Protein Alignment EIF4EBP2 and Thor

DIOPT Version :10

• Sequence 1: NP_004087.1
• Gene: EIF4EBP2 / 1979
• HGNCID: 3289
• Length: 120
• Species: Homo sapiens
• Sequence 2: NP_477295.1
• Gene: Thor / 33569
• FlyBaseID: FBgn0261560
• Length: 117
• Species: Drosophila melanogaster
• Alignment Length: 131
• Identity: 48/131 - (36%)
• Similarity: 73/131 - (55%)
• Gaps: 25/131 - (19%)

Human     1 MSSSAGSGHQPSQSRAIPTRTVAISDAAQLPHDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNS 65
            ||:|..:....:|:..:.||.|.|||..|:|..|.:||||||:|||||||::||:|.|:.:.|.|
  Fly     1 MSASPTARQAITQALPMITRKVVISDPIQMPEVYSSTPGGTLYSTTPGGTKLIYERAFMKNLRGS 65

Human    66 PMAQTPPCHLPN--IPG---------VTSPGTLIEDSKVEVNNLNNLNNHDRKHAVGDDAQFEMD 119
            |::||||.::|:  :.|         |..|..||:.:|              ...:.|..||::|
  Fly    66 PLSQTPPSNVPSCLLRGTPRTPFRKCVPVPTELIKQTK--------------SLKIEDQEQFQLD 116

Human   120 I 120
            :
  Fly   117 L 117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF4EBP2	NP_004087.1	Disordered. /evidence=ECO:0000305|PubMed:24207126, ECO:0000305|PubMed:25533957	1..48		22/46 (48%)
		eIF_4EBP	11..120	CDD:461656	44/119 (37%)
		YXXXXLphi motif. /evidence=ECO:0000269|PubMed:24207126, ECO:0000269|PubMed:25533957	54..60		3/5 (60%)
		Disordered. /evidence=ECO:0000305|PubMed:24207126, ECO:0000305|PubMed:25533957	65..120		16/65 (25%)
		Secondary EIF4E binding site. /evidence=ECO:0000269|PubMed:24207126, ECO:0000269|PubMed:25533957	78..82		1/12 (8%)
		TOS motif. /evidence=ECO:0000250|UniProtKB:Q13541	116..120		1/3 (33%)
Thor	NP_477295.1	eIF_4EBP	9..117	CDD:461656	44/121 (36%)