Protein Alignment CG45062 and ATP13A2

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: XP_005245867.1
• Gene: ATP13A2 / 23400
• HGNCID: 30213
• Length: 1201
• Species: Homo sapiens
• Alignment Length: 842
• Identity: 170/842 - (20%)
• Similarity: 296/842 - (35%)
• Gaps: 261/842 - (30%)

  Fly    39 VGSMTDLCFKERSRSRSQKHQKQISYYMLLVAIVCFILLFLTTGFEHGHIVYEVNLSLLIGLTPV 103
            |.:.|..|..:.....|..|.:.|::..                ::|. :.:...||:|..|..:
Human   393 VVTRTGFCTAKGGLVSSILHPRPINFKF----------------YKHS-MKFVAALSVLALLGTI 440

  Fly   104 YLPFILYWGLRRTRKEMGRKQCHVRNLRATCTLGLSTVIVSD-LVGTMT------KRRMRVSEIF 161
            |..||||      |..:...:..:|      .|.|.||:|.. |...||      :.|:|...||
Human   441 YSIFILY------RNRVPLNEIVIR------ALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIF 493

  Fly   162 V------------------DMGLLSVDNLDVSAQSP----RFIELI------------RASVLCN 192
            .                  ..|.|:.|.|||....|    .|:.|:            ||...|:
Human   494 CIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGQAFLPLVPEPRRLPVGPLLRALATCH 558

  Fly   193 DAVICPGNIGVPKMQKDMYGNILDIALLK---------------FGLMIL---------PSIDLL 233
                     .:.::|....|:.:|:.:::               ||..:|         |.:..:
Human   559 ---------ALSRLQDTPVGDPMDLKMVESTGWVLEEEPAADSAFGTQVLAVMRPPLWEPQLQAM 614

  Fly   234 RHDHEKVANKHYNSEDKVQVTV-HRTRDADGHLKLVLL------------MKGHCEVVIRRCSTF 285
                         .|..|.|:| ||...:....::.::            :||..|:|...|:
Human   615 -------------EEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCN-- 664

  Fly   286 AIRDEELPLDEQLQEIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDY 350
               .|.:|.|      ...:......||..|.|.|.|.|          .....||..:...||.
Human   665 ---PETVPTD------FAQMLQSYTAAGYRVVALASKPL----------PTVPSLEAAQQLTRDT 710

  Fly   351 LAVDTYSLRFLGMIATYN---PPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAP 412
            :..|   |..||::...|   |..:.:.:|:.|.|   |:.::||....:.|..:|...|:: ||
Human   711 VEGD---LSLLGLLVMRNLLKPQTTPVIQALRRTR---IRAVMVTGDNLQTAVTVARGCGMV-AP 768

  Fly   413 SDTF-----------QAVNLKRMP---PTA--EVVDMSQYA------DEKPQHQR---------- 445
            .:..           |..:|:.:|   |||  .|.|..|.|      |.:.:|..
Human   769 QEHLIIVHATHPERGQPASLEFLPMESPTAVNGVKDPDQAASYTVEPDPRSRHLALSGPTFGIIV 833

  Fly   446 RHIEQLI--LNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSA 508
            :|..:|:  :..|..|.|..:.:|...:....::|...|.:.|...:|..|::::.||::
Human   834 KHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGIS----- 893

  Fly   509 VMCEASADLILLDTSFATLVS----VVGDSR----LLFENLKKALAYCLATNICNILVYLFFFLL 565
             :.:|.|.::...||....:.    |:.:.|    ..|...|....|.|...|..:::|.....|
Human   894 -LSQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNL 957

  Fly   566 GIPLYIHIMDELILAFLVNLV-----PALTL-IYEPPEENLMLQMPKVYDDFLLNSRLFFVSHIL 624
            |...::.|  :|::...|.::     |||.| ...||  ..:|.:| |....||  ::..|:.:.
Human   958 GDLQFLAI--DLVITTTVAVLMSRTGPALVLGRVRPP--GALLSVP-VLSSLLL--QMVLVTGVQ 1015

  Fly   625 VGTIEAAAVFMTYFVFMADKGFLP--RTLVAL-NIAWHDDMLDDITDSF-----------GQE-- 673
            :|         .||:.:|...|:|  ||:.|. |:..:::.:.....||           |..
Human  1016 LG---------GYFLTLAQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFR 1071

  Fly   674 ---WSSEARRQLECQVSSLCLMSLAVMQCTNLVLTKTGRANLL-----------AHGF-RNW 720
               :::|..|.:..::.:.......:.:......|:.|||.|.           |||. |:|
Human  1072 RPLYTNERARPVPPRLPAPPPAQAGLQEALQAAGTRAGRAALAAAARRPPEVVQAHGHPRHW 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	170/842 (20%)
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	158/784 (20%)