DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rlim and CG6923

DIOPT Version :9

Sequence 1:	NP_001345134.1	Gene:	Rlim / 19820	MGIID:	1342291	Length:	600	Species:	Mus musculus
Sequence 2:	NP_001262484.1	Gene:	CG6923 / 41420	FlyBaseID:	FBgn0037944	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	712	Identity:	154/712 - (21%)
Similarity:	230/712 - (32%)	Gaps:	248/712 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse    42 DYRLMRDNNLLGTPGESTEEELLRRLQQIKEG--PPPQSPDENRAGESSDDVTNSDSIIDWLNSV 104
            |.:|.||.:    .|...|.|..|..:..:..  |.|:.|:|:|.       |..|....: ...
  Fly   599 DTQLQRDRD----RGRERERERARDREPYRNDTQPNPEDPNEDRR-------TMYDCAYTF-PYA 651

Mouse   105 RQTGNTTRSGQRG--------------------NQSWRAVSRTNPNSGDF-----------RFSL 138
            |:|...|.:...|                    |.|:......:|..|:|           |:.|
  Fly   652 RRTDRRTEANNEGTSAFAFYSGALADRAAISDHNYSYELDQLMDPGPGNFYPPRCSNMDPQRYFL 716

Mouse   139 EINVNRNNGSQTS----------------------ENESEPSTRRLSVENMESSSQRQMENSASE 181
            .||       ::|                      :|.|..:..|....|:.|:.    .:|:||
  Fly   717 PIN-------ESSMWMPGHPAPPPPPPPMPPILLPDNSSTEAYLRHQQRNLTSTP----SSSSSE 770

Mouse   182 SASARPSRAERNSAE-----------AVTEVPTTRAQRRARSRSPEHRRTRARAERSRSP-LQPT 234
            ..|.:.||..|:|..           |:|.:||.                   .|....| |||.
  Fly   771 QTSTQQSRHRRSSPANVYHRYHPYYYAITTLPTV-------------------VESDYPPSLQPH 816

Mouse   235 SEIPRRAPTLEQSSENEPEGSSRTRHHVTLRQQISGPELLGRGLFAASGSRNPSQGTSSSDTGSN 299
               |...|..:.|.    .||||:        .:||  .|.....||:.:  ..|..:.||..|.
  Fly   817 ---PHPHPHFQPSQ----GGSSRS--------SLSG--ALNAAAVAATAA--AVQAQTFSDLLSQ 862

Mouse   300 SESSG-----SGQR-PPTIVLDLQVRRVRPGEYRQRDSI-------ASRTR-------------- 337
            :.:.|     .|.| ||..::..|        ::||.||       ||...
  Fly   863 AHNEGRAAALEGNRTPPHTMVHAQ--------HQQRQSINPPAPGVASNANLAAAVSPPPPLEMY 919

Mouse   338 -SRSQAPN----------NTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIR--RILNTGLSE 389
             .||..|:          :...| |.|..::....:..:|......:.|..|.|  .|:.|.|:.
  Fly   920 SGRSTIPHCGSPPFSVRRSEAAY-SNRQHYQPQPHQGHQAPQNQMHAHIHPPHRASAIVATSLTP 983

Mouse   390 T-----------TSVAIQTMLRQIMTGFG-ELSYFMYSDSDSEPSASVSSRN------VERVESR 436
            .           ...::|.|.|:.||... :|       |.:.|..:.:.||      ...|.:|
  Fly   984 APPYPVHQNLWYRQQSMQEMHRRHMTPTPIDL-------SSNAPLLTSTLRNGYLHSICSCVHAR 1041

Mouse   437 NGRGSS-------------GGGNSSGSSSSSSPSPSSSGESSESSSEMFEGSSEGGSSGPSRRDG 488
            ||..||             .......|....||:.|.||.||.::..............|..:..
  Fly  1042 NGPVSSLDPAYYPPYDAAPAAAAPPPSPQQQSPATSGSGNSSVAAQASMRHLQLQPQQQPQAQQS 1106

Mouse   489 -------------------RHRAPVTFDESGSLPFLSLAQFFLLNEDDEDQPRGLTKEQID---- 530
                               .|.:|:.. |.|..| |||....|:.....:  ||.|.|.|:
  Fly  1107 PPVMQHMQRQRAIHHHMFHHHYSPLHL-EIGLAP-LSLGSRILIAPSRPN--RGATLETIERNTL 1167

Mouse   531 -----NLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICR 587
                 .:...|..:.||.| |::|:..:...|::|:|||.|.:|..|:|:||..|..|||||
  Fly  1168 PHKYRRVRRPSETDEDAEK-CAICLNLFEIENEVRRLPCMHLFHTDCVDQWLVTNKHCPICR 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlim	NP_001345134.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..355		81/410 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..497		21/117 (18%)
		RING_Ubox	544..588	CDD:388418	20/44 (45%)
		PDZ-binding. /evidence=ECO:0000255	597..600
CG6923	NP_001262484.1	zf-rbx1	<1185..1228	CDD:289448	18/43 (42%)
CG6923	NP_001262484.1	zf-RING_2	1187..1228	CDD:290367	17/40 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910