DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rev3l and DNApol-zeta

DIOPT Version :9

Sequence 1:XP_006512685.1 Gene:Rev3l / 19714 MGIID:1337131 Length:3123 Species:Mus musculus
Sequence 2:NP_524881.2 Gene:DNApol-zeta / 47186 FlyBaseID:FBgn0002891 Length:2130 Species:Drosophila melanogaster


Alignment Length:3190 Identity:891/3190 - (27%)
Similarity:1294/3190 - (40%) Gaps:1142/3190 - (35%)


- Green bases have known domain annotations that are detailed below.


Mouse     1 MFSVRIVTADYYMASPLPGLDTCQSPLTQLPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPY 65
            ::|||:|.||:||..|..|:|.|.|.|....:|:|||:||||....|||||:|:||:|||||:||
  Fly    11 VYSVRLVIADFYMEKPQFGMDPCYSELRGKEIKRVPVIRVFGGNSRGQKTCMHVHGVFPYLYIPY 75

Mouse    66 DGYG-QQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYN 129
            |... :..|..:.|||..:|:|:|::||..||.||||||:.||.|:||||||..|..|:|||::|
  Fly    76 DKKDFESLERGILQMAMHLDKAINISLGQGSSNAQHVFKIQLVKGIPFYGYHRVEHQFLKIYMFN 140

Mouse   130 PAMVKRICELLQSGAIMNKCYQPHEAHIPYLLQLFIDYNLYGMNLIN--LAAVKFRKARRKGNAS 192
            |..|:|...|||||||::|.:.|||:|:||:||..||||||||:.::  |..:|||:       :
  Fly   141 PRFVRRAANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVPLEVLKFRR-------N 198

Mouse   193 HATGLFKHQLSGNSPAGTLFRWEEDEIP------SSLL-LEGVEPLSTCELEVDAVAADILNRLD 250
            |                     ::|.||      :.|| :...:.::...||||..:..||||..
  Fly   199 H---------------------DDDVIPYANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQ 242

Mouse   251 IEAQIGG---NPGLQAIWEDEKQRRRNRNESSQISQPESQDCRFVPATESEKQFQKRLQEVLKQN 312
            :.|:...   |||::|||.|||.||:...| ......:.:....||..|.... |:|.|..:.::
  Fly   243 LVAKSKSNHTNPGIEAIWNDEKLRRQKLVE-KHTDAGDEEKAEAVPVLELPPT-QERHQIEIAES 305

Mouse   313 DFSVRTLSGSVDYSNGSQEFSAELTLHSEILSPEMLPCSPANMIEVHKDTDLSKGNTKHKVEEAL 377
            |...||                  .|.|::::                            :|::.
  Fly   306 DIFYRT------------------ALESKLMT----------------------------LEQST 324

Mouse   378 INEEAILNLIENSQTFQPLTQRLSETPVFMGSSPDESLVHLLAGLESDGYQGEKNRMPLPCHSFG 442
            ::|:.:     :.||..|.....:..|                     |.:.:|.|..|. ....
  Fly   325 LSEQTL-----SDQTILPQATMQTTMP---------------------GTKAQKRRFNLQ-KLLA 362

Mouse   443 ESQNPQNSDDEENEPQIEKEEMELSVVMSQRWDSDIEEH--CAKKRSLCRNAHRSSTEEDDSSSE 505
            .:..|:....::.:..:..              |.|:.|  |....|:     ..||.:|:|...
  Fly   363 NAVYPEECSQDQQQLLVNA--------------SFIQNHVTCGYSSSV-----SLSTSKDESDDL 408

Mouse   506 EEMEWTDNSLLFANLSIPQLDGTADENSDNPLNNENSRAHSSVIATSKLSVRPSIFHKDAATLEP 570
            :|.. .|..|:   ||:.|..|..              .|.:.:....|.:      .||..|  
  Fly   409 DETV-VDEELI---LSLTQPHGAI--------------PHDATLREEDLEL------LDALQL-- 447

Mouse   571 PSSAKITFQCKHTSALSSHVLNKDGLTEDLSQPNSTEKGRDNSVTFTKESTYSMKYSGSLSSTVH 635
                                         |.:.|.:|...|                  |.|::.
  Fly   448 -----------------------------LEEQNESESHVD------------------LDSSLA 465

Mouse   636 SDNSHK------EICKKDKSLPVSSCESSVFDYEEDIPSVTRQVPSRKYSNMRKIEKDASCIHVN 694
            ..:.||      |:..|:     ::..:::||  ||:.|                ::||.  ...
  Fly   466 PLSQHKKFELTPELLDKE-----TAATAALFD--EDVDS----------------DEDAD--QET 505

Mouse   695 RHISETILGKNSFNFADLNHSKRKLSSEGNEKGNSTSLSGVFPSSLTENCDLLPSSGENRSMAHS 759
            ||...|:|.       |::....||:.....:......|...|..         ...::|.....
  Fly   506 RHDFSTVLD-------DVDELLLKLTQSQPAESKELKASSKLPQI---------DGADDRLQRTP 554

Mouse   760 LESITDESGLNKLKIRYEEFQEHKMEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQSG 824
            ::||:.:|..:..|.......:..:.|                            ||.|.|..:.
  Fly   555 IKSISSKSKSSPSKTPTTPIGQKSLPK----------------------------SPRTPKTSAA 591

Mouse   825 NKPSRLKLNKKKLIGLQETSTKSTETGATKDSCTHNDLYTGASEKENGLSSDSAKATHGTFENKP 889
            .|.:.|.|.                                       :.|.|:|.::..|..:|
  Fly   592 KKYAPLALT---------------------------------------IGSSSSKKSNDEFAGRP 617

Mouse   890 PTEHF---IDCHFGDGSLEAEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTQNSKISLPHPMEI 951
            .....   :|...|.|:|..|.|.   ..|..:...|:.::|    :|..:.:|....:......
  Fly   618 SNPRLSLQLDQGTGTGTLRPEISL---RKKLAMSEMRRKSFE----DSFVLLKNDCTPVRSTRRS 675

Mouse   952 GENLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKK 1016
            ..|||.|                   :||.:.....:|.    |..|..|     ||:..:|..|
  Fly   676 TSNLDKT-------------------HIICSLTPRDRNP----GLSDMFE-----TEDGKQLPPK 712

Mouse  1017 LAPLKDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKS-------AKKKPGKQHRTNSENIKRTL 1074
            ....|..|       :|:.......||.....:..|:|       .|.:...:|:.||.|     
  Fly   713 KVVRKTRW-------STRNQDIESLPKAGCEIERPHRSEGSALDELKPRRSARHKVNSAN----- 765

Mouse  1075 SFRKKRTHAVLSPPSPSYIAETEDCDLSYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEI 1139
                                                              |..|       :.||
  Fly   766 --------------------------------------------------PDEC-------SSEI 773

Mouse  1140 MAAAEKESMLFKGPNVYNTKTVSPRVGKASRARAQVKKSKARLANSSVVTNKRNKRNQTTKLVDD 1204
                               :|..|||                                ||..:|.
  Fly   774 -------------------QTTGPRV--------------------------------TTTSLDR 787

Mouse  1205 GKKKPRAKQKQRANEKSLSRKHAIPADEKMKPHSEAELTPNHQSVSELTSSSGAQALSKQKEMSQ 1269
            .:||.|..|..:.|.|                                ||.:|..||.|..:.|.
  Fly   788 PQKKARLSQSPKENTK--------------------------------TSMNGTVALEKATKDSS 820

Mouse  1270 TGPAVDHPLPPAQPTGISAQQRLSNCFSSFLESKKSVDLRTFPSSRDDSHSSVVYSSIGPGISKI 1334
            :.....|    .|...:|.|       ..:||||                               
  Fly   821 SNSESPH----QQENSVSEQ-------IEYLESK------------------------------- 843

Mouse  1335 NIQRSHNQSAMFTRKETTLIQKSIFDLSNHLSQVAQSTQVCSGIISPKTEESSSTQKNCGSSMGK 1399
                                                          ||  :|..|.::|...:  
  Fly   844 ----------------------------------------------PK--KSDETARSCDEKL-- 858

Mouse  1400 LNEYRSSLESKPEQVCAPNFLHCKDSQQQTVSVSEQSKTSETCSPGNAASEESQTPNCF-VTSL- 1462
               .|..:..:|..: :|.     ||...|..:        |.||.:..:.||.|.:.: ||.| 
  Fly   859 ---QRELIPQEPAGI-SPG-----DSANSTEEI--------TFSPCHDEAIESDTESDYIVTKLR 906

Mouse  1463 KSP-IKQIAWEQKQRGFILDMSNFKPEKVKQRSLSEAISQTKALSQCKNQNVSTPSVFGEGQSGL 1526
            |:| :|::.|                                                       
  Fly   907 KTPNLKRLRW------------------------------------------------------- 916

Mouse  1527 AVLKELLQKRQQKAQSTNVVQDSTSTHQPDKNISVSNEHKKANKRTRPVTSPRKPRTPRRTKPKE 1591
            ::..|||                                   ||:..|.:..|.|.|       |
  Fly   917 SIRSELL-----------------------------------NKQFTPSSGIRPPET-------E 939

Mouse  1592 QTPRRLKVDPLNLQTSGHLDNSLSDDSPILFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFC 1656
            .||:                                         |||:.|   :.||       
  Fly   940 TTPQ-----------------------------------------LSPKSN---ESNT------- 953

Mouse  1657 SFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIDKSELLSHDRQSCSEEKHHVSDSSPWIRASTL 1721
                                                                             
  Fly   954 ----------------------------------------------------------------- 953

Mouse  1722 NPELFEKVAMDNNENHRHSQWKNSF--HPLTSHSNSIMESFCVQQAENCLTEKSRLNRSSVSKEV 1784
             |||.                 .||  |.|..:|.|:...|.                  .|.|:
  Fly   954 -PELM-----------------RSFYEHSLIVNSPSVFSDFL------------------DSPEI 982

Mouse  1785 FLSLPQANSSDWIQGHNRKEADQSLHSANTSFTTILSSPDGELVDAASEDLELYVSRNNDVLTPT 1849
            .:..|:                              |:|                        |:
  Fly   983 HMDSPR------------------------------SAP------------------------PS 993

Mouse  1850 PDSSPRSTSSPLQSKNGSFTPRTAHILKPLMSPPSREEIVATLLDHDLSEAIYQEPFCSNPSDVP 1914
            |||:             ||      ::.||..|||.:|:|:.....|:.|..:|:|:.|||||| 
  Fly   994 PDSN-------------SF------VIAPLELPPSYDEVVSGSRKMDIPEYEFQKPYYSNPSDV- 1038

Mouse  1915 EKPREIGGRLLMVETRLPNDLIEFEGDFSLE-GLRLWK------TAFSAMTQNPRPGSPLRNGQA 1972
            .|..|:|..:|.:.....||...|:.....: ||..|:      ....||.|..|       |:.
  Fly  1039 SKVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRHR-------GEQ 1096

Mouse  1973 VVNKESSNSHKMVEDKKIVIMPCKYAPSRQLVQAWLQAKEEYERSKKLPKTELTPVTKSAENVSP 2037
            .|.:..|.      .::|.|.|.:.||:.|..:.||:|| |..|.::.||       ||::::..
  Fly  1097 KVREYFST------QQRIAIEPAQLAPTWQEAKIWLKAK-ELLRQREEPK-------KSSDDIDS 1147

Mouse  2038 SLNPGDTCAVSPQVDKCPHTLSSSAHTKEEVSKSQIALQTSTTGCSQTLLAAASAAVPEEDEDDN 2102
            .:                           ::.:.:|.:..                  :.:|.|.
  Fly  1148 PI---------------------------KIKRQKITMML------------------QAEEGDG 1167

Mouse  2103 DNCYVSYSSPDSPGIPPWQQAASPDFRSLNGDDRHSSPGKEL-CSLAVENFLKPIKDGIQKSSCS 2166
            .                            :||:   ..|:|| |||:    |.|:...  |..|.
  Fly  1168 G----------------------------SGDE---DAGEELDCSLS----LTPLSQA--KDKCK 1195

Mouse  2167 ESWEPQVISPIHARAR-TGKWDPLCLHSTPVMQRKFLEKLPEATGLSPLSVE----PKTQKLYNK 2226
                   .:|..::|| |||                 .:|...|.||.:..:    |.:|.....
  Fly  1196 -------ATPTSSKARETGK-----------------SRLKRGTRLSFIGSQDEEPPSSQSSEQS 1236

Mouse  2227 KGSDADGLRRVLLTTQVENQFAAVNTPKKETSQ---------IDGPSLNNTYGFKVSIQNLQEAK 2282
            ..|.|         .|.|...::.....:.:||         :...:|:||:||||:::|||:||
  Fly  1237 VSSSA---------AQAELDRSSFLRQLEGSSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAK 1292

Mouse  2283 ALHEIQNLTLISVELHARTRRDLQPDPEFDPICALFYCISSDTPLPDTEK--TELTGVIVIDKDK 2345
            |..:..:||:|::|:...||.||||||..|.|..|||.|  :..||| ||  ::..|.|:::   
  Fly  1293 ADIDCNHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAI--EHSLPD-EKLPSKACGYIMVN--- 1351

Mouse  2346 TVTHQDIRSQTPLLIRSGI-TGLEVTYAADEKALFQEITNIIKRYDPDILLGYEIQMHSWGYLLQ 2409
              |.||:.|:.|.   .|| ..:||.....|...|:.:..:.:|:|.||..||||:|.||||::.
  Fly  1352 --TVQDLLSEGPF---HGIDRDIEVQVVTSEAEAFEALLALCERWDADIYAGYEIEMSSWGYVID 1411

Mouse  2410 RAAALSVDLCQMISRVPDDKIENRFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVALTNYTF 2474
            ||..|..::..::||||..|:.:....:|:.: :|...|:.:.|||.|::||:||:|:|||:|||
  Fly  1412 RAKHLCFNIAPLLSRVPTQKVRDFVDEDREQF-TDLDVEMKLCGRILLDVWRLMRSEIALTSYTF 1475

Mouse  2475 ENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARL 2539
            |||.:|:||:|.|..|.:.|::||.:...  ||.::::|:.||||.|.:|:||||:|:|||||:|
  Fly  1476 ENVMYHILHKRCPWHTAKSLTEWFGSPCT--RWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKL 1538

Mouse  2540 FGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSIQQRSQMRAPQCVPLIMEPESRFYSNSVL 2604
            .||||..||:||||:||||||||||||.|.:|::||:|.|:.||||:.:.|||||:||||::.::
  Fly  1539 IGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYADPLI 1603

Mouse  2605 VLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQ-IRHD-VTVSPNGV 2667
            ||||||||||::||||||||||||.||:||....|:||.:.|||...:|.: :.|| |||||.||
  Fly  1604 VLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGV 1668

Mouse  2668 AFVKPSVRKGVLPRMLEEILKTRLMVKQSMKSYKQDRALSRMLNARQLGLKLIANVTFGYTAANF 2732
            .|||..||:|:|||||.|||.||.|||||||.:|...||.|:|::|||||||:||||:|||||||
  Fly  1669 VFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANF 1733

Mouse  2733 SGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEI 2797
            |||||.:|||||:|.|.|||||||||||.:.::|..|||||||||||||:.|..:.::|:||:||
  Fly  1734 SGRMPSVEVGDSVVSKGRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEI 1798

Mouse  2798 AEAVTATNPRPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKEPVFDAKGIETVRRDSCPAVSKI 2862
            |:|||..||:|||||.||||.||:||||||||||||||.||::||::||||||||||.||||:|:
  Fly  1799 AKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKM 1863

Mouse  2863 LERSLKLLFETRDISLIKQYVQRQCMKLVEGKASIQDFIFAKEYRGSFSYRPGACVPALELTRKM 2927
            ||:.|::||||:|:|.||.||.||..||:.|:|::||.|||||:||...|:|.|||||||||||.
  Fly  1864 LEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEFRGLNGYKPTACVPALELTRKW 1928

Mouse  2928 LAYDRRSEPRVGERVPYVIIYGTPGLPLIQLIRRPAEVLQDPTLRLNATYYITKQILPPLARIFS 2992
            :..|.|..||.|||||::|:.|.||:.||:|:|.|.::|.:...::||.|||||.|:|||.|...
  Fly  1929 MQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNRCLL 1993

Mouse  2993 LIGIDVFSWYQELPR--IQKATSSSRSELEGRKG---TISQYFTTLHCPV-CDDLTQHGICSKCR 3051
            |||.:|..|:..|||  :......:.:||.|.:|   ||||||:|..|.: |...|:.|||..|.
  Fly  1994 LIGANVHDWFASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTSCVIDCGRQTKAGICPDCL 2058

Mouse  3052 SQPQHVAIILNQEIRELERKQEQLIKICRNCTGSFDRHIPCVSLNCPVLFKLSRVNRELSKAPYL 3116
            .......::|:.:...|||..:...:||:.|.|... .:.|.||:||||:.|....|||.:..:.
  Fly  2059 KNATTCVVVLSDKTARLERGYQLTRQICQACCGRLG-SLQCDSLDCPVLYVLEGKRRELQQIEHW 2122

Mouse  3117 RQLLD 3121
            .:||:
  Fly  2123 NKLLE 2127

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rev3lXP_006512685.1 PTZ00166 6..>195 CDD:240301 99/191 (52%)
DUF4683 747..1133 CDD:374062 57/395 (14%)
DNA_polB_zeta_exo 2287..2525 CDD:99821 95/240 (40%)
POLBc_zeta 2551..2999 CDD:99917 290/449 (65%)
zf-C4pol 3035..3102 CDD:372984 22/67 (33%)
DNApol-zetaNP_524881.2 PTZ00166 20..>196 CDD:240301 94/175 (54%)
DNA_polB_zeta_exo 1297..1518 CDD:99821 92/234 (39%)
POLBc_zeta 1550..2000 CDD:99917 290/449 (65%)
zf-C4pol 2041..2107 CDD:405022 21/66 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 589 1.000 Domainoid score I204
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1190 1.000 Inparanoid score I192
Isobase 1 0.950 - 0 Normalized mean entropy S3397
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D20210at2759
OrthoFinder 1 1.000 - - FOG0001033
OrthoInspector 1 1.000 - - oto93882
orthoMCL 1 0.900 - - OOG6_102751
Panther 1 1.100 - - LDO PTHR45812
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R348
SonicParanoid 1 1.000 - - X3116
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.810

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