DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and Atp2b2

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	XP_030110982.1	Gene:	Atp2b2 / 11941	MGIID:	105368	Length:	1272	Species:	Mus musculus

Alignment Length:	836	Identity:	185/836 - (22%)
Similarity:	333/836 - (39%)	Gaps:	194/836 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RNTEVGSMTDLCFKERSRSRSQKHQKQIS-----------------YYMLLVAIVCFILLFLTTG 82
            ::.|.|...|       :.::..|:|:.|                 ..|..:.::..:|.|....
Mouse   363 KSAEGGDADD-------KKKANMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDT 420

  Fly    83 FEHG-----------HIVYEVNLSLLIGLT------PVYLPFILYWGLRRTRKEMGRKQCHVRNL 130
            |...           ::.|.|.. .:||:|      |..||..:...|..:.|:|.:....||:|
Mouse   421 FVVNKKPWLTECTPVYVQYFVKF-FIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL 484

  Fly   131 RATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV-DMGLLSVDNLDVSAQSPRFIELIRASVLCNDA 194
            .|..|:|.:|.|.||..||:|..||.|.:.:| |:....:.  |.|:.:.:.:||:..::..|.|
Mouse   485 DACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIP--DPSSINAKTLELLVNAIAINSA 547

  Fly   195 ----VICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANK----------HY 245
                ::.|...|....|   .||..:..||.|.|.       ||.|:|.|.::          .:
Mouse   548 YTTKILPPEKEGALPRQ---VGNKTECGLLGFVLD-------LRQDYEPVRSQMPEEKLYKVYTF 602

  Fly   246 NSEDKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRC----------STFAIRDEELPLDEQLQE 300
            ||..|...||.:..|.    ...:..||..|:|:::|          ..|..||.    ||.:::
Mouse   603 NSVRKSMSTVIKMPDE----SFRMYSKGASEIVLKKCCKILSGAGEARVFRPRDR----DEMVKK 659

  Fly   301 IILSLA-DGLLEAGRHVRAFAYKEL--SDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLG 362
            :|..:| |||     .....||::.  |.|.::...:.:                  ...|..:.
Mouse   660 VIEPMACDGL-----RTICVAYRDFPSSPEPDWDNENDI------------------LNELTCIC 701

  Fly   363 MIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPT 427
            ::...:|.|..:|:|:.:|:.|||.:.:||......|:|:|:..||: .|.:.|..:..|..
Mouse   702 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGII-HPGEDFLCLEGKEF--- 762

  Fly   428 AEVVDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQ---LHWIADACR-RLGAVVSVIGGT 488
                 ..:..:||.:.::..|:: |..:..::..::.||:   :..|.|:.. ....||:|.|..
Mouse   763 -----NRRIRNEKGEIEQERIDK-IWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDG 821

  Fly   489 LHDTPAMRSSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLAT 551
            .:|.||::.:.||.|.  .|:.|..||| |:||.|.:|:::|..|...|.:::::.|.|.:.|..
Mouse   822 TNDGPALKKADVGFAMGIAGTDVAKEAS-DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTV 885

  Fly   552 NICNILVYLFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPKVYDDFLLNSR 616
            |:..::|......:.....:..:..|.:..:::...:|.|..|||.|.|:|:.|...:..|::..
Mouse   886 NVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRT 950

  Fly   617 LFFVSHILVGTI-EAAAVFMTYFV----FMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSS 676
            :  :.:||...: :...:|...||    |..|.|        .|...|....:..|..|.
Mouse   951 M--MKNILGHAVYQLTLIFTLLFVGEKMFQIDSG--------RNAPLHSPPSEHYTIIFN----- 1000

  Fly   677 EARRQLECQVSSLCLMSLAVMQCTNLVLTKT--GRANLLAHGFRNWLLSLAVLLLICLCVQLCIM 739
                            :..:||..|.:..:.  |..|:....|||.:  ...::|....:|:.|:
Mouse  1001 ----------------TFVMMQLFNEINARKIHGERNVFDGIFRNPI--FCTIVLGTFAIQIVIV 1047

  Fly   740 D------STVCLRLE--------GTNELHFGHFLLTNCPFMILLVFIETTRRYFIR 781
            .      |...|:|:        |..||.:|..:.|          |.|:|..|::
Mouse  1048 QFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIAT----------IPTSRLKFLK 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	24/130 (18%)
		Cation_ATPase	190..284	CDD:289987	27/117 (23%)
		Cation_ATPase_C	582..777	CDD:295563	43/215 (20%)
Atp2b2	XP_030110982.1	ATPase-IIB_Ca	12..1087	CDD:273668	182/828 (22%)
Atp2b2	XP_030110982.1	ATP_Ca_trans_C	1126..1201	CDD:372101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930