Protein Alignment CG45062 and mca-3

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_001380077.1
• Gene: mca-3 / 177089
• WormBaseID: WBGene00003153
• Length: 1234
• Species: Caenorhabditis elegans
• Alignment Length: 807
• Identity: 180/807 - (22%)
• Similarity: 308/807 - (38%)
• Gaps: 183/807 - (22%)

  Fly    16 LACTHAISGIGFAVALACGRNTEVGSMTDLC---------------------------------- 46
            |:.||.:.|.|..:..|.|.|::.|.:..|.
 Worm   231 LSGTHVMEGSGKMLVTAVGVNSQTGIIMTLLGAAKTVAEEERKTAKREGGDGASGAEEGTAQALL 295

  Fly    47 ---------------------FKERS--RSRSQKHQKQISY-------YMLLVAIVCFIL----- 76
                                 .||||  :::..:...||.|       ..:|:.|:.|.:
 Worm   296 DSKGDEAMANGKAVAAAESDGKKERSVLQAKLTRLAIQIGYAGSFVAGCTVLILIIRFCISRYAI 360

  Fly    77 ---LFLTTGFEHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRNLRATCTLGL 138
               .|....|:|......:.:::|:...|..||..:...|..:.|:|......||:|.|..|:|.
 Worm   361 DGKSFSLADFQHFINFLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMLDNNLVRHLDACETMGN 425

  Fly   139 STVIVSDLVGTMTKRRMRVSEIFVD----MGLLSVDNLDVSAQSPRFIELIRASVLCNDAVICPG 199
            :|.|.||..||:|..||.|.:.||:    .....:::||.:. :...::.|..:...:..||.|.
 Worm   426 ATAICSDKTGTLTTNRMTVVQSFVNDVHYKDTPKIESLDQNT-AKLMMDCISINSSYSSQVIPPK 489

  Fly   200 NIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDH-EKVANKHY--NSEDKVQVTVHRTRDA 261
            .:|   .|....||..:..:|.|.|.:..|...:|..| |:...|.|  ||..|...||...  .
 Worm   490 QLG---EQATQLGNKTECGMLGFVLALGKSYQEIRDRHPEETIPKVYTFNSVRKSMSTVINL--P 549

  Fly   262 DGHLKLVLLMKGHCEVVIRRCSTFAIRDEELP--LDEQLQEIILSLADGLLEAGRHVRAFAYKEL 324
            ||..:  :..||..|:|.:||..|..::..|.  ..:..:.::..:.:.:...|......|||:.
 Worm   550 DGGYR--VFSKGASEIVTKRCKYFLGKNGTLTKFSSKDAENLVRDVIEPMASDGLRTICVAYKDY 612

  Fly   325 SDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLI 389
            ....:....:|:....| .:::..:.:..|..::..||:   .:|.|..:|.|:.||:.|||.:.
 Worm   613 VPSSKKTADNQIAYSSE-PDWENEEMIVGDMTAIAVLGI---QDPVRPEVPAAITRCQEAGITVR 673

  Fly   390 VVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEVVDMSQYADEKPQHQRRHIEQLILN 454
            :||......|:::|...||| .|.:.|.|:..|..        .::..||..:..:..:: ||..
 Worm   674 MVTGDNINTARSIATACGIL-KPGEDFIALEGKEF--------NARIRDENGEVSQEKLD-LIWP 728

  Fly   455 QQDLVCAATSTDQ---LHWIADACRRL---GAVVSVIGGTLHDTPAMRSSHVGVAK--YGSAVMC 511
            :..::..|..:|:   :..|.|:  |:   ..||:|.|...:|.||::.:.||.|.  .|:.|..
 Worm   729 KLRVLARAQPSDKYVLVKGIIDS--RVTDSREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAK 791

  Fly   512 EASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVYLFFFLLGI---PLYIHI 573
            ||| |:||.|.:|.::|..|...|.:::::.|.|.:.|..|:..::| .|.....|   ||
 Worm   792 EAS-DIILTDDNFTSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVVV-AFVGACAIQDTPL---- 850

  Fly   574 MDELILAFLVNLV----PALTLIYEPPEENLMLQMP-------------------KVYDDFLLNS 615
              :.:....|||:    .:|.|..|.|.|.|:.:.|                   .||...:|.:
 Worm   851 --KAVQMLWVNLIMDTLASLALATEMPTEELLKRKPYGRTSPLISRTMCKNILGHAVYQLVILFT 913

  Fly   616 RLF------------------------------FVSHILVGTIEAAAVFMTYFVFMADKGFLPRT 650
            .:|                              ||...|...|.|..:.....:|   ||.....
 Worm   914 LIFYGEVCFNIPSGRWAPLHSPPSKHFTIVFNTFVMMTLFNEINARKIHGERNIF---KGLFSNP 975

  Fly   651 LVALNIAWHDDMLDDIT-DSFGQEWSS 676
            :  ..:.|...|:..:. ..||..|.|
 Worm   976 I--YYVIWIATMISQVVIIQFGGRWFS 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	180/807 (22%)
mca-3	NP_001380077.1	P-type_ATPase_Ca_PMCA-like	55..896	CDD:319776	162/696 (23%)
		Cation_ATPase_C	849..1026	CDD:376368	30/163 (18%)
		ATP_Ca_trans_C	1066..1108	CDD:463575