Protein Alignment UBR1 and UBR1

DIOPT Version :10

• Sequence 1: NP_777576.1
• Gene: UBR1 / 197131
• HGNCID: 16808
• Length: 1749
• Species: Homo sapiens
• Sequence 2: NP_011700.1
• Gene: UBR1 / 853096
• SGDID: S000003416
• Length: 1950
• Species: Saccharomyces cerevisiae
• Alignment Length: 2078
• Identity: 412/2078 - (19%)
• Similarity: 741/2078 - (35%)
• Gaps: 627/2078 - (30%)

Human     7 GGTERMEISAELPQTPQRLASWWDQQVDFYTAF-LHHLAQLVPEIYFAE-----MDPDL----EK 61
            |.|||.::|..|.:...|           |..| :.:..:.:|.::.|.     .:|:|    :.
Yeast    33 GPTERADMSRALKEFIYR-----------YLYFVISNSGENLPTLFNAHPKQKLSNPELTVFPDS 86

Human    62 QEESVQMSIFTPLEWYLFGE-DPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCM 125
            .|::|.:...|..:...|.: |.....:..||:|  :.|||.||.||..|.|.:|..|.|||||:
Yeast    87 LEDAVDIDKITSQQTIPFYKIDESRIGDVHKHTG--RNCGRKFKIGEPLYRCHECGCDDTCVLCI 149

Human   126 DCFQDSVHKNHRYKMHTSTG------GGFCDCGDTEAWKTGPFC--------VNHEPGRAGTIKE 176
            .||....|.||    |..|.      .|.|||||.|||.:...|        ::.:|.....|||
Yeast   150 HCFNPKDHVNH----HVCTDICTEFTSGICDCGDEEAWNSPLHCKAEEQENDISEDPATNADIKE 210

Human   177 NSRCPLNEEV-IVQARKIFPSVIKYVVEMTIWEEEKELPPELQ------IREKN----------- 223
            ..  ..|:.| |.....:...|..|.::  ::.:..|..|.:|      :||..
Yeast   211 ED--VWNDSVNIALVELVLAEVFDYFID--VFNQNIEPLPTIQKDITIKLREMTQQGKMYERAQF 271

Human   224 -------------------------------------ERYYCVLFNDEHHSYDHVIYSLQRALDC 251
                                                 |.|..:::|||:|:|.....:|::.:.
Yeast   272 LNDLKYENDYMFDGTTTAKTSPSNSPEASPSLAKIDPENYTVIIYNDEYHNYSQATTALRQGVP- 335

Human   252 ELAEAQLHTTAIDKEGRRAVKA--------GAYAACQE--AKEDIKSHSENVSQHPLHVEVL--- 303
            :.....|.|:.||.|||..:|.        |.:.|.|.  ....:.|.||.:.|......:|
Yeast   336 DNVHIDLLTSRIDGEGRAMLKCSQDLSSVLGGFFAVQTNGLSATLTSWSEYLHQETCKYIILWIT 400

Human   304 HSEIMAHQKFALRLGSWMNKIMSYSSDF-------------RQIFCQACLREEP----------- 344
            |...:.:..|.....:.|.|.:  .|::             .:.|.....:.:|
Yeast   401 HCLNIPNSSFQTTFRNMMGKTL--CSEYLNATECRDMTPVVEKYFSNKFDKNDPYRYIDLSILAD 463

Human   345 -------------------------DSENP-------CLISRLMLWDAKLYKGARKILHELIFSS 377
                                     |.|.|       ..:..::.:|.:.:|..||.:..:|..:
Yeast   464 GNQIPLGHHKILPESSTHSLSPLINDVETPTSRTYSNTRLQHILYFDNRYWKRLRKDIQNVIIPT 528

Human   378 FFMEMEYKKLFAMEFVKYYKQLQKE--YISDDHDRSISITALS---VQMFTVPTLARHLIEEQNV 437
            ......||.:|..:.|:.:..:.:.  |:    ||...:||:.   ||:||.||.|:::.|.|:.
Yeast   529 LASSNLYKPIFCQQVVEIFNHITRSVAYM----DREPQLTAIRECVVQLFTCPTNAKNIFENQSF 589

Human   438 ISVITETLLEVLPEYL---------DRNNKFNF-QGYSQDKLGRVYAVICDLKYILISK---PTI 489
            :.::. :::::..|:.         .|..|.|. :.||......:|.|     ..|:||   |.|
Yeast   590 LDIVW-SIIDIFKEFCKVEGGVLIWQRVQKSNLTKSYSISFKQGLYTV-----ETLLSKVHDPNI 648

Human   490 WTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHI-EVDPDWEAAIAIQMQLKNILLMFQEWC 553
               .||.:.:   .|.|.:.....|..:|:|:.|:|: ..|.::.:.:.....:.:|:...::..
Yeast   649 ---PLRPKEI---ISLLTLCKLFNGAWKIKRKEGEHVLHEDQNFISYLEYTTSIYSIIQTAEKVS 707

Human   554 -----ACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQSCGHSLETKSYRVSEDLVSIHLPLSR 613
                 :.|.:|.|.|        :|..:||:.:.....:....|.|...:.||.:.|:...||..
Yeast   708 EKSKDSIDSKLFLNA--------IRIISSFLGNRSLTYKLIYDSHEVIKFSVSHERVAFMNPLQT 764

Human   614 TLAGLHVRLSRLGAVSRLH---EFVSFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQV 675
            .|:.|..::|...|...|.   :|:...||.        ||.:||.:|:....|.|||:|::.|.
Yeast   765 MLSFLIEKVSLKDAYEALEDCSDFLKISDFS--------LRSVVLCSQIDVGFWVRNGMSVLHQA 821

Human   676 FYYQDVKCREEM--YDKDIIMLQIGASLM---DPNKFLLLVLQRYELAEAFNKTISTKDQDLIKQ 735
            .||   |...|:  |.:||.:.|: |.|.   |..:.:..:|.|:||.:.|...:..:......:
Yeast   822 SYY---KNNPELGSYSRDIHLNQL-AILWERDDIPRIIYNILDRWELLDWFTGEVDYQHTVYEDK 882

Human   736 YNTLIEEMLQVLIYIVGER-YVPGVGNVTKEEVTM--REIIHLLCIEPMPHSAIAKNLPEN-ENN 796
            .:.:|::.:..:..|:.|| |.....::....:..  ..||:.|.::|:.:|.:.:::|:. ..:
Yeast   883 ISFIIQQFIAFIYQILTERQYFKTFSSLKDRRMDQIKNSIIYNLYMKPLSYSKLLRSVPDYLTED 947

Human   797 ETGLENVINKVATFKKP-GVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQK--------- 851
            .|..:..:.:|:.|.:| |::.:||::|| .||         |:|....|..:::.
Yeast   948 TTEFDEALEEVSVFVEPKGLADNGVFKLK-ASL---------YAKVDPLKLLNLENEFESSATII 1002

Human   852 KRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIM---MYILRTVFERAI--------DTDSNL 905
            |....::|||.......|:..      |..|:.|.:   .:...|||.:.:        |.:.:.
Yeast  1003 KSHLAKDKDEIAKVVLIPQVS------IKQLDKDALNLGAFTRNTVFAKVVYKLLQVCLDMEDST 1061

Human   906 WTEGMLQMAFHILALG-LLEEKQQLQKA----PEEEVTFDFYHKASRLGSSAM--NIQMLLEKLK 963
            :...:|.:...|.... |:..|..:.:|    |...:.....:..|.:.|.::  ....||||:
Yeast  1062 FLNELLHLVHGIFRDDELINGKDSIPEAYLSKPICNLLLSIANAKSDVFSESIVRKADYLLEKM- 1125

Human   964 GIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEK----------AE 1018
                                .:|:..|....::|      |..|..:...|:|          .|
Yeast  1126 --------------------IMKKPNELFESLIA------SFGNQYVNDYKDKKLRQGVNLQETE 1164

Human  1019 RKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRIALG 1083
            ::||...|:.|:.:::|:.:..|..|::.|:..:|   |.....|.:
Yeast  1165 KERKRRLAKKHQARLLAKFNNQQTKFMKEHESEFD---EQDNDVDMV------------------ 1208

Human  1084 PKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQHRGKPIELSGEALDP----- 1143
               |..|.|.|..||.|||:..    ..:..|:.|         .|...||...|...:|
Yeast  1209 ---GEKVYESEDFTCALCQDSS----STDFFVIPA---------YHDHSPIFRPGNIFNPNEFMP 1257

Human  1144 ------------LFMDPDLAYG-TYTGSCG---------HVMHAVCWQKYFEAVQLSSQQRIHVD 1186
                        .::|.|:... ...||||         |.:|..|:::|.:..:.|
Yeast  1258 MWDGFYNDDEKQAYIDDDVLEALKENGSCGSRKVFVSCNHHIHHNCFKRYVQKKRFS-------- 1314

Human  1187 LFDLESGEYLCPLCKSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHA 1251
                 |..::||||::..|..:|:  .|..|.|:.        |:|..::::.|:.
Yeast  1315 -----SNAFICPLCQTFSNCTLPL--CQTSKANTG--------LSLDMFLESELSL--------- 1355

Human  1252 KGENPIPIFFNQGMGDSTLEFHSILSF------GVESSI-KYSN-SIKEMVILFATTIYRIGLKV 1308
               :.:...|.....::....:||.|.      |.:.:: |.:| |.|::.::.:
Yeast  1356 ---DTLSRLFKPFTEENYRTINSIFSLMISQCQGFDKAVRKRANFSHKDVSLILS---------- 1407

Human  1309 PPDERDPRVPMLTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVL 1373
                       :.|   |.||..:|                             :|.|:..|..:
Yeast  1408 -----------VHW---ANTISMLE-----------------------------IASRLEKPYSI 1429

Human  1374 I------QKHLVRLLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSS 1432
            .      ||:      ..|.||       |:.|.||..::|.    ||:.: :|...||.:|.:.
Yeast  1430 SFFRSREQKY------KTLKNI-------LVCIMLFTFVIGK----PSMEF-EPYPQQPDTVWNQ 1476

Human  1433 YNHLY-------LFHLITMAHMLQILLTVDTGLPLAQVQEDSEEAHSASSFFAEISQ-------- 1482
             |.|:       ||..:::...:...||..:...|....:...:|...:..:|:.|:
Yeast  1477 -NQLFQYIVRSALFSPVSLRQTVTEALTTFSRQFLRDFLQGLSDAEQVTKLYAKASKIGDVLKVS 1540

Human  1483 -----------------YTSGSIGCDIPGWYLWVSLKNGITPYLRCAALF---FHYLLGVTPPEE 1527
                             ..|.||..|:...:|..||    .|.:|...:|   .|.|:..:..|.
Yeast  1541 EQMLFALRTISDVRMEGLDSESIIYDLAYTFLLKSL----LPTIRRCLVFIKVLHELVKDSENET 1601

Human  1528 LHTNSAEGEYSALCSYLSLPTNLFLLFQEYWDTVRPLLQRWCADPALLNCLKQKNTVVRYPRKRN 1592
            |..|..|.|..             |.|::..:.|...|:......:|::.|..:.::|.:|...|
Yeast  1602 LVINGHEVEEE-------------LEFEDTAEFVNKALKMITEKESLVDLLTTQESIVSHPYLEN 1653

Human  1593 ---------SLIELPDDYSCLLNQASHFRCPRSAD------DERKHPVLCLFCGAIL-------- 1634
                     .||:|....:..:.|:...:......      |.|....:||.||..:
Yeast  1654 IPYEYCGIIKLIDLSKYLNTYVTQSKEIKLREERSQHMKNADNRLDFKICLTCGVKVHLRADRHE 1718

Human  1635 --------CSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPY 1691
                    |.:......:.|..|              ||:.|......:.:          .|||
Yeast  1719 MTKHLNKNCFKPFGAFLMPNSSE--------------VCLHLTQPPSNIFI----------SAPY 1759

Human  1692 LDEYGETD-PGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQE--------TNQMLFGFN 1745
            |:.:||.. ..::||:...|:.:||..|:.:|..:.|...|:|...        :|..||.||
Yeast  1760 LNSHGEVGRNAMRRGDLTTLNLKRYEHLNRLWINNEIPGYISRVMGDEFRVTILSNGFLFAFN 1822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBR1	NP_777576.1	UBR-box_UBR1	98..168	CDD:439076	33/83 (40%)
		ClpS	221..301	CDD:460621	24/137 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	842..868		5/34 (15%)
		UBC2-binding region (U2BR). /evidence=ECO:0000250|UniProtKB:P19812	1019..1054		8/34 (24%)
		RING-H2_UBR1	1094..1212	CDD:438346	31/144 (22%)
		PRT6_C	1297..1724	CDD:465944	89/499 (18%)
UBR1	NP_011700.1	UBR-box_UBR1_like	123..190	CDD:439070	33/80 (41%)
		ClpS	308..>358	CDD:469998	10/65 (15%)
		RING-H2_UBR1-like	1286..1332	CDD:438145	9/53 (17%)
		PRT6_C	1402..1793	CDD:465944	88/445 (20%)