Protein Alignment Pitpnm2 and rdgB

DIOPT Version :9

• Sequence 1: XP_006530277.1
• Gene: Pitpnm2 / 19679
• MGIID: 1336192
• Length: 1385
• Species: Mus musculus
• Sequence 2: NP_001259535.1
• Gene: rdgB / 32340
• FlyBaseID: FBgn0003218
• Length: 1297
• Species: Drosophila melanogaster
• Alignment Length: 1475
• Identity: 616/1475 - (41%)
• Similarity: 813/1475 - (55%)
• Gaps: 329/1475 - (22%)

Mouse     1 MIIKEYRIPLPMTVDEYRIAQLYMIQKKSRNETHGQGSGVEILENRPYTDGPGGSGQYTHKVYHV 65
            |:|||||||||:||:||||||||||.||||.|:||:||||||:.|.||.|||||:||||.|:|||
  Fly     1 MLIKEYRIPLPLTVEEYRIAQLYMIAKKSREESHGEGSGVEIIINEPYKDGPGGNGQYTKKIYHV 65

Mouse    66 GMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDTGENNNVFNLSP 130
            |.|:|||.:|:|||:||.|.||:||||||||||:|||||||||:||||:|..|.|..:|||.||.
  Fly    66 GNHLPGWIKSLLPKSALTVEEEAWNAYPYTRTRYTCPFVEKFSLDIETYYYPDNGYQDNVFQLSG 130

Mouse   131 VEKSQLITDIIDIVKDPVPPSEYKTEEDPKLFQSVKTCRGPLSENWIQEY------KKRLLP--- 186
            .:....|.|:||||||.:...:|..|||||.|.|.||.||||:|:|::||      ||:..|
  Fly   131 SDLRNRIVDVIDIVKDQLWGGDYVKEEDPKHFVSDKTGRGPLAEDWLEEYWREVKGKKQPTPRNM 195

Mouse   187 -IMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLTMEKIRELEREVQ 250
             :|.|||:|:|||||||||:|:|:||||..||::|:|||||||.|||||:|||:|.||||||:.|
  Fly   196 SLMTAYKICRVEFRYWGMQTKLEKFIHDVALRKMMLRAHRQAWAWQDEWFGLTIEDIRELERQTQ 260

Mouse   251 LMLSRKMAQFSEEGPSELSKDS---------------------------------------ATKD 276
            |.|::||.     |..|.|.||                                       |:.|
  Fly   261 LALAKKMG-----GGEECSDDSVSEPYVSTAATAASTTGSERKKSAPAVPPIVTQQPPSAEASSD 320

Mouse   277 QASGTTSDPGSKNGEPLGRG--LKKQWSTSSKSSRS-----------SKRGA------------- 315
            :......|......:.:|.|  |......|::.|||           ..:||
  Fly   321 EEGEEEEDDDEDENDAIGTGVDLSANQGGSAQRSRSQSIQMAQKGKFGSKGALHSPVGSAHSFDL 385

Mouse   316 ---------SPSRHSISEWRMQSIARDSDEGSEEEFFDAHENLYCTEEKQAKDMTKWNSNDLM-D 370
                     :|.|| ::.|||:.:..||...|:|||||      |.:..:...:.||:|.:|: :
  Fly   386 QSKKPHAKTAPRRH-VANWRMERLEVDSKSNSDEEFFD------CLDTNETNSLAKWSSLELLGE 443

Mouse   371 KMESPEP---------------EESQDEIYQQS---------GSEFRVASSVEQLNIIEDEVSQP 411
            ..:||.|               ...:|.|:.|.         |::.::.||.   ::.....|.|
  Fly   444 GDDSPPPHGGPSSAASVGGRGNSRQEDSIFNQDFLMRVASERGNKRQLRSSA---SVDRSHDSSP 505

Mouse   412 LAAP--PS-KIHVLLLVLHGGTILDTGAGDPSSKQGDTNTITNVFDTVMRVHYPSALGHLAIRLV 473
            ..:|  || ...:|:||:|.|::|| .|.:.::|:.|..|....|:.|||.||||.|.|:.|::|
  Fly   506 PGSPSTPSCPTTILILVVHAGSVLD-AASELTAKKSDVTTFRGSFEAVMRQHYPSLLTHVTIKMV 569

Mouse   474 PCPPICADAFALVSNLSPYGHDEGCLSSSQD-----HIPLAALPLLATSSPQYQEAVATVIQRAN 533
            |||.||.||..::|:||||..|..  .|:.|     .:|:.|:|||:.:||::.|.|...:..||
  Fly   570 PCPSICTDALGILSSLSPYSFDAS--PSAADIPNIADVPIGAIPLLSVASPEFHETVNKTVAAAN 632

Mouse   534 LAYGDFIKSQEGVTFNGQVCLIGDCVGGILAFDALCYSGQPVSESQSSSRRGSVVSMQDADLLSP 598
            :.|.:|:||:||..|:||:.::||.:|.:||::|||.|            .||          .|
  Fly   633 IVYHEFLKSEEGHGFSGQIVMLGDSMGSLLAYEALCRS------------NGS----------QP 675

Mouse   599 GTLANAAHCSGGSGGGGSGGSSLESSRHLSRSNIDIPRSNGTEDSRRQLPRKRSDSSTYELDTIQ 663
            ||      .||.|..||...:::.:...||      ||::..:|..|.:          |.|
  Fly   676 GT------ASGASNSGGDAATNINTHNPLS------PRNSRLDDDERFI----------EAD--- 715

Mouse   664 QHQAFLSSLHASVLRNEPSSRRSSSSTMLDGAGALGKFDFEIADLFLFGCPLGLVLALR-----K 723
                    |.|..|...||.||..||:..|....  |.|||:.|.|:||.||.:|||.|     |
  Fly   716 --------LDAKRLLVAPSPRRRRSSSSSDSRAT--KLDFEVCDFFMFGSPLSVVLAARKLHDAK 770

Mouse   724 TVIPSLDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHSLPPFSIPRYQRYPLGDGCSTLLV 788
            ..:|       ||.|.||||||||.||.||||||||..||..|.|.::|||.:||||:|....|:
  Fly   771 AALP-------RPNCHQVYNLFHPTDPIASRLEPLLSARFSILAPVNVPRYAKYPLGNGQPLHLL 828

Mouse   789 ETVQRNPELVLEGGPLAPLPHGDSFLETSIPVPALTWQDGPRQSLGCSESDVLQTHNTVFQEHAA 853
            |.:|.:|:...:|..|.
  Fly   829 EVIQSHPQHFNDGNNLL------------------------------------------------ 845

Mouse   854 PSSPGTAPAGRGFRRASEISIASQVSGMAESYTASSIAQKGPSSLNHTPSIRRLSLLALPPPSPT 918
                    ||   ||.|:.|:.|.:||:.|:.:.|:|         |.
  Fly   846 --------AG---RRLSDASMQSTISGLIENVSLSTI---------HA----------------- 873

Mouse   919 TQGPRARARQVSPNLERAPCLPDLDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASY 983
                                        :..||||.||:|||||||:.|:.||..||||||||||
  Fly   874 ----------------------------LQNKWWGTKRLDYALYCPEGLSNFPAHALPHLFHASY 910

Mouse   984 WESTDVVSFLLRQVMRHDSSSIL-ELDGKEVSVFTPSQPRERWQRKRTHVKLRNVAANHRINDAV 1047
            |||.||::|:|||:.:.:....: ..|.|:.:.|.|.||||:|.:|||.|||:|||||||.||.:
  Fly   911 WESPDVIAFILRQIGKFEGIPFVGSNDDKDNASFHPGQPREKWIKKRTSVKLKNVAANHRANDVI 975

Mouse  1048 ANEDGPQVVTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLHLDTLVTNSSGRVSYTIPETHRL 1112
            ..|...|.:..|||||||||:||.|||||||||..||:|||..|.|.||:.:||:||:||:...|
  Fly   976 VQEGREQRLNARFMYGPLDMITLHGEKVDVHIMKDPPAGEWTFLSTEVTDKNGRISYSIPDQVSL 1040

Mouse  1113 GVGVYPIKMVVRGDHTFADSYITVLPRGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQ 1177
            |.|:||:|||||||||..|.|:.|:|..||.|||||||||.||:|:.|.|||||||||||.||||
  Fly  1041 GYGIYPVKMVVRGDHTSVDCYMAVVPPLTECVVFSIDGSFTASMSVTGRDPKVRAGAVDVCRHWQ 1105

Mouse  1178 DLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRAHA 1242
            :||||:||:|||||||:||||:||:|||||||::||.|||..|||.||..:|..|:....:...|
  Fly  1106 ELGYLLIYITGRPDMQQQRVVSWLSQHNFPHGLISFADGLSTDPLGHKTAYLNNLVQNHGISITA 1170

Mouse  1243 AYGSTKDVAVYNSISLSPMHIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNTATRM 1307
            ||||:||::||.::.:....|:|||:..||||.....::||||||||.|:....:|||:..| ||
  Fly  1171 AYGSSKDISVYTNVGMRTDQIFIVGKVGKKLQSNATVLSDGYAAHLAGLQAVGGSRPAKGNA-RM 1234

Mouse  1308 ALRKGSFGLPGQSDFLRSRNHL----LRTISA------QPSGPSH 1342
            .:.:|.|.||||:...|.|::.    |..||.      .||..:|
  Fly  1235 VIPRGCFNLPGQTANPRRRSNAFELQLANISPSSSNINSPSSGNH 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pitpnm2	XP_006530277.1	SRPBCC_PITPNM1-2_like	1..258	CDD:176898	174/266 (65%)
		DDHD	704..998	CDD:367219	100/298 (34%)
		SMP2	<1041..>1190	CDD:227415	97/148 (66%)
		LNS2	1144..1275	CDD:197870	82/130 (63%)
rdgB	NP_001259535.1	SRPBCC_PITPNM1-2_like	1..268	CDD:176898	174/266 (65%)
		DDHD	746..924	CDD:280937	99/297 (33%)
		LNS2	1072..1203	CDD:197870	82/130 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I787
eggNOG	1	0.900	-	-		E1_COG5083
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7915
Inparanoid	1	1.050	1028	1.000	Inparanoid score	I274
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48872
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002342
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104036
Panther	1	1.100	-	-	LDO	PTHR10658
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3231
SonicParanoid	1	1.000	-	-		X1383
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860