DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbpj and Su(H)

DIOPT Version :9

Sequence 1:	XP_006503859.1	Gene:	Rbpj / 19664	MGIID:	96522	Length:	529	Species:	Mus musculus
Sequence 2:	NP_001285948.1	Gene:	Su(H) / 34881	FlyBaseID:	FBgn0004837	Length:	594	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	364/484 - (75%)
Similarity:	411/484 - (84%)	Gaps:	22/484 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse    40 QMHHNILSIWKFGERPPP-------KRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFC 97
            ||..::|        |.|       |:|||:||..|::||.|..::|||||||||||||||||||
  Fly    86 QMQMSLL--------PGPYRPHIEEKKLTRDAMEKYMRERNDMVIVILHAKVAQKSYGNEKRFFC 142

Mouse    98 PPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDS 162
            ||||:||.||||:::.|:|.:.|..||.:|.|||||||:|||:||||:|.||.||.||||:||||
  Fly   143 PPPCIYLFGSGWRRRYEEMLQQGEGEQGAQLCAFIGIGSSDQDMQQLDLNGKQYCAAKTLFISDS 207

Mouse   163 DKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTV 227
            ||||||||||||||||..|||||.||||||||||||||||||||||||||||.||||||||||||
  Fly   208 DKRKHFMLSVKMFYGNGHDIGVFNSKRIKVISKPSKKKQSLKNADLCIASGTNVALFNRLRSQTV 272

Mouse   228 STRYLHVEGGNFHASSQQWGAFYIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLI 292
            ||||||||.|:|||||.|||||.||||||:|||.|||.|||||||||.|||||||||||||||||
  Fly   273 STRYLHVENGHFHASSTQWGAFTIHLLDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLI 337

Mouse   293 IRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGASW 357
            |||||||.|||:||||||||||||||:|||:|||||||||:||||||||||||.|||||||||.|
  Fly   338 IRKVDKQMALLEADDPVSQLHKCAFYMKDTDRMYLCLSQEKIIQFQATPCPKEPNKEMINDGACW 402

Mouse   358 TIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAET 422
            ||||||||||.||||||||.:||||||:|.||.||||||||||||:|.||||:|:||||||||||
  Fly   403 TIISTDKAEYQFYEGMGPVASPVTPVPIVNSLNLNGGGDVAMLELSGDNFTPHLQVWFGDVEAET 467

Mouse   423 MYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGVIYSTSLTFTYTPEPGPRPHCSA-A 486
            ||||.|::|||||:||.||..|.|||||.|||::||||||:||:|.|||||||||||||||:. |
  Fly   468 MYRCTETLLCVVPEISQFRGEWLWVRQPTQVPISLVRNDGIIYATGLTFTYTPEPGPRPHCNTQA 532

Mouse   487 GAILRA----NSSQVP--SNESNTNSEGN 509
            ..::||    |::.:.  ||.:|:|:.|:
  Fly   533 EDVMRARQNNNNNNITSISNNNNSNNAGS 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbpj	XP_006503859.1	LAG1-DNAbind	77..202	CDD:370399	97/124 (78%)
		BTD	208..357	CDD:370398	133/148 (90%)
		IPT_RBP-Jkappa	379..475	CDD:238581	74/95 (78%)
Su(H)	NP_001285948.1	LAG1-DNAbind	122..251	CDD:286370	101/128 (79%)
		BTD	253..402	CDD:286369	133/148 (90%)
		IPT_RBP-Jkappa	424..520	CDD:238581	74/95 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840820
Domainoid	1	1.000	279	1.000	Domainoid score	I1689
eggNOG	1	0.900	-	-		E1_KOG3743
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7511
Inparanoid	1	1.050	745	1.000	Inparanoid score	I582
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48640
OrthoDB	1	1.010	-	-		D323392at33208
OrthoFinder	1	1.000	-	-		FOG0002244
OrthoInspector	1	1.000	-	-		oto94855
orthoMCL	1	0.900	-	-		OOG6_104439
Panther	1	1.100	-	-	LDO	PTHR10665
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3206
SonicParanoid	1	1.000	-	-		X1483
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800