Protein Alignment EIF4A2 and Dbp80

DIOPT Version :10

• Sequence 1: NP_001958.2
• Gene: EIF4A2 / 1974
• HGNCID: 3284
• Length: 407
• Species: Homo sapiens
• Sequence 2: NP_001263168.1
• Gene: Dbp80 / 3354919
• FlyBaseID: FBgn0024804
• Length: 481
• Species: Drosophila melanogaster
• Alignment Length: 386
• Identity: 144/386 - (37%)
• Similarity: 226/386 - (58%)
• Gaps: 26/386 - (6%)

Human    19 DPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKG---YDVIAQAQSG 80
            :|:..:.|     |..|:.::||.|||:||||.||..||.||:.| :|.:..   .::|||:|||
  Fly    64 NPNSPLHS-----VKTFEALHLKASLLKGIYAMGFNTPSKIQETA-LPTLLADPPQNMIAQSQSG 122

Human    81 TGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVR-NE 144
            |||||.|.:::|.::.:.....|.|.|:||.|||.|..:|...:|.:    |........|| .|
  Fly   123 TGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQTGEVAARMGQF----CREIKLRFAVRGEE 183

Human   145 MQKLQAEAPHIVVGTPGRVFDM-LNRRYLSPKWIKMFVLDEADEML-SRGFKDQIYEIFQKLNTS 207
            :.:.:....||::||||::.|. :..|....|.|.:|||||||.|: ::|..||...|.:.||..
  Fly   184 VDRSKKIEEHILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVMIATQGHHDQCIRIHKMLNPH 248

Human   208 IQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLT 272
            .|::..|||...:|::..:..:.||..|.:.:||.:||.|||:|:..:.||.|.:.:.::|..::
  Fly   249 CQMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKCKNEEGKYNAIQNIYGCIS 313

Human   273 ITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGI 337
            :.||:||.:|:|...||..||.:...:|:.|.||:...:|..::..||||..:|||||::|:|||
  Fly   314 VGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGI 378

Human   338 DVQQVSLVINYDLPTNR------ENYIHRIGRGGRFGRKGVAINF----VTEEDKRILRDI 388
            |::||::|:|:|||.:.      |.|:|||||.|||....:..|.    |..|..:|.::|
  Fly   379 DIEQVTIVVNFDLPVDLDGMADCETYLHRIGRTGRFEPSALTRNSPIFGVKAESGKIGKEI 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF4A2	NP_001958.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		1/2 (50%)
		DEAD-like_helicase_N	21..407	CDD:475120	143/384 (37%)
		Q motif	33..61		15/27 (56%)
		DEAD box	183..186		2/2 (100%)
Dbp80	NP_001263168.1	DEADc_DDX19_DDX25	80..277	CDD:350721	76/201 (38%)
		SF2_C_DEAD	288..414	CDD:350174	52/125 (42%)