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Protein Alignment EIF4A2 and tif1

DIOPT Version :10

Sequence 1:	NP_001958.2	Gene:	EIF4A2 / 1974	HGNCID:	3284	Length:	407	Species:	Homo sapiens
Sequence 2:	NP_594854.1	Gene:	tif1 / 2542948	PomBaseID:	SPAC1006.07	Length:	392	Species:	Schizosaccharomyces pombe

Alignment Length:	387	Identity:	294/387 - (75%)
Similarity:	340/387 - (87%)	Gaps:	1/387 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    21 DGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTA 85
            |.|||:|::|::|.|||||||..|||||||||||:|||||||||:|.:...||:|||||||||||
pombe     7 DSVIETNYDEVIDTFDDMNLKPELLRGIYAYGFERPSAIQQRAIMPILGERDVLAQAQSGTGKTA 71

Human    86 TFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQA 150
            ||:||:||:::...|:.|||:||||||||||||||::||||.|...||||||||.||::|..|||
pombe    72 TFSISVLQKIDTSLKQCQALILAPTRELAQQIQKVVVALGDLMNVECHACIGGTLVRDDMAALQA 136

Human   151 EAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSA 215
             ..|:||||||||.||:.||.|....::||||||||||||||||||||:|||.|..:.|||||||
pombe   137 -GVHVVVGTPGRVHDMIQRRALPTDAVQMFVLDEADEMLSRGFKDQIYDIFQLLPPTAQVVLLSA 200

Human   216 TMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFL 280
            |||.||||||.|||||||||||||:|||||||||||:.||:||||||||||||||:|:||||||.
pombe   201 TMPQDVLEVTTKFMRDPIRILVKKDELTLEGIKQFYVAVEKEEWKLDTLCDLYETVTVTQAVIFC 265

Human   281 NTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLV 345
            |||||||||||::..||||||::||||||.:||.:|.|||:||||:|||||||||||||||||||
pombe   266 NTRRKVDWLTEQLTERDFTVSSMHGDMDQAQRDTLMHEFRTGSSRILITTDLLARGIDVQQVSLV 330

Human   346 INYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI 407
            ||||||.||||||||||||||||||||:|||||.:|.|::|:||.||||.:||||||:||||
pombe   331 INYDLPANRENYIHRIGRGGRFGRKGVSINFVTNDDVRMMREIEQFYNTHIEEMPMNIADLI 392

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.