DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and htl

DIOPT Version :9

Sequence 1:	NP_033076.2	Gene:	Ret / 19713	MGIID:	97902	Length:	1115	Species:	Mus musculus
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	363	Identity:	156/363 - (42%)
Similarity:	213/363 - (58%)	Gaps:	30/363 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse   694 RRPSLDSTENQVPVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAV 758
            |...|.:.....|.:.::.|.|..||.||.:||||.|||||.||:||.|       ......|||
  Fly   385 RTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMA-------EVNNAIVAV 442

Mouse   759 KMLKENASQSELRDLLSEFNLLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRK 822
            ||:||..:..::..|:.|..::|.: .|.::|.|.|.|||:|||.:|||||.:|:|:.||..:|.
  Fly   443 KMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRP 507

Mouse   823 IGPAYVSGGGSRNSSS-LDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEG 886
            .|     ....|:||. ...|...|:|..|||.||.||:|||.|||..:.:||||||||:||::.
  Fly   508 FG-----RDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDD 567

Mouse   887 RKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGN 951
            ..:||:||||:||:...|.|.|.:.||:|:||||.|||.:..|.::|||||:|:|||||:|.|..
  Fly   568 YVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQ 632

Mouse   952 PYPGI-PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRD 1015
            |||.| ..|.|:..|.:|.|||:|..||..:|.||.|||....|.||.|.:|.:.::|::....|
  Fly   633 PYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKED 697

Mouse  1016 YLDLAAS---TPSDSLLYDDGLSEEETPLVD-----CN 1045
            |||:..:   ||..:       |:||....|     ||
  Fly   698 YLDVDIANLDTPPST-------SDEEEDETDNLQKWCN 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_033076.2	Cadherin	173..262	CDD:278457
		PTKc_RET	724..1013	CDD:173631	135/291 (46%)
		Pkinase_Tyr	725..1006	CDD:285015	134/283 (47%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	141/299 (47%)
		STYKc	416..688	CDD:214568	134/283 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810