Protein Alignment EIF4A2 and TIF1

DIOPT Version :10

• Sequence 1: NP_001958.2
• Gene: EIF4A2 / 1974
• HGNCID: 3284
• Length: 407
• Species: Homo sapiens
• Sequence 2: NP_012985.3
• Gene: TIF1 / 853933
• SGDID: S000001767
• Length: 395
• Species: Saccharomyces cerevisiae
• Alignment Length: 407
• Identity: 257/407 - (63%)
• Similarity: 320/407 - (78%)
• Gaps: 13/407 - (3%)

Human     1 MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAII 65
            ||.|..|..           :..|::|::::|..||||.|.|:||||::.||||:|||||||||:
Yeast     1 MSEGITDIE-----------ESQIQTNYDKVVYKFDDMELDENLLRGVFGYGFEEPSAIQQRAIM 54

Human    66 PCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGA 130
            |.|:|:||:||||||||||.||:|:.||:::...|..|||:||||||||.|||||::||..:|..
Yeast    55 PIIEGHDVLAQAQSGTGKTGTFSIAALQRIDTSVKAPQALMLAPTRELALQIQKVVMALAFHMDI 119

Human   131 TCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKD 195
            ..|||||||:...:.:.|:  ...|||||||||||.:.||......||||:|||||||||.|||:
Yeast   120 KVHACIGGTSFVEDAEGLR--DAQIVVGTPGRVFDNIQRRRFRTDKIKMFILDEADEMLSSGFKE 182

Human   196 QIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWK 260
            |||:||..|..:.||||||||||.||||||.||||:|:||||||:|||||||||||:|||.||:|
Yeast   183 QIYQIFTLLPPTTQVVLLSATMPNDVLEVTTKFMRNPVRILVKKDELTLEGIKQFYVNVEEEEYK 247

Human   261 LDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSR 325
            .:.|.|||:::::||||||.||||||:.||.|:....|||||::.|:.|:|||.||:||||||||
Yeast   248 YECLTDLYDSISVTQAVIFCNTRRKVEELTTKLRNDKFTVSAIYSDLPQQERDTIMKEFRSGSSR 312

Human   326 VLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIET 390
            :||:||||||||||||||||||||||.|:||||||||||||||||||||||||.||...:|::|.
Yeast   313 ILISTDLLARGIDVQQVSLVINYDLPANKENYIHRIGRGGRFGRKGVAINFVTNEDVGAMRELEK 377

Human   391 FYNTTVEEMPMNVADLI 407
            ||:|.:||:|.::|.|:
Yeast   378 FYSTQIEELPSDIATLL 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF4A2	NP_001958.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		4/20 (20%)
		DEAD-like_helicase_N	21..407	CDD:475120	252/385 (65%)
		Q motif	33..61		18/27 (67%)
		DEAD box	183..186		2/2 (100%)
TIF1	NP_012985.3	DEAD-like_helicase_N	10..394	CDD:475120	252/385 (65%)