DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EIF4E and eIF4E1

DIOPT Version :9

Sequence 1:	NP_001124151.1	Gene:	EIF4E / 1977	HGNCID:	3287	Length:	248	Species:	Homo sapiens
Sequence 2:	NP_001261626.1	Gene:	eIF4E1 / 45525	FlyBaseID:	FBgn0015218	Length:	259	Species:	Drosophila melanogaster

Alignment Length:	273	Identity:	109/273 - (39%)
Similarity:	140/273 - (51%)	Gaps:	60/273 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     3 TVEPETTP-TPNPPTT--------EEEKTESNQEVANP------------------EHYIKHPLQ 40
            |..|.|.. .|.|||:        :.:..|..||...|                  ||..||||.
  Fly    20 TSAPSTEQGRPEPPTSAAAPAEAKDVKPKEDPQETGEPAGNTATTTAPAGDDAVRTEHLYKHPLM 84

Human    41 NRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDE 105
            |.|.||:.:||:||:|:.....|:.||||||||:|||||:..|.:..|.||||||..|.|||||.
  Fly    85 NVWTLWYLENDRSKSWEDMQNEITSFDTVEDFWSLYNHIKPPSEIKLGSDYSLFKKNIRPMWEDA 149

Human   106 KNKRGGRWLITLNKQQRRSDLDRFWLETRWDLAMLPRLVSNFWPQVILPLQPPKVLELQLLCLIG 170
            .||:||||:|||||.. ::|||..||:.                               ||||||
  Fly   150 ANKQGGRWVITLNKSS-KTDLDNLWLDV-------------------------------LLCLIG 182

Human   171 ESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTA 235
            |:| |:||.:||||:|:|.|.:||:|||.:..|.||...||...::.|.|.....:.||.|.||.
  Fly   183 EAF-DHSDQICGAVINIRGKSNKISIWTADGNNEEAALEIGHKLRDALRLGRNNSLQYQLHKDTM 246

Human   236 TKSGSTTKNRFVV 248
            .|.||..|:.:.:
  Fly   247 VKQGSNVKSIYTL 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EIF4E	NP_001124151.1	IF4E	38..228	CDD:366742	85/189 (45%)
eIF4E1	NP_001261626.1	IF4E	82..239	CDD:366742	85/189 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140836
Domainoid	1	1.000	187	1.000	Domainoid score	I3336
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	214	1.000	Inparanoid score	I3630
Isobase	1	0.950	-	0	Normalized mean entropy	S964
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm8454
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	LDO	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750