Protein Alignment CG45062 and Atp2a2

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_001103610.1
• Gene: Atp2a2 / 11938
• MGIID: 88110
• Length: 1044
• Species: Mus musculus
• Alignment Length: 919
• Identity: 204/919 - (22%)
• Similarity: 372/919 - (40%)
• Gaps: 230/919 - (25%)

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTD-LCFKERSRSRSQKHQKQISYYM-LLVAIVCFI 75
            ||..:.|:..:|....|.:|.|.|||:|.:.| :...|:.|:..|:...:....: .:::::|..
Mouse   206 NMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA 270

  Fly    76 LLFLTTG----------FEHGHIVY-EVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRN 129
            :..:..|          :..|.|.| ::.::|.:...|..||.::...|....:.|.:|...||:
Mouse   271 VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS 335

  Fly   130 LRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFV----------------------DMGLLSVDNL 172
            |.:..|||.::||.||..||:|..:|.|..:|:                      .:|.:..|:.
Mouse   336 LPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFSITGSTYAPIGEVQKDDK 400

  Fly   173 DVSA-QSPRFIELIRASVLCNDAVI----CPG---NIG----------VPKMQKDMYGNILDIAL 219
            .|.. |....:||.....||||:.:    ..|   .:|          |.||      |:.|..|
Mouse   401 PVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM------NVFDTEL 459

  Fly   220 LKFGLMILPSIDLLRHDHEKVANKHYN---SEDKVQVTVHRTRDADGHLKL-VLLMKGHCEVVIR 280
            .  ||..:...:......:::..|.:.   |.|:..::|:.|.:......: .:.:||..|.||.
Mouse   460 K--GLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVID 522

  Fly   281 RCSTFAIRDEELPLDEQLQEIILSLADGLLEAGRHVRAFAYKELSDELEFRRFSQVNTGLEGGEY 345
            ||:...:...::|:...:::.|:|:   :.|.|..         ||.|.....:..:..|:..|.
Mouse   523 RCTHIRVGSTKVPMTPGVKQKIMSV---IREWGSG---------SDTLRCLALATHDNPLKREEM 575

  Fly   346 KYRD---YLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVG 407
            ...|   ::..:| :|.|:|.:...:|||..:..:|..||.|||::|::|......|.|:...:|
Mouse   576 HLEDSANFIKYET-NLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIG 639

  Fly   408 ILPAPSD----TFQAVNLKRMPPTAE---VVDMSQYADEKPQHQRRHIEQLILNQQDLVCAATST 465
            |.....|    .|.......:.|:|:   .::...:|..:|.|:.:.:|.|           .|.
Mouse   640 IFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFL-----------QSF 693

  Fly   466 DQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVMCEASADLILLDTSFATLVSV 530
            |:             :.::.|..::|.||::.|.:|:|......:.:.:::::|.|.:|:|:|:.
Mouse   694 DE-------------ITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAA 745

  Fly   531 VGDSRLLFENLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFL--VNLV----PAL 589
            |.:.|.::.|:|:.:.|.:::|:..::.......||.|      :.||...|  ||||    ||.
Mouse   746 VEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFP------EALIPVQLLWVNLVTDGLPAT 804

  Fly   590 TLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILVG------TIEAAAVFMTYFVFMADKG--- 645
            .|.:.||:.::|.:.|:...:.|::..||| .::.:|      |:.|||    ::...||.|
Mouse   805 ALGFNPPDLDIMNKPPRNPKEPLISGWLFF-RYLAIGCYVGAATVGAAA----WWFIAADGGPRV 864

  Fly   646 -------FL---------------------PRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQL 682
                   ||                     |.|: ||::....:|.:.:..      .||.:..|
Mouse   865 SFYQLSHFLQCKEDNPDFDGVDCAIFESPYPMTM-ALSVLVTIEMCNALNS------LSENQSLL 922

  Fly   683 ECQ-------VSSLCL-MSL-----------AVMQCTNLVLTKTGRANLLAHGFRNWLLSLAVLL 728
            ...       |.|:|| |||           .:.|.|.|.||:             ||:.|.:.|
Mouse   923 RMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQ-------------WLMVLKISL 974

  Fly   729 LICL-------------------CVQLCIMDSTVCLRLEGTNELHFGHFLLTNCPFMILLVFIET 774
            .:.|                   |||.....|  |.....|:.:.:...||    .|.|:|::.:
Mouse   975 PVILMDETLKFVARNYLEQPGKECVQPATKSS--CSLSACTDGISWPFVLL----IMPLVVWVYS 1033

  Fly   775 TRRYFIRLF 783
            |...|..:|
Mouse  1034 TDTNFSDMF 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	204/919 (22%)
Atp2a2	NP_001103610.1	P-type_ATPase_SERCA	5..988	CDD:319778	190/857 (22%)
		Interaction with HAX1. /evidence=ECO:0000250	575..594		4/19 (21%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	787..807		8/19 (42%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000269|PubMed:23395171	788..1044		65/286 (23%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	931..942		5/10 (50%)