DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and eat-6

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_506269.1	Gene:	eat-6 / 179796	WormBaseID:	WBGene00001137	Length:	996	Species:	Caenorhabditis elegans

Alignment Length:	844	Identity:	255/844 - (30%)
Similarity:	425/844 - (50%)	Gaps:	128/844 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVG-----------SMTDLCFKERSRSRSQKHQKQISYYM 66
            |:....|:|:.|....:.:..|.||.:|           .||.:.             ::|.:::
Worm   219 NIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIA-------------REIEHFI 270

  Fly    67 LLVA-----------IVCFILLF--LT-TGFEHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTR 117
            .|:.           |:.|||.:  || ..|..|.||..|...|:..:|..         |..|.
Worm   271 HLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVC---------LTLTA 326

  Fly   118 KEMGRKQCHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLDV-SAQSPR- 180
            |.|..|.|.|:||.|..|||.::.|.||..||:|:.||.|:.::.|..:...|..:. ::|..|
Worm   327 KRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETQTSQEKRT 391

  Fly   181 ---FIELIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVAN 242
               |..|:|.:.|||.|....|....|.:::|..|:..:||||||..:...::..:|..::|:|.
Worm   392 GASFEALVRIASLCNRAEFKAGQQDTPILRRDCTGDASEIALLKFTELTQGNVIAVREKNKKIAE 456

  Fly   243 KHYNSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQ-------- 299
            ..:||.:|.||::|...|     ..:|:|||..|.::..|||..:..:|..|.::|:
Worm   457 IPFNSTNKYQVSIHDNGD-----HYLLVMKGAPERILDVCSTIFLNGKESELTDKLREDFNTAYL 516

  Fly   300 ------EIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSL 358
                  |.:|...|.:|.|.:..:.|.:     ::|     :||..|:               :|
Worm   517 ELGGMGERVLGFCDFVLPADKFPKGFKF-----DVE-----EVNFPLK---------------NL 556

  Fly   359 RFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKR 423
            ||:|:::..:|||:.:|.||.:||:||||:::||...|..|||:|..|||:...::|.:.:.::|
Worm   557 RFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTETVEDIAIRR 621

  Fly   424 MPPTAEV------------VDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACR 476
            ..|..||            .|:.:.::::       :.::|....::|.|.||..|...|.:..:
Worm   622 GIPVEEVNPREAKAAVIHGSDLREMSEDQ-------LAEIIKYHSEIVFARTSPQQKLMIVEGFQ 679

  Fly   477 RLGAVVSVIGGTLHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFE 539
            :.|.:|:|.|..::|:||::.:.:|||.  .||.|..:| ||:||||.:||::|..|.:.||:|:
Worm   680 KQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQA-ADMILLDDNFASIVVGVEEGRLIFD 743

  Fly   540 NLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQM 604
            ||||::||.|.:||..|..:|.:.|.||||.:..:..|.:....::|||::|.||..|.::|.:.
Worm   744 NLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQ 808

  Fly   605 PK-VYDDFLLNSRLFFVSHILVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITD 668
            |: ...|.|:|.||..:::..:|.|:|:|.|.|||..|||.||:|..|..|...|.....:::.|
Worm   809 PRDPIRDKLVNERLISLAYGQIGMIQASAGFFTYFWIMADNGFMPWDLYQLRAQWDSRAYNNVLD 873

  Fly   669 SFGQEWSSEARRQLECQVSSLCLMSLAVMQCTNLVLTKTGRANLLAHGFRNWLLSLAVLLLICLC 733
            |:||||:...|:.||....:...:|:.|:|..:|:::||.|.:|:..|..||.|:..::....|.
Worm   874 SYGQEWTYANRKILEYTCQTAYFVSIVVVQWADLIISKTRRNSLVQQGMSNWTLNFGLVFETALA 938

  Fly   734 VQLCI---MDSTVCLRLEGTNELHFGHFLLTNCPFMILLVFIETTRRYFIRLFPDSWLELATMY 794
            ..:|.   :|:.  ||:.|   |.|..:... .||.||:...:..||:.||.:|..|:|..|.|
Worm   939 WFMCYCPGLDNG--LRMYG---LRFSWWFCA-LPFSILIFVYDEIRRFLIRRYPGGWVERETYY 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	34/143 (24%)
		Cation_ATPase	190..284	CDD:289987	30/93 (32%)
		Cation_ATPase_C	582..777	CDD:295563	64/198 (32%)
eat-6	NP_506269.1	ATPase-IIC_X-K	6..996	CDD:273445	254/842 (30%)
		Cation_ATPase_N	18..92	CDD:214842
		E1-E2_ATPase	112..343	CDD:278548	35/145 (24%)
		Cation_ATPase	404..494	CDD:289987	31/94 (33%)
		COG4087	<644..725	CDD:226572	25/88 (28%)
		Cation_ATPase_C	772..981	CDD:279079	69/214 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850