DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45062 and mca-3

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_001380077.1	Gene:	mca-3 / 177089	WormBaseID:	WBGene00003153	Length:	1234	Species:	Caenorhabditis elegans

Alignment Length:	807	Identity:	180/807 - (22%)
Similarity:	308/807 - (38%)	Gaps:	183/807 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LACTHAISGIGFAVALACGRNTEVGSMTDLC---------------------------------- 46
            |:.||.:.|.|..:..|.|.|::.|.:..|.
Worm   231 LSGTHVMEGSGKMLVTAVGVNSQTGIIMTLLGAAKTVAEEERKTAKREGGDGASGAEEGTAQALL 295

  Fly    47 ---------------------FKERS--RSRSQKHQKQISY-------YMLLVAIVCFIL----- 76
                                 .||||  :::..:...||.|       ..:|:.|:.|.:
Worm   296 DSKGDEAMANGKAVAAAESDGKKERSVLQAKLTRLAIQIGYAGSFVAGCTVLILIIRFCISRYAI 360

  Fly    77 ---LFLTTGFEHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRNLRATCTLGL 138
               .|....|:|......:.:::|:...|..||..:...|..:.|:|......||:|.|..|:|.
Worm   361 DGKSFSLADFQHFINFLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMLDNNLVRHLDACETMGN 425

  Fly   139 STVIVSDLVGTMTKRRMRVSEIFVD----MGLLSVDNLDVSAQSPRFIELIRASVLCNDAVICPG 199
            :|.|.||..||:|..||.|.:.||:    .....:::||.:. :...::.|..:...:..||.|.
Worm   426 ATAICSDKTGTLTTNRMTVVQSFVNDVHYKDTPKIESLDQNT-AKLMMDCISINSSYSSQVIPPK 489

  Fly   200 NIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDH-EKVANKHY--NSEDKVQVTVHRTRDA 261
            .:|   .|....||..:..:|.|.|.:..|...:|..| |:...|.|  ||..|...||...  .
Worm   490 QLG---EQATQLGNKTECGMLGFVLALGKSYQEIRDRHPEETIPKVYTFNSVRKSMSTVINL--P 549

  Fly   262 DGHLKLVLLMKGHCEVVIRRCSTFAIRDEELP--LDEQLQEIILSLADGLLEAGRHVRAFAYKEL 324
            ||..:  :..||..|:|.:||..|..::..|.  ..:..:.::..:.:.:...|......|||:.
Worm   550 DGGYR--VFSKGASEIVTKRCKYFLGKNGTLTKFSSKDAENLVRDVIEPMASDGLRTICVAYKDY 612

  Fly   325 SDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLI 389
            ....:....:|:....| .:::..:.:..|..::..||:   .:|.|..:|.|:.||:.|||.:.
Worm   613 VPSSKKTADNQIAYSSE-PDWENEEMIVGDMTAIAVLGI---QDPVRPEVPAAITRCQEAGITVR 673

  Fly   390 VVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEVVDMSQYADEKPQHQRRHIEQLILN 454
            :||......|:::|...||| .|.:.|.|:..|..        .::..||..:..:..:: ||..
Worm   674 MVTGDNINTARSIATACGIL-KPGEDFIALEGKEF--------NARIRDENGEVSQEKLD-LIWP 728

  Fly   455 QQDLVCAATSTDQ---LHWIADACRRL---GAVVSVIGGTLHDTPAMRSSHVGVAK--YGSAVMC 511
            :..::..|..:|:   :..|.|:  |:   ..||:|.|...:|.||::.:.||.|.  .|:.|..
Worm   729 KLRVLARAQPSDKYVLVKGIIDS--RVTDSREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAK 791

  Fly   512 EASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVYLFFFLLGI---PLYIHI 573
            ||| |:||.|.:|.::|..|...|.:::::.|.|.:.|..|:..::| .|.....|   ||
Worm   792 EAS-DIILTDDNFTSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVVV-AFVGACAIQDTPL---- 850

  Fly   574 MDELILAFLVNLV----PALTLIYEPPEENLMLQMP-------------------KVYDDFLLNS 615
              :.:....|||:    .:|.|..|.|.|.|:.:.|                   .||...:|.:
Worm   851 --KAVQMLWVNLIMDTLASLALATEMPTEELLKRKPYGRTSPLISRTMCKNILGHAVYQLVILFT 913

  Fly   616 RLF------------------------------FVSHILVGTIEAAAVFMTYFVFMADKGFLPRT 650
            .:|                              ||...|...|.|..:.....:|   ||.....
Worm   914 LIFYGEVCFNIPSGRWAPLHSPPSKHFTIVFNTFVMMTLFNEINARKIHGERNIF---KGLFSNP 975

  Fly   651 LVALNIAWHDDMLDDIT-DSFGQEWSS 676
            :  ..:.|...|:..:. ..||..|.|
Worm   976 I--YYVIWIATMISQVVIIQFGGRWFS 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	33/187 (18%)
		Cation_ATPase	190..284	CDD:289987	29/96 (30%)
		Cation_ATPase_C	582..777	CDD:295563	28/149 (19%)
mca-3	NP_001380077.1	P-type_ATPase_Ca_PMCA-like	55..896	CDD:319776	162/696 (23%)
		Cation_ATPase_C	849..1026	CDD:376368	30/163 (18%)
		ATP_Ca_trans_C	1066..1108	CDD:403580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930