DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Relb and Dif

DIOPT Version :9

Sequence 1:	NP_033072.2	Gene:	Relb / 19698	MGIID:	103289	Length:	558	Species:	Mus musculus
Sequence 2:	NP_001162998.1	Gene:	Dif / 35045	FlyBaseID:	FBgn0011274	Length:	987	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	132/417 - (31%)
Similarity:	197/417 - (47%)	Gaps:	69/417 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    34 DELEIIDEYIKENGFGLDG-----------------TQLSEMPRLVPRGPASLSSVTLGPAAPPP 81
            |..|||:..::.||....|                 :|.:.:|.:....|..|.:..:....|.|
  Fly     8 DIQEIINASMELNGGATGGGSVAGAVGGGGAAHHILSQSTSLPVMPSHIPLHLQNQNMNQNLPEP 72

Mouse    82 PATPSWSCTLGRLVSPGPCPRPYLVITEQPKQRGMRFRYECEGRSAGSILG-ESSTEASKTLPAI 145
            .|...                |:|.|.|:|....:||||:||||:||||.| .||:|..||.|.|
  Fly    73 SARSG----------------PHLRIVEEPTSNIIRFRYKCEGRTAGSIPGMNSSSETGKTFPTI 121

Mouse   146 ELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKD----CTDGVCRVRLRPHVSPRHSFNNLGIQ 206
            |:.:..|  .|.:....|..|.|.|.|||.||.|:    |..|:.:.:|.|. ..|.....:|||
  Fly   122 EVCNYDG--PVIIVVSCVTSDEPFRQHPHWLVSKEEADACKSGIYQKKLPPE-ERRLVLQKVGIQ 183

Mouse   207 CVRKKEIEAAIERKIQLGIDPYNAGSLKNHQE----VDMNVVRICFQASYRDQQGHLHRMDPILS 267
            |.:|.|:..::..:.:..|||:||..  :|::    ::...:|:|:||........: .:|||:|
  Fly   184 CAKKLEMRDSLVERERRNIDPFNAKF--DHKDQIDKINRYELRLCYQAFITVGNSKV-PLDPIVS 245

Mouse   268 EPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKEDISVVF------STASWEGRADF 326
            .|:|.|    :|||.|.|:...:....||:|:.:||:|:.|:||.|.|      ...:|...|:|
  Fly   246 SPIYGK----SSELTITRLCSCAATANGGDEIIMLCEKIAKDDIEVRFYETDKDGRETWFANAEF 306

Mouse   327 SQADVHRQIAIVFKTPPYEDLEISEPVTVNVFLQRLTDGVCSEPLPFTYLPRDHDSYGV------ 385
            ...||.:|:||.||||.|.:.||::.|.|.:.|.|.:||..|.||||.|.|..    |.
  Fly   307 QPTDVFKQMAIAFKTPRYRNTEITQSVNVELKLVRPSDGATSAPLPFEYYPNP----GTVTFARL 367

Mouse   386 -DKKRKRGLPDVLGELSSSDPHGIESK 411
             .|.::|...||..::.|.|.....:|
  Fly   368 QRKLKRRQELDVFQQILSLDSETTATK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Relb	NP_033072.2	RelB_leu_zip	1..75	CDD:292798	11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Leucine-zipper	22..50		6/15 (40%)
		RHD-n_RelB	103..274	CDD:143646	65/179 (36%)
		RHD_dimer	282..378	CDD:292797	40/101 (40%)
		RelB_transactiv	381..558	CDD:292799	8/38 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	387..391		1/3 (33%)
		Nuclear localization signal. /evidence=ECO:0000255	411..416		1/1 (100%)
Dif	NP_001162998.1	RHD-n_Dorsal_Dif	78..252	CDD:143647	66/183 (36%)
Dif	NP_001162998.1	RHD_dimer	256..358	CDD:292797	40/101 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3721
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391433at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8810
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24169
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4542
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.990