DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbm6 and CG4887

DIOPT Version :9

Sequence 1:	NP_035381.2	Gene:	Rbm6 / 19654	MGIID:	1338037	Length:	1118	Species:	Mus musculus
Sequence 2:	NP_001259859.1	Gene:	CG4887 / 33304	FlyBaseID:	FBgn0031318	Length:	1004	Species:	Drosophila melanogaster

Alignment Length:	1245	Identity:	256/1245 - (20%)
Similarity:	415/1245 - (33%)	Gaps:	451/1245 - (36%)

- Green bases have known domain annotations that are detailed below.

Mouse    72 SFSYGGRDGPHGDYQGGEGPGHDFR---GGDFSSSDFQSRDSAQLDFRNRDIHSG--------DF 125
            |||.|..:      :||.|..: :|   |..:|.|..:||:      |||. |.|        ..
  Fly     8 SFSGGSEN------EGGRGSDY-YRSRPGSRYSRSRSRSRE------RNRS-HGGIRHRNSRSRS 58

Mouse   126 RDREGPPM----DYRGGDGTPMDYRGRETPHM-------NYRDRDSHTVDFRSRDVPPTDFRGRG 179
            |||:..|:    .:|||.|.    .|...|.:       :|||:|....:.|| :.....||...
  Fly    59 RDRDRSPVFRNDQHRGGRGG----AGNGDPDLYHSLINDDYRDQDERNYNSRS-NFENRQFRRHD 118

Mouse   180 TYDLDFRGREGSHSDFRGRDLSDLDFRSRDQSRSDFRNRDVSDLDFRDKDGTQVDFRGRGSATTD 244
            ::|...|.|:| .||   |:|:|.::..|.:           |||.||:..|
  Fly   119 SFDRRHRDRDG-ESD---RELNDYEYEQRSR-----------DLDSRDRSST------------- 155

Mouse   245 LDFRNRDTPHSDFRGRHRTRTYQDFRGREVGPCMEFKDREMPPMDPKVLDYIQPSPQEREHSGMN 309
                :||..|:..|.|..:|.:......:                            :|..|
  Fly   156 ----DRDWYHNRSRSREHSRPWNRNNNHD----------------------------DRSRS--- 185

Mouse   310 MNKREESIHDHAMERPAFGVQKGEFEHSETREGETQSGTFEHESQSDFQNSQSPVQEQDKPKLSG 374
             |:|.....||.|                     ...|...|....|....:...:|:|:.:...
  Fly   186 -NERNTRHRDHRM---------------------YNGGGSNHNRDRDRDRDREQDRERDRDRDRD 228

Mouse   375 GEQQSSDAGLFKEEGDLDFLGQQDTDYRSIEYCDVDHRLPGNQIFGYGQSKSFSQGKMSRDAQQD 439
            .|::.|                  :||.|                        .:|.|.|:
  Fly   229 RERRGS------------------SDYDS------------------------DEGHMRRN---- 247

Mouse   440 LQDQDYRTGPSEEKPNRLIRLSGVPENATKEEILNAFRTSDGIPVKDLQLKEYNTGYDYGYVCVE 504
                .||   |..:...:|.:.|:.:..|:.:|::.....:..|.....:::..|....|...||
  Fly   248 ----KYR---STTEALNIIIIFGLTKEMTRADIMSELIKVNMEPACIRIIRKQGTDSSRGIAFVE 305

Mouse   505 FSLLEDAIGCMEANQGTLMIHDKEVTLEYVPSP-DFWYCKRCKASTGGHQSSCSFCKGPKEEVKQ 568
            |:.:|:|...|:..||.|.::|:.|::.|.... ..|.|.:|.......:..|..||..:|
  Fly   306 FNTVEEAKQWMDITQGVLKLNDERVSMRYSHKRIQDWNCNKCGVCNFKFRFYCFVCKTSRE---- 366

Mouse   569 ELVSYPQPQKTSIPVPSEKQPNQPRPADKEHELRKREEGQESRLGHQKRDTERYFPHSRREGLTF 633
                                                             |:|..| .|..||:
  Fly   367 -------------------------------------------------DSETTF-SSGSEGV-- 379

Mouse   634 RRDREKEPWSGDSRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVHL-----TTANVRIIKNRTGP 693
                       |......:|.|||:.:...|..|.::..|:  :||     |.:.|.|.::....
  Fly   380 -----------DEVSTILTKKIMLRNLDALTNEEAVLTALQ--LHLKDLSKTVSKVLISRDSLTQ 431

Mouse   694 MGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAV-----------------NLATGKRRN 741
            ......::..|:..:::.|...|..||||.::|.::||:                 .||......
  Fly   432 ASRGICYLHFDTLVDSMNVHNALTALDPPLTLDDRVVAITYCIDLEEQQALPKNPKELAVKDSTV 496

Mouse   742 DSGDHS--------------------------------DHMHY--YQGKKYFRDRRGGNRNSD-- 770
            :||:.|                                :|.:|  |..:.|..|....||:|.
  Fly   497 NSGNISAVSPSGLGGNYTLADVPRLAEYSASLYASNPAEHAYYVQYYTEYYTADINKNNRDSHLT 561

Mouse   771 ---------WSSDTNRQGQQSSSDC---------------------------------------- 786
                     .|:...:|.:.||.:.
  Fly   562 EANSGAAVALSAIQRKQKKMSSIETTITAAATAAAQAAAQVKATLAAQVASAPKGNDGKIYPTPD 626

Mouse   787 ---YIYDSTTGYYYDPLAGTYYDPNTQ--------------------------------QEVYVP 816
               |.||.|:|||||...|.||:.::|                                |||..
  Fly   627 VTQYQYDETSGYYYDSTTGLYYNAHSQYYYNNETGAYLYWDQRRSTYVLATPASTQAALQEVLA- 690

Mouse   817 QDPESPDEEEIKEKKSTSQGKSNSKKETSKRDGK--EKKDRGMTKFQESTSEGKPPLEDVFKKPL 879
             |.|...|||.|:.|....|..:.|.:.:|:..|  ||..:.:.:.::.|:...|  :.:....:
  Fly   691 -DAEQKGEEESKKAKEKEGGNKHDKVKVAKKIVKDMEKWAKQLNQKKDYTAVATP--QPILANEV 752

Mouse   880 PPT----------------VKKEESP----PPPKVVNPLIGLLGEYGGDSDYEEE----EEEEQA 920
            ..|                .|||...    .|...|.|:..|:..|||.||.||:    .:..|:
  Fly   753 ATTSRGNQGGYADVGFSILEKKERGKLNDYAPNPTVGPMNKLVNAYGGTSDSEEDNAASSQNTQS 817

Mouse   921 PPVQPRTAQPREEMTKKENEDDKLTDWNKLACLLCRRQFPNKEVLTKHQQLSDLHKQNLEIHRKI 985
            ..|.......         |:....|::||.||||:|.|.:.|:|.||.::|.|||:||   .|:
  Fly   818 SAVVSGGGGA---------EESDYVDFHKLTCLLCKRAFQSLEILQKHLKMSTLHKENL---AKL 870

Mouse   986 KQS-----EQELAYLER-REREGRFKEKG----NDRREKLQSFDSPERKRIKYSRETDSDRNPVD 1040
            .|:     |:.|||.:| :||..::.|..    |..||:.:.    |.|.::..::..:...|.
  Fly   871 NQNTSSSIEEALAYRDRAKERRLKYGESDPPPPNRSRERFEQ----EIKTLQSRQKQSTSATPA- 930

Mouse  1041 KEDTDTSSKGGCAQQATGWRKGAGLGYSHPGLGSSEEIEGRMRGPGGGPPGRTSKRQSNETYRDA 1105
             ....:|:.|....|..||.:|.|||..:.|.....|.:||....|.|  .::.:......|:..
  Fly   931 -MPISSSNVGSRLLQKMGWSEGQGLGRKNQGRTQIIEADGRSNYVGLG--NKSGQMIPGNDYKSY 992

Mouse  1106 VRRVMFARYK 1115
            ::::|..||:
  Fly   993 IKKMMKQRYE 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbm6	NP_035381.2	Pentapeptide_4	173..235	CDD:404485	18/61 (30%)
		RRM1_RBM6	456..533	CDD:409753	18/76 (24%)
		RRM2_RBM6	651..737	CDD:409979	24/107 (22%)
		OCRE_RBM6	763..828	CDD:293882	28/150 (19%)
		OCRE repeat 1	769..776	CDD:293882	2/17 (12%)
		OCRE repeat 2	785..792	CDD:293882	3/49 (6%)
		OCRE repeat 3	793..800	CDD:293882	5/6 (83%)
		OCRE repeat 4	801..807	CDD:293882	3/5 (60%)
		OCRE repeat 5	811..818	CDD:293882	3/6 (50%)
		G-patch	1046..>1079	CDD:396249	11/32 (34%)
CG4887	NP_001259859.1	DUF1777	115..>196	CDD:285811	28/144 (19%)
		RRM_SF	255..335	CDD:302621	18/79 (23%)
		ZnF_RBZ	341..364	CDD:197784	6/22 (27%)
		RanBP2-type Zn finger	342..361	CDD:275375	4/18 (22%)
		RRM1_RRM2_RBM5_like	387..473	CDD:240759	22/87 (25%)
		OCRE_RBM5_like	623..678	CDD:293881	13/54 (24%)
		OCRE repeat 1	628..635	CDD:293881	3/6 (50%)
		OCRE repeat 2	636..643	CDD:293881	5/6 (83%)
		OCRE repeat 3	644..651	CDD:293881	3/6 (50%)
		OCRE repeat 4	652..659	CDD:293881	1/6 (17%)
		OCRE repeat 5	661..668	CDD:293881	0/6 (0%)
		G-patch	935..979	CDD:279867	15/45 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843019
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D786674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810