Protein Alignment EIF4G1 and Paip1

DIOPT Version :10

• Sequence 1: NP_001181875.2
• Gene: EIF4G1 / 1981
• HGNCID: 3296
• Length: 1606
• Species: Homo sapiens
• Sequence 2: NP_611180.1
• Gene: Paip1 / 36913
• FlyBaseID: FBgn0034181
• Length: 559
• Species: Drosophila melanogaster
• Alignment Length: 357
• Identity: 71/357 - (19%)
• Similarity: 129/357 - (36%)
• Gaps: 104/357 - (29%)

Human   742 KPSSKRTAADKDRGEEDADGSKT--QDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGV 804
            :||:...||.............|  .:....|...||: .|..|..:..:...: .|..|..:.|
  Fly   245 QPSTSTAAASSSSSNSSQPDMATIALEYLDTVIHCLNQ-NPGQFDSIASRFLTI-FDGMENNQFV 307

Human   805 IDL----IFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDD 865
            :.:    ||||:|.:|||....|.:...|..|    ..||...  |..||  :|:.::.
  Fly   308 LSIAMEDIFEKSIEQPNFRYMGAKLYNLLHML----NSKPDSL--FHTLL--KCKLDYH------ 358

Human   866 EVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELF---------KLKMLTEA 921
                  |:|:.:...:.|:.:::|               ...|:.||:         :::::...
  Fly   359 ------QEEVTKYMRSNEQQKVRE---------------TALFLAELYMQLRGDDDSRIQLIAVN 402

Human   922 IMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFML 986
            |::. :.|||.:...|::.|||:.|...|.||..:..|. :.:....::.|  |.|:..:.. |.
  Fly   403 IVYS-LSKLLASESNENVRCLCQTLKLAGYDLTADCPKD-IQEIITALQAI--ELKSPGKYP-MA 462

Human   987 QDVLDLRGSNW-----------------VPRRGDQ----GPK----TIDQ--------------- 1011
            ..|:.|:.:||                 .||..|:    ||.    |.::
  Fly   463 ASVIALQQNNWGRKVSNALGDDEDTVKEPPRLSDEPVFYGPDGRELTAEETDFLAGGDNDGDDDF 527

Human  1012 ------IHKEAEMEEHREHIKVQQLMAKGSDK 1037
                  :..:|||:|..|. ..::...:|..|
  Fly   528 DGDGADLEIDAEMDEETER-AYKEFCKQGKQK 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF4G1	NP_001181875.2	PHA03247	<21..583	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..229
		PABPC1-binding	179..207
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..326
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..607
		EIF4E-binding	614..625
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	674..720
		eIF3/EIF4A-binding	689..1092		71/357 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..764		4/21 (19%)
		MIF4G	768..993	CDD:397130	50/237 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1031..1234		2/7 (29%)
		MA3	1249..1361	CDD:397128
		W2_eIF4G1_like	1445..1577	CDD:211397
		EIF4A-binding	1457..1606
		Necessary but not sufficient for MKNK1-binding	1592..1606
Paip1	NP_611180.1	MIF4G	270..472	CDD:214713	51/243 (21%)