DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EIF4A1 and CG7483

DIOPT Version :9

Sequence 1:	NP_001407.1	Gene:	EIF4A1 / 1973	HGNCID:	3282	Length:	406	Species:	Homo sapiens
Sequence 2:	NP_649788.2	Gene:	CG7483 / 40987	FlyBaseID:	FBgn0037573	Length:	399	Species:	Drosophila melanogaster

Alignment Length:	378	Identity:	270/378 - (71%)
Similarity:	318/378 - (84%)	Gaps:	1/378 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    29 EIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQ 93
            |::.:|:.|||.|.|||||||||||||||||||:|.|.:||.||||||||||||||||:|||||.
  Fly    23 EVIPTFNAMNLKEELLRGIYAYGFEKPSAIQQRSITPIVKGRDVIAQAQSGTGKTATFSISILQS 87

Human    94 IELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGT 158
            ::..|:.||.|.|:||||||.|||||::||||.|...||.||||||:..:::||.. ..||:.||
  Fly    88 LDTTLRETQVLCLSPTRELAVQIQKVILALGDMMNVQCHVCIGGTNLGEDIRKLDY-GQHIVSGT 151

Human   159 PGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEV 223
            |||||||:.||.|..:.|||.|||||||||::|||:||||:::.|...|||||:|||:|.::||:
  Fly   152 PGRVFDMIKRRVLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEM 216

Human   224 TKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWL 288
            |.|||.||||||||::|||||||:||::.|||||||.|||||||:||||||||||.||:||||||
  Fly   217 TSKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWL 281

Human   289 TEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNR 353
            ||||...:||||:|||||.|||||.||:|||:|.||||||||:.||||||||||||||||||.||
  Fly   282 TEKMREANFTVSSMHGDMPQKERDEIMKEFRAGQSRVLITTDVWARGIDVQQVSLVINYDLPNNR 346

Human   354 ENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 406
            |.|||||||.|||||||||||.|..:|.|.|||||.:|:|.|:|||:||||||
  Fly   347 ELYIHRIGRSGRFGRKGVAINFVKSDDIRILRDIEQYYSTQIDEMPMNVADLI 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EIF4A1	NP_001407.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PTZ00424	20..406	CDD:185609	268/376 (71%)
		Q motif	32..60		21/27 (78%)
		DEAD box	182..185		2/2 (100%)
CG7483	NP_649788.2	PTZ00424	4..399	CDD:185609	268/376 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53631
OrthoDB	1	1.010	-	-		D321438at33208
OrthoFinder	1	1.000	-	-		FOG0000304
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X250
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930