DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARID2 and Arid2

DIOPT Version :9

Sequence 1:	NP_689854.2	Gene:	ARID2 / 196528	HGNCID:	18037	Length:	1835	Species:	Homo sapiens
Sequence 2:	NP_780460.3	Gene:	Arid2 / 77044	MGIID:	1924294	Length:	1828	Species:	Mus musculus

Alignment Length:	1835	Identity:	1689/1835 - (92%)
Similarity:	1744/1835 - (95%)	Gaps:	8/1835 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSE 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSE 65

Human    66 KNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSS 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 KNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSS 130

Human   131 YNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEK 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 YNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEK 195

Human   196 DPKIITLLLANAGVFDDTLGSFSTVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGT 260
            |||||||||||||||||||||||:||||||:|||||||||||||||||||||||||||||:||.|
Mouse   196 DPKIITLLLANAGVFDDTLGSFSSVFGEEWREKTDRDFVKFWKDIVDDNEVRDLISDRNKAHEDT 260

Human   261 SGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLRFLLLSAHSHFI 325
            .|||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
Mouse   261 PGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEESNVKLLAANRTCLRFLLLSAHSHFI 325

Human   326 SLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVL 390
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse   326 SLRQLGLDTLGNIAAELLLDPVDFRTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVL 390

Human   391 ICEYVDQDSYREIICHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDIQ 455
            |||||||||||||||||||||||||.||||||||||||||||||||||||||||:||||||||.|
Mouse   391 ICEYVDQDSYREIICHLTLPDVLLVTSTLEVLYMLTEMGDVACTKIAKVEKSIDVLVCLVSMDAQ 455

Human   456 MFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTHVASAPASRAVVAQHVAPPPGIVEIDS 520
            |||||||||||||||||||||:|||||||||||||||||:||.||||||||||.|||||||||||
Mouse   456 MFGPDALAAVKLIEHPSSSHQVLSEIRPQAIEQVQTQTHIASGPASRAVVAQHAAPPPGIVEIDS 520

Human   521 EKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVED 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 EKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVED 585

Human   586 SSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRVDSVPDVSPAPSPAGIPHGSQTIGNHF 650
            |:|:|||||||:||||||:||||||||||||:||.|||||:|.|:||.|||||||||.|..||||
Mouse   586 STSSGQAHIHVIGVKRRALPLPIQMYYQQQPISTPVVRVDAVADLSPTPSPAGIPHGPQAAGNHF 650

Human   651 QRTPVANQSSNLTATQMSFPVQGVHTVAQTVSRIPQNPSPHTHQQQNAPVTVIQSKAPIPCEVVK 715
            |||||.|||||||||||||||||:|||||||||||.|||.|||||||:||||||:||||||||||
Mouse   651 QRTPVTNQSSNLTATQMSFPVQGIHTVAQTVSRIPPNPSVHTHQQQNSPVTVIQNKAPIPCEVVK 715

Human   716 ATVIQNSIPQTGVPVSIAVGGGPPQSSVVQNHSTGPQPVTVVNSQTLLHHPSVIPQQSPLHTVVP 780
            |||||||:|||.|||||:|||.|.|:||.||||.|||||||||||||||||||:||.||||||||
Mouse   716 ATVIQNSVPQTAVPVSISVGGAPAQNSVGQNHSAGPQPVTVVNSQTLLHHPSVMPQPSPLHTVVP 780

Human   781 GQIPSGTPVTVIQQAVPQSHMFGRVQNIPACTSTVSQGQQLITTSPQPVQTSSQQTSAGSQSQDT 845
            ||:|||||||||||.||||.||||||:|||||||||||||||||||||:.||||||:||||.|||
Mouse   781 GQVPSGTPVTVIQQTVPQSRMFGRVQSIPACTSTVSQGQQLITTSPQPMHTSSQQTAAGSQPQDT 845

Human   846 VIIAPPQYVTTSASNIVSATSVQNFQVATGQMVTIAGVPSPQASRVGFQNIAPKPLPSQQVSSTV 910
            |||||||||||||||||||||||||||||||:||||||||||.|||||||||||||||||||.:|
Mouse   846 VIIAPPQYVTTSASNIVSATSVQNFQVATGQVVTIAGVPSPQPSRVGFQNIAPKPLPSQQVSPSV 910

Human   911 VQQPIQQPQQPTQQSVVIVSQPAQQGQTYAPAIHQIVLANPAALPAGQTVQLTGQPNITPSSSPS 975
            |||||||||||.|||||||||||||||.|||||||||||||||||||||||||||||||||||||
Mouse   911 VQQPIQQPQQPAQQSVVIVSQPAQQGQAYAPAIHQIVLANPAALPAGQTVQLTGQPNITPSSSPS 975

Human   976 PVPATNNQVPTAMSSSSTPQSQGPPPTVSQMLSVKRQQQQQHSPAPPPQQVQVQVQQPQQVQMQV 1040
            |||.||||||||||||||.||||||||||||||||||||||||||.|.||||||||||||||:||
Mouse   976 PVPPTNNQVPTAMSSSSTLQSQGPPPTVSQMLSVKRQQQQQHSPAAPAQQVQVQVQQPQQVQVQV 1040

Human  1041 QPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVASNQ 1105
            ||||.:|||||||..|||||||||||||||||||||||||||||||||||||||||||||||:||
Mouse  1041 QPQQPSAGVGQPAPNESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVANNQ 1105

Human  1106 AAGFGVQGQTPAQQLLVGQQNVQLVPSAMPPSGGVQTVPISNLQILPGPLISNSPATIFQGTSGN 1170
            |||||||||||||||||||||||||.|||||:|||||||||||||||||||||||||||||||||
Mouse  1106 AAGFGVQGQTPAQQLLVGQQNVQLVQSAMPPAGGVQTVPISNLQILPGPLISNSPATIFQGTSGN 1170

Human  1171 QVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLPVQTLPATQASPAGQSSCTTATP 1235
            |||||||||||||.||||||||.|||||||::|||.|...||.||||      |||||:||||..
Mouse  1171 QVTITVVPNTSFATATVSQGNAAQLIAPAGLSMSGAQASAGLQVQTL------PAGQSACTTAPL 1229

Human  1236 PFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNTSNGDTKENEMHVGSLLNGRKYS 1300
            |||||||||||||||||||||||||||||||||||||||.||||||||.|:|:.|||||||||||
Mouse  1230 PFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGTTNTSNGDTSESELQVGSLLNGRKYS 1294

Human  1301 DSSLPPSNSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQIDMQDIKSDLRKPLVNGICDFD 1365
            |||||||||||:||||:||||||||||||||||||.||||||.:||||:|.||:|.|||||||||
Mouse  1295 DSSLPPSNSGKLQSETSQCSLISNGPSLELGENGAPGKQNSEPVDMQDVKGDLKKALVNGICDFD 1359

Human  1366 KGDGSHLSKNIPNHKTSNHVGNGEISPMEPQGTLDITQQDTAKGDQLERISNGPVLTLGGS-SVS 1429
            |||||||||||||||||||||||||||:|||||...|||||||||||||:||||||||||| |.|
Mouse  1360 KGDGSHLSKNIPNHKTSNHVGNGEISPVEPQGTSGATQQDTAKGDQLERVSNGPVLTLGGSPSTS 1424

Human  1430 SIQEASNAATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSVIQGHQIIAVPDSGSKVS 1494
            |:|||.:.||...|||||.||||||||||||||||||||||||||..||||||:||||.||.:|:
Mouse  1425 SMQEAPSVATPPLSGTDLPNGPLASSLNSDVPQQRPSVVVSPHSTAPVIQGHQVIAVPHSGPRVT 1489

Human  1495 HSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTISDPNNAGCSATMVAVPAG 1559
            .| |||||.||||||||||||||||||.||:||.|||||||||||||||||||||||||||||||
Mouse  1490 PS-ALSSDARSTNGTAECKTVKRPAEDNDRDTVPGIPNKVGVRIVTISDPNNAGCSATMVAVPAG 1553

Human  1560 ADPSTVAKVAIESAVQQKQQHPPTYVQNVVPQNTPMPPSPAVQVQGQPNSSQPSPFSGSSQPGDP 1624
            ||||||||||||||.||||||||||:|:|.||||||||||||||||||:||||||.|.|||..||
Mouse  1554 ADPSTVAKVAIESAAQQKQQHPPTYMQSVAPQNTPMPPSPAVQVQGQPSSSQPSPVSASSQHADP 1618

Human  1625 MRKPGQNFMCLWQSCKKWFQTPSQVFYHAATEHGGKDVYPGQCLWEGCEPFQRQRFSFITHLQDK 1689
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1619 VRKPGQNFMCLWQSCKKWFQTPSQVFYHAATEHGGKDVYPGQCLWEGCEPFQRQRFSFITHLQDK 1683

Human  1690 HCSKDALLAGLKQDEPGQAGSQKSSTKQPTVGGTSSTPRAQKAIVNHPSAALMALRRGSRNLVFR 1754
            ||||||||||||||||||..:|||||||||||||.|.|||||||.:|||||||||||||||||||
Mouse  1684 HCSKDALLAGLKQDEPGQVANQKSSTKQPTVGGTGSAPRAQKAIASHPSAALMALRRGSRNLVFR 1748

Human  1755 DFTDEKEGPITKHIRLTAALILKNIGKYSECGRRLLKRHENNLSVLAISNMEASSTLAKCLYELN 1819
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1749 DFTDEKEGPITKHIRLTAALILKNIGKYSECGRRLLKRHENNLSVLAISNMEASSTLAKCLYELN 1813

Human  1820 FTVQSKEQEKDSEML 1834
            |||||||||||||||
Mouse  1814 FTVQSKEQEKDSEML 1828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARID2	NP_689854.2	ARID	19..101	CDD:279697	81/81 (100%)
		LXXLL	313..317		3/3 (100%)
		RFX_DNA_binding	521..601	CDD:280427	76/79 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..844		20/24 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..919		22/24 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..1057		85/94 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1266..1287		18/20 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1295..1314		17/18 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1321..1341		18/19 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1488..1522		26/33 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1572..1629		46/56 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1703..1728		19/24 (79%)
Arid2	NP_780460.3	ARID	19..101	CDD:307514	81/81 (100%)
		LXXLL. /evidence=ECO:0000250\|UniProtKB:Q68CP9	313..317		3/3 (100%)
		RFX_DNA_binding	521..601	CDD:308073	76/79 (96%)
		Atrophin-1	603..>910	CDD:331285	269/306 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..843		15/18 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..1028		61/65 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1339		84/93 (90%)
		Sec23_BS	1278..>1575	CDD:331630	255/297 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1360..1462		86/101 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1483..1503		13/20 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1566..1618		42/51 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1697..1726		23/28 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83972950
Domainoid	1	1.000	2195	1.000	Domainoid score	I244
eggNOG	1	0.900	-	-		E1_KOG2312
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14601
Inparanoid	1	1.050	3381	1.000	Inparanoid score	I449
Isobase	1	0.950	-	0	Normalized mean entropy	S8064
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47775
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006621
OrthoInspector	1	1.000	-	-		oto122848
orthoMCL	1	0.900	-	-		OOG6_107188
Panther	1	1.100	-	-	LDO	PTHR22970
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4843
SonicParanoid	1	1.000	-	-		X5621
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.240