Protein Alignment CG45062 and Atp1a1

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_659149.1
• Gene: Atp1a1 / 11928
• MGIID: 88105
• Length: 1023
• Species: Mus musculus
• Alignment Length: 833
• Identity: 248/833 - (29%)
• Similarity: 413/833 - (49%)
• Gaps: 101/833 - (12%)

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTDLCFKERSRSRSQKHQ----KQISYYMLL---VA 70
            |:....|:.:.|....:.:..|..|.:|.:..|.      |..:..|    ::|.:::.|   ||
Mouse   241 NIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLA------SGLEGGQTPIAEEIEHFIHLITGVA 299

  Fly    71 I---VCFILLFL--------TTGFEHGHIVYEVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQ 124
            :   |.|.:|.|        ...|..|.||..|...||..:|..         |..|.|.|.||.
Mouse   300 VFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVC---------LTLTAKRMARKN 355

  Fly   125 CHVRNLRATCTLGLSTVIVSDLVGTMTKRRMRVSEIFVDMGLLSVD------NLDVSAQSPRFIE 183
            |.|:||.|..|||.::.|.||..||:|:.||.|:.::.|..:...|      .:.....|..:..
Mouse   356 CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWFA 420

  Fly   184 LIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALLKFGLMILPSIDLLRHDHEKVANKHYNSE 248
            |.|.:.|||.||.......:|.:::.:.|:..:.||||...:...|:..:|..:.|:....:||.
Mouse   421 LSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIEVCCGSVMEMREKYSKIVEIPFNST 485

  Fly   249 DKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQEIILSLADGLLEAG 313
            :|.|:::|:..:| ...|.:|:|||..|.::.|||:..:..:|.||||:|::...:....|...|
Mouse   486 NKYQLSIHKNPNA-SEPKHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLG 549

  Fly   314 RHVRAFAYKELSDELEFRRFSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAV 378
            ..|..|.:..|.|| :|....|.:|          |.:.....:|.|:|:|:..:|||:.:|.||
Mouse   550 ERVLGFCHLLLPDE-QFPEGFQFDT----------DDVNFPVDNLCFVGLISMIDPPRAAVPDAV 603

  Fly   379 DRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEV------------V 431
            .:||:||||:|:||...|..|||:|..|||:...::|.:.:..:...|..:|            .
Mouse   604 GKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQVNPRDAKACVVHGS 668

  Fly   432 DMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMR 496
            |:.....|:       ::.::....::|.|.||..|...|.:.|:|.||:|:|.|..::|:||::
Mouse   669 DLKDMTSEE-------LDDILRYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALK 726

  Fly   497 SSHVGVAK--YGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVY 559
            .:.:|||.  .||.|..:| ||:||||.:||::|:.|.:.||:|:||||::||.|.:||..|..:
Mouse   727 KADIGVAMGIVGSDVSKQA-ADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPF 790

  Fly   560 LFFFLLGIPLYIHIMDELILAFLVNLVPALTLIYEPPEENLMLQMPK-VYDDFLLNSRLFFVSHI 623
            |.|.:..|||.:..:..|.:....::|||::|.||..|.::|.:.|: ...|.|:|.||..:::.
Mouse   791 LIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYG 855

  Fly   624 LVGTIEAAAVFMTYFVFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLECQVSS 688
            .:|.|:|...|.||||.:|:.||||..|:.:...|.|..::|:.||:||:|:.|.|:.:|....:
Mouse   856 QIGMIQALGGFFTYFVILAENGFLPFHLLGIRETWDDRWVNDVEDSYGQQWTYEQRKIVEFTCHT 920

  Fly   689 LCLMSLAVMQCTNLVLTKTGRANLLAHGFRNWLL--------SLAVLLLIC----LCVQLCIMDS 741
            ...:|:.|:|..:||:.||.|.::...|.:|.:|        :||..|..|    ..:::..:..
Mouse   921 AFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGAALRMYPLKP 985

  Fly   742 TVCLRLEGTNELHFGHFLLTNCPFMILLVFIETTRRYFIRLFPDSWLELATMY 794
            |               :.....|:.:|:...:..|:..||..|..|:|..|.|
Mouse   986 T---------------WWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	247/831 (30%)
Atp1a1	NP_659149.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39
		ATPase-IIC_X-K	29..1023	CDD:273445	247/831 (30%)
		Phosphoinositide-3 kinase binding. /evidence=ECO:0000250	82..84
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..235
		Mediates interaction with SCN7A. /evidence=ECO:0000269|PubMed:17408578	596..717		38/127 (30%)