DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Reln and CG17739

DIOPT Version :9

Sequence 1:	NP_035391.2	Gene:	Reln / 19699	MGIID:	103022	Length:	3461	Species:	Mus musculus
Sequence 2:	NP_610757.1	Gene:	CG17739 / 36333	FlyBaseID:	FBgn0033710	Length:	873	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	108/539 - (20%)
Similarity:	166/539 - (30%)	Gaps:	194/539 - (35%)

- Green bases have known domain annotations that are detailed below.

Mouse    60 LHIAGNPTYYVPGQEYHVTISTSTFFDGLLVTGLYTSTSIQSSQSIGGSSAFG---FGIMSDHQF 121
            |.:.||...|||||.|:|::|.   |.||.......:..::|....|.::|.|   ...:::.:|
  Fly    43 LSVNGNTQSYVPGQRYNVSLSA---FSGLSFISFMLALDLESGDGDGDANALGTWEIADLAETRF 104

Mouse   122 GNQFMCSVVASHVSHLPTTNLSFVWIAPPA-GTGCVNFMATATHRGQVIFKD--ALAQQLCEQGA 183
            ..:  |..:..:.:....|.:...|:||.: |.||:...||......|.|.|  .|.:::||:
  Fly   105 SPR--CPNLVENTNTNVKTRVDVFWVAPSSPGQGCILLRATVMQHRDVWFMDDGFLTKRMCEE-- 165

Mouse   184 PTEATAYSHLAEIHSDSVILRDDFDSYQQLELNPNIWVECSNCEMGE------------------ 230
                       |:        ||.|:      .|:|...|..|:..:
  Fly   166 -----------EV--------DDIDT------QPSIVDPCCACDEAKYELTFEGKWSRHTHPKDF 205

Mouse   231 ------------------------QCGTIM---------HGNAVTF-CEPYGPRELTTTCL---- 257
                                    |.|.:.         ||:..|. .|.....|...|.:
  Fly   206 PANSWRTRFSDIIGASHTLDYRFWQYGELASEGLREVAEHGSTRTLESELKDQSEHIRTIIKARG 270

Mouse   258 ----NTTTASVLQFSIGSGS---CRFSYSDPSITVSYAKNNTADWI----QLEKIRAP--SNVST 309
                |.|..:...|.:.|..   ...|..|||          .|||    .|| :..|  |.|..
  Fly   271 IAYPNVTGKTFAVFRVDSNHHLISLVSMVDPS----------PDWIVGVSGLE-LCLPNCSWVEN 324

Mouse   310 VIHILYLPEEAKGESVQFQWKQDSLRV-----------------GEVYEACWALDNILVINSAHR 357
            .:|.|| |.:|..:|.......|..:|                 ...|:...|....|.....:|
  Fly   325 KVHNLY-PWDAGTDSGPSYMSADQPQVPPDVVRRIKSNFPNDPRSPFYDPTGAQMKPLATLHINR 388

Mouse   358 EVVLEDNLDPVD---------TGNWLFFPGATVK--------------------HSC----QSDG 389
            ..:.|.|.:..|         |.:|..:...|.|                    |.|    :.:.
  Fly   389 RRLYEKNCESSDSEQVPPECATNSWSRWDECTTKCGPGKQYRIREFKNPALASRHRCNNALREEK 453

Mouse   390 NSIYFHGNEGSEFNFATTRDVDL-------STEDIQ---EQWSEEFESQPTGWDILGAVVGADCG 444
            |.:   |::.:.||..|....:.       |::|.|   ..|||        |    :.....||
  Fly   454 NCV---GHKCAGFNEETAEGGEPEVAPSPGSSDDPQCGLSDWSE--------W----SSCTVTCG 503

Mouse   445 TVESGLSLVFLKDGERKLC 463
            |.|...|..:|....:|.|
  Fly   504 TGEMTRSRHYLNKKAKKKC 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reln	NP_035391.2	Reeler	49..179	CDD:260081	33/124 (27%)
		Reelin_subrepeat_Nt	203..352	CDD:197344	42/234 (18%)
		Reelin_subrepeat_like	422..557	CDD:197448	11/42 (26%)
		Reelin_repeat_1_subrepeat_1	527..672	CDD:197345
		BNR 1	593..604
		Reelin_repeat_1_subrepeat_2	709..863	CDD:197353
		BNR 2	799..810
		Reelin_repeat_2_subrepeat_1	868..1035	CDD:197346
		BNR 3	952..963
		EGF_2	1032..1060	CDD:285248
		Reelin_repeat_2_subrepeat_2	1066..1221	CDD:197354
		BNR 4	1157..1168
		Reelin_repeat_3_subrepeat_1	1241..1410	CDD:197347
		BNR 5	1323..1334
		Reelin_repeat_3_subrepeat_2	1448..1598	CDD:197355
		BNR 6	1535..1546
		Reelin_repeat_4_subrepeat_1	1606..1775	CDD:197348
		BNR 7	1686..1697
		EGF_2	<1773..1795	CDD:285248
		Reelin_repeat_4_subrepeat_2	1801..1938	CDD:197356
		BNR 8	1884..1895
		Reelin_repeat_5_subrepeat_1	1960..2131	CDD:197349
		BNR 9	2043..2054
		EGF_2	2131..2160	CDD:285248
		Reelin_repeat_5_subrepeat_2	2166..2315	CDD:197357
		BNR 10	2250..2261
		Reelin_repeat_6_subrepeat_1	2323..2479	CDD:197350
		BNR 11	2399..2410
		Reelin_repeat_6_subrepeat_2	2515..2662	CDD:197358
		BNR 12	2598..2609
		Reelin_repeat_7_subrepeat_1	2670..2854	CDD:197351
		BNR 13	2778..2789
		EGF_2	2859..2883	CDD:285248
		Reelin_repeat_7_subrepeat_2	2890..3051	CDD:197359
		BNR 14	2979..2990
		Reelin_repeat_8_subrepeat_1	3056..3230	CDD:197352
		BNR 15	3143..3155
		EGF_2	3235..3259	CDD:285248
		Reelin_repeat_8_subrepeat_2	3267..3427	CDD:197360
		BNR 16	3363..3374
CG17739	NP_610757.1	Reeler	23..163	CDD:260081	33/124 (27%)
		Spond_N	186..373	CDD:283999	33/198 (17%)
		TSP1	412..460	CDD:214559	7/50 (14%)
		TSP1	490..541	CDD:214559	12/45 (27%)
		KU	661..715	CDD:294074
		TSP_1	815..862	CDD:278517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S10216
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950