DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and Atp1a3

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	XP_011248820.1	Gene:	Atp1a3 / 232975	MGIID:	88107	Length:	1066	Species:	Mus musculus

Alignment Length:	824	Identity:	254/824 - (30%)
Similarity:	421/824 - (51%)	Gaps:	103/824 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFKERSRSRSQKHQK----QISYYMLL---VA 70
            |:....|:.:.|....|.:|.|..|.:|.:..|.      |..:..:.    :|.:::.|   ||
Mouse   244 NITFFSTNCVEGTARGVVVATGDRTVMGRIATLA------SGLEVGKTPIAIEIEHFIQLITGVA 302

  Fly    71 I---VCFILLFLTTG--------FEHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQ 124
            :   |.|.:|.|..|        |..|.||..|...||..:|..         |..|.|.|.||.
Mouse   303 VFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVC---------LTLTAKRMARKN 358

  Fly   125 CHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLD------VSAQSPRFIE 183
            |.|:||.|..|||.::.|.||..||:|:.||.|:.::.|..:...|..:      ....|..::.
Mouse   359 CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVA 423

  Fly   184 LIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSE 248
            |...:.|||.||...|...:|.:::|:.|:..:.||||...:...|:.|:|..::|||...:||.
Mouse   424 LSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNST 488

  Fly   249 DKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQEIILSLADGLLEAG 313
            :|.|:::|.|.|.:.: :.:|:|||..|.::.||:|..::.:|.||||:::|...:....|...|
Mouse   489 NKYQLSIHETEDPNDN-RYLLVMKGAPERILDRCATILLQGKEQPLDEEMKEAFQNAYLELGGLG 552

  Fly   314 RHVRAFAYKELSDELEFRRFS----QVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTI 374
            ..|..|.:..|.:|...:.|:    .||               ..|.:|.|:|:::..:|||:.:
Mouse   553 ERVLGFCHYYLPEEQFPKGFAFDCDDVN---------------FTTDNLCFVGLMSMIDPPRAAV 602

  Fly   375 PKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEV--------- 430
            |.||.:||:||||:|:||...|..|||:|..|||:...::|.:.:..:...|.::|
Mouse   603 PDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACV 667

  Fly   431 ---VDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDT 492
               .|:..:..|:       |::::.|..::|.|.||..|...|.:.|:|.||:|:|.|..::|:
Mouse   668 IHGTDLKDFTSEQ-------IDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDS 725

  Fly   493 PAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICN 555
            ||::.:.:|||.  .||.|..:| ||:||||.:||::|:.|.:.||:|:||||::||.|.:||..
Mouse   726 PALKKADIGVAMGIAGSDVSKQA-ADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPE 789

  Fly   556 ILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VYDDFLLNSRLFF 619
            |..:|.|.:..|||.:..:..|.:....::|||::|.||..|.::|.:.|: ...|.|:|.||..
Mouse   790 ITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLIS 854

  Fly   620 VSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLEC 684
            :::..:|.|:|...|.:|||.:|:.||||..||.:.:.|.|..::|:.||:||:|:.|.|:.:|.
Mouse   855 MAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEF 919

  Fly   685 QVSSLCLMSLAVMQCTNLVLTKTGRANLLAHGFRNWLL--------SLAVLLLICLCVQLCIMDS 741
            ...:...:|:.|:|..:|::.||.|.::...|.:|.:|        :||..|..|..     ||
Mouse   920 TCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPG-----MD- 978

  Fly   742 TVCLRLEGTN-ELHFGHFLLTNCPFMILLVFIETTRRYFIRLFP 784
             |.||:.... ...|..|     |:..|:...:..|:..:|..|
Mouse   979 -VALRMYPLKPSWWFCAF-----PYSFLIFVYDEIRKLILRRNP 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	37/136 (27%)
		Cation_ATPase	190..284	CDD:289987	33/93 (35%)
		Cation_ATPase_C	582..777	CDD:295563	62/204 (30%)
Atp1a3	XP_011248820.1	ATPase-IIC_X-K	31..1018	CDD:273445	254/824 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850