DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45062 and Atp2a1

DIOPT Version :9

Sequence 1:	NP_001286726.1	Gene:	CG45062 / 19835139	FlyBaseID:	FBgn0266432	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	XP_038966815.1	Gene:	Atp2a1 / 116601	RGDID:	621293	Length:	1001	Species:	Rattus norvegicus

Alignment Length:	873	Identity:	181/873 - (20%)
Similarity:	351/873 - (40%)	Gaps:	207/873 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NMGLACTHAISGIGFAVALACGRNTEVGSMTD-LCFKERSRSRSQKHQKQISYYM-LLVAIVCFI 75
            ||..:.|:..:|....:....|.:||:|.:.| :...|:.::..|:...:....: .:::::|..
  Rat   206 NMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVA 270

  Fly    76 LLFLTTG----------FEHGHIVY-EVNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRN 129
            :..:..|          :..|.|.| ::.::|.:...|..||.::...|....:.|.:|...||:
  Rat   271 VWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS 335

  Fly   130 LRATCTLGLSTVIVSDLVGTMTKRRMRVSEIF----VDMGLLSVDNLDV--SAQSPR-------- 180
            |.:..|||.::||.||..||:|..:|.|.::|    ||..:.|::...:  |..:|.
  Rat   336 LPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICSLNEFSITGSTYAPEGEVLKNDK 400

  Fly   181 ---------FIELIRASVLCNDAVICPGNIGVPKMQKDMYGNILDIALL----KFGLMILPSIDL 232
                     .:||.....||||:.:   :....|...:..|...:.||.    |..:.......|
  Rat   401 PVRAGQYDGLVELATICALCNDSSL---DFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRSL 462

  Fly   233 LRHDHEKVAN--------KHYN---SEDKVQVTVH-----RTRDADGHLKLVLLMKGHCEVVIRR 281
            .:.:.....|        |.:.   |.|:..::|:     .:|.|.|:   .:.:||..|.||.|
  Rat   463 SKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGN---KMFVKGAPEGVIDR 524

  Fly   282 CSTFAIRDEELPLDEQLQEIILSLADGLLEAGR-----HVRAFAYKE---------LSDELEFRR 332
            |:...:....:||...::|.|:|:   :.|.|.     ...|.|.::         |.|..:|..
  Rat   525 CNYVRVGTTRVPLTGPVKEKIMSV---IKEWGTGRDTLRCLALATRDTPPKREEMVLDDSAKFME 586

  Fly   333 FSQVNTGLEGGEYKYRDYLAVDTYSLRFLGMIATYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPK 397
            :..                     .|.|:|::...:|||..:..::..||.|||::|::|.....
  Rat   587 YEM---------------------DLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKG 630

  Fly   398 MAKALAVDVGILPAPSDTFQAVNLKRM---PPTAEVVDMSQ----YADEKPQHQRRHIEQLILNQ 455
            .|.|:...:||.....:........|.   .|.||..:..:    :|..:|.|:.:.:|.|
  Rat   631 TAIAICRRIGIFSENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYL---- 691

  Fly   456 QDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAMRSSHVGVAKYGSAVMCEASADLILL 520
                   .|.|:             :.::.|..::|.||::.:.:|:|......:.:.:::::|.
  Rat   692 -------QSYDE-------------ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLA 736

  Fly   521 DTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVYLFFFLLGIPLYIHIMDELILAFL--V 583
            |.:|:|:|:.|.:.|.::.|:|:.:.|.:::|:..::.......||:|      :.||...|  |
  Rat   737 DDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLP------EALIPVQLLWV 795

  Fly   584 NLV----PALTLIYEPPEENLMLQMPKVYDDFLLNSRLFFVSHILVG------TIEAAAVFMTYF 638
            |||    ||..|.:.||:.::|.:.|:...:.|::..||| .::.:|      |:.|||.:..|
  Rat   796 NLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFF-RYMAIGGYVGAATVGAAAWWFLY- 858

  Fly   639 VFMADKGFLPRTLVALNIAWHDDMLDDITDSFGQEWSSEARRQLECQV------SSLCLMSLAVM 697
               |:.|  |      ::::|     .:|........:.....|:|:|      .::.|..|..:
  Rat   859 ---AEDG--P------HVSYH-----QLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVTI 907

  Fly   698 QCTNLVLTKTGRANLL--AHGFRNWLLSLAVLLLICLCVQLCIMDSTVCLRLEGTNELHFGHFLL 760
            :..|.:.:.:...:||  ......|||                  .::||.:    .|||....:
  Rat   908 EMCNALNSLSENQSLLRMPPWVNIWLL------------------GSICLSM----SLHFLILYV 950

  Fly   761 TNCPFMILLVFIETTRRYFIRLFPDSWL 788
            ...|.:..|..::.|:          ||
  Rat   951 DPLPMIFKLRALDFTQ----------WL 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	E1-E2_ATPase	<13..132	CDD:278548	26/131 (20%)
		Cation_ATPase	190..284	CDD:289987	25/113 (22%)
		Cation_ATPase_C	582..777	CDD:295563	46/214 (21%)
Atp2a1	XP_038966815.1	P-type_ATPase_SERCA	5..989	CDD:319778	181/873 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42861
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010