Protein Alignment CG45062 and atp7a

DIOPT Version :10

• Sequence 1: NP_001286726.1
• Gene: CG45062 / 19835139
• FlyBaseID: FBgn0266432
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_001361526.1
• Gene: atp7a / 100170482
• XenbaseID: XB-GENE-1010489
• Length: 1501
• Species: Xenopus tropicalis
• Alignment Length: 630
• Identity: 119/630 - (18%)
• Similarity: 222/630 - (35%)
• Gaps: 185/630 - (29%)

  Fly    37 TEVGSMTDLC-------FKERSRSRSQKHQKQISYYML--LVAI-VCFILLFLTTGFEHGHIVYE 91
            |.|||.|.|.       ..:.|::..|:...::|.|.:  :||: |..:.:::..|:.:..||.:
 Frog   909 THVGSDTTLSQIVKLVEDAQTSKAPIQQFADKLSGYFVPFIVAVSVLTLFVWIIIGYHNFEIVEK 973

  Fly    92 ----VNLSLLIGLTPVYLPFILYWGLRRTRKEMGRKQCHVRNLRATCTLGLST------------ 140
                .|.|:..|...|...|              :....|..:...|:|||:|
 Frog   974 YFPGYNKSISKGEVIVRFAF--------------QAAITVLCIACPCSLGLATPTAVMVGTGVGA 1024

  Fly   141 -------------------VIVSDLVGTMTKRRMRVSEIFVDMGLLSVDNLDVSAQSPRFIELIR 186
                               .:|.|..||:||            |...|..:.|..:|.|.
 Frog  1025 QNGILIKGGEPLEMAHKVKTVVFDKTGTITK------------GTPVVMQVKVLVESNRM----- 1072

  Fly   187 ASVLCNDAVICPGN-----IGVPKMQKDMYGNILDIALLKFGLMILPSIDL-LRHDHEKVANKHY 245
                       |.|     :|..:...:   :.|..|::|:...:|.:..| ..:|.:.|.....
 Frog  1073 -----------PSNKLLAIVGTAESNSE---HPLGSAVIKYCKEVLNAETLGTCYDFQAVPGCGI 1123

  Fly   246 NSE-DKVQVTVHRTRDADGHLKLVLLMKGHCEVVIRRCSTFAIRDEELPLDEQLQEIIL-SLADG 308
            :.: :.::..:|.....|.....||:.                      :|.|.::.|| |:...
 Frog  1124 SCKVNNIEPLLHAANGPDNKRNAVLVQ----------------------IDGQHEDSILPSITVS 1166

  Fly   309 LLEAGRHVRAFAYKELSDELEF--RRF----SQVNTGLEGGEYKYRD--YLAVDTYSLRFLGMIA 365
            ...:........|..|....|:  |.|    ::.::.:...|.|.|.  .:|||..   ..|:||
 Frog  1167 QNPSNGSSPPQTYSVLIGNREWMNRNFLTLTAETDSLMTEHEKKGRTAVLVAVDGV---LCGLIA 1228

  Fly   366 TYNPPRSTIPKAVDRCRAAGIKLIVVTQRKPKMAKALAVDVGILPAPSDTFQAVNLKRMPPTAEV 430
            ..:..:.....|:...|:.|:.::::|....|.||.:|..|||...
 Frog  1229 IADTVKPEAALAIHSLRSMGLDIVLMTGDNSKTAKTIAAQVGITKV------------------- 1274

  Fly   431 VDMSQYADEKPQHQRRHIEQLILNQQDLVCAATSTDQLHWIADACRRLGAVVSVIGGTLHDTPAM 495
                 :|:..|.|:...::||                        :..|..|:::|..::|:||:
 Frog  1275 -----FAEVLPSHKVAKVKQL------------------------QEQGTRVAMVGDGINDSPAL 1310

  Fly   496 RSSHVGVA-KYGSAVMCEASADLILLDTSFATLVSVVGDSRLLFENLKKALAYCLATNICNILVY 559
            ..:.||:. ..|:.|..|| ||::|:......:|:.:..||...:.::....:.|..|:..|.:.
 Frog  1311 AMADVGITIGSGTDVAIEA-ADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIA 1374

  Fly   560 LFFFL-LGIPLYIHIMDELILAFLVNLVPA---LTLIYEPPEENL 600
            ...|: :|:.|...:....:.|..|::|.:   |.|..:|..|.|
 Frog  1375 AGVFMPVGLILQPWMGSAAMAASSVSVVFSSLLLKLYRKPSREKL 1419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45062	NP_001286726.1	ATPase-IIC_X-K	<13..794	CDD:273445	119/630 (19%)
atp7a	NP_001361526.1	HMA	12..74	CDD:238219
		CopZ	171..232	CDD:442020
		HMA	279..336	CDD:238219
		HMA	384..447	CDD:238219
		HMA	497..559	CDD:238219
		HMA	572..632	CDD:238219
		P-type_ATPase_Cu-like	657..1389	CDD:319783	111/598 (19%)