSLCLMSLAVMQCTNLVLTKTGRANLLAHGFRNWLL--------SLAVLLLI 730
            |:.|.|:.:|....:....|:.|:|..:|::.||.|.::...|.:|.:|        :||..|..
  Rat   903 WTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSY 967

  Fly   731 CLCVQLCIMDSTVCLR---LEGTNELHFGHFLLTNCPFMILLVFIETTRRYFIRLFPDSWLELAT 792
            |       ....|.||   |:.|       :.....|:.:|:...:..|:..:|.:|..|:|..|
  Rat   968 C-------PGMGVALRMYPLKVT-------WWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKET 1018

  Fly   793 MY 794
            .|
  Rat  1019 YY 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	36/136 (26%)
		Cation_ATPase	190..284	CDD:289987	32/94 (34%)
		Cation_ATPase_C	582..777	CDD:295563	61/206 (30%)
Atp1a2	NP_036637.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		ATPase-IIC_X-K	30..1020	CDD:273445	254/845 (30%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..231
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850