DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARID2 and arid2

DIOPT Version :9

Sequence 1:	NP_689854.2	Gene:	ARID2 / 196528	HGNCID:	18037	Length:	1835	Species:	Homo sapiens
Sequence 2:	XP_005164514.1	Gene:	arid2 / 566352	ZFINID:	ZDB-GENE-030131-6311	Length:	1572	Species:	Danio rerio

Alignment Length:	1854	Identity:	1020/1854 - (55%)
Similarity:	1187/1854 - (64%)	Gaps:	312/1854 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     1 MANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSE 65
            |||||||..|::||||.|||||||||||||||||||:|.||||||||..||.||.:||||||||:
Zfish     1 MANSTGKNLPEQRRKGQAFLDELRQFHHSRGSPFKKVPVVGGKELDLGALYVRVVSLGGFAKVSD 65

Human    66 KNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSS 130
            ||||.|:||:|.||||||||||.||||||||||||||||||||:|:|..|||||..|||||||:|
Zfish    66 KNQWVELVEDFQFPRSCSNAAFVLKQYYLRYLEKYEKVHHFGEEDEEEQPGNPKHLLPIGAIPTS 130

Human   131 YNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEK 195
            ||||||:||||||||||||.||..|:|||||||||||||||||||||||||||||||||.|||||
Zfish   131 YNYQQHTVSDYLRQSYGLSTDFIPPSDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHAMQLEK 195

Human   196 DPKIITLLLANAGVFDDTLGSFSTVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRN-KSHEG 259
            :||::|||||:||||||:|||||.|||.:|:|||.||||:||||:::||||:|||||:: ....|
Zfish   196 EPKLVTLLLAHAGVFDDSLGSFSAVFGTDWQEKTSRDFVRFWKDVIEDNEVKDLISDKSCTPQNG 260

Human   260 TSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLRFLLLSAHSHF 324
            .....|...||||.|..||.|:|||||||:|:|||||||||.|:|||||||||||||||.||..|
Zfish   261 LELRDICTPLFHPARNTGIGDVEGQRVLQVAMILRNLSFEEANIKLLAANRTCLRFLLLCAHCTF 325

Human   325 ISLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGV 389
            |.|||||||||||.|.||.||||||:||||||||:||||:|||||||||.|||||||.|.|||||
Zfish   326 IQLRQLGLDTLGNFAGELQLDPVDFRTTHLMFHTITKCLLSRDRFLKMRAMEILGNLSKVEDNGV 390

Human   390 LICEYVDQDSYREIICHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDI 454
            ||||||||:||||||..||||||:||||.|||||.|.|:|::.|:||:.||:|||:||.|||:|:
Zfish   391 LICEYVDQESYREIIALLTLPDVMLVISALEVLYQLAELGEITCSKISSVERSIDLLVRLVSVDL 455

Human   455 QMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTHVASAPASRAVVAQHVAPPPGIVEID 519
            |.||||||.|||||||.:||.| :||:|||.:|.|...|....|..:|..|..  .|||||||||
Zfish   456 QTFGPDALTAVKLIEHQASSSQ-VSEVRPQLVEHVPAATQGTPAAVNRTPVQS--TPPPGIVEID 517

Human   520 SEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVE 584
            .|||..|||||||||:.|.||||:|||||||:||||:||||:|||..|||||||:||||||||||
Zfish   518 GEKFTTQWLNAHFEVHSDGSVSRSEMYSEYLATCSKMARGGVLTSNNFYKCLRTLFPNHTVKRVE 582

Human   585 DSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRVDSVPDVSPAPSP------------A 637
            |:..||||.||||||::||||||:|:|||||.           ...||||.|            :
Zfish   583 DTRLNGQAQIHVVGVRKRAIPLPVQLYYQQQQ-----------QQASPAPVPKHEAPSETPQAHS 636

Human   638 GIPHGSQTIGNHFQRTPVANQSSNLTATQMSFPVQGVHTVAQTVSRIPQNPSPH-----THQQQN 697
            .:|.|   :|....|.|..:.::...|.|::|.:.     |..::..|..|:|.     ..|...
Zfish   637 ALPPG---VGGQPVRAPAPSLTAGQAAPQVAFTMH-----APPLANAPSAPAPRPPLNPPGQAAL 693

Human   698 APVTVIQSKAPI-PCEVVKATVIQNSIPQTGVPVSIAVGGGPPQSSVVQNHSTGPQPVTVVNSQT 761
            .|.....:..|| |.:::|..:||:|||....            :..|.|||...      ..|.
Zfish   694 PPCPPAAAPVPIRPNDILKTAMIQSSIPTASA------------APAVPNHSGSS------TQQP 740

Human   762 LLHHPSVIPQQSPLHTVVPGQIPSGTPVTVIQQA-VPQSHMF-GRVQNIPACTSTVSQGQQLITT 824
            ||||                     .||.:|||. .||.|:| |:|..:  |||.   |||
Zfish   741 LLHH---------------------APVALIQQGPPPQGHVFTGQVHGV--CTSV---GQQ---- 775

Human   825 SPQPVQTSSQQTSAGSQSQDTVIIAPPQYVTTSASNIVSATSVQNFQVATGQMVTIAGVPSPQAS 889
            .||            :.||:.:::|.||||||..:.:          :|.||:||:|||   ..|
Zfish   776 RPQ------------APSQEAMVLAQPQYVTTPCTPL----------MAGGQVVTVAGV---TGS 815

Human   890 RVGFQNIAPKPLPSQQVSSTVVQQPIQQPQQPTQQSVVIVSQPAQQGQTYAPAIHQIVLANPAAL 954
            ||.||||||||       :..||.|...|.||  ||:||||...|....:|||||||||.||
Zfish   816 RVAFQNIAPKP-------THQVQSPQPPPTQP--QSLVIVSPNQQPNTAFAPAIHQIVLTNP--- 868

Human   955 PAGQTVQLTGQPNITPSSSPSPVPATNNQVPTAMSSSSTPQSQGPPPTVSQMLSVKRQQQQQHSP 1019
                      .|..||:.: ||..|..|..|.            .|.|||||||||||.|    |
Zfish   869 ----------NPQQTPAPT-SPNAAVPNPAPV------------QPHTVSQMLSVKRQFQ----P 906

Human  1020 APPPQQVQVQVQQPQQVQMQVQPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQI 1084
            .|||....|                      ||.|.||||||||||||||||||||||||||||:
Zfish   907 TPPPAASPV----------------------QPTSTESSLIKQLLLPKRGPSTPGGKLILPAPQV 949

Human  1085 PPPNNARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQQNVQLVPSAMPPSGGVQTVPISNLQ 1149
            |.|.:.|||||||||||.::        ...|.|.    |.||||:.|   |.    .||||
Zfish   950 PAPVSTRAPSPQVVYQVTNS--------APVPPQP----QLNVQLMQS---PG----AVPIS--- 992

Human  1150 ILPGPLISNSPA-TIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLP 1213
            ||||.:||.|.: ||.|.|..||||.|||||:.|.    .||..|    |..|.:..|||
Zfish   993 ILPGQIISTSTSGTILQATPSNQVTFTVVPNSGFP----GQGVQT----PPTIGLQLTQT----- 1044

Human  1214 VQTLPATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNT 1278
             ..||...|:|         .|||:|||||||||||||:||||||||||||||||.|....:...
Zfish  1045 -PPLPVAGATP---------IPPFRGDKIICQKEEEAKDATGLHVHERKIEVMENNSIADASAKA 1099

Human  1279 SNGDTKENEMHVGSLLNGRKYSDSSLPPSNSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQ 1343
            |||:|.|.|  ...||||||: ||||||.:||...||.      .|||   :.::|..|||.
Zfish  1100 SNGETAEAE--APKLLNGRKF-DSSLPPYHSGNSPSEA------PNGP---VAQSGCDGKQT--- 1149

Human  1344 IDMQDIKSDLRKPLVNGICDFDKGD-GSHLSKNIPNHKTSNHVGNGEISPMEPQGTLDITQQDTA 1407
                  .:|.:|.:|||:|||::.| .||.||||||||.|.|:||||:...:..|.|.:. :|||
Zfish  1150 ------PADPKKLMVNGVCDFERSDAASHPSKNIPNHKASKHMGNGEVLSPKAHGALGLA-EDTA 1207

Human  1408 KGDQLERISNGPVLTLGGSSVSSIQEASNAATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPH 1472
            :.:..||::|||.                      .|.||.|||.:.:| |..||.      :||
Zfish  1208 RAEPPERLANGPC----------------------HGADLSNGPSSETL-SLRPQH------APH 1243

Human  1473 STTSVIQGHQIIAVPDSGSKVSHS-PALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGV 1536
                                 :|| |..:.:..|.|||||.:|:|||.||.||.|.| ||.|:||
Zfish  1244 ---------------------NHSPPPATPNPPSANGTAESRTLKRPLEDADRGTSA-IPAKMGV 1286

Human  1537 RIVTISDPNNAGCSATMVAVPAGADPSTVAKVAIESAVQQK----QQHPPTYVQNVVPQNTPMPP 1597
            ||||||||||||.||||||||||||||||||||||:|.||:    ...|.|..|..|...||.|.
Zfish  1287 RIVTISDPNNAGNSATMVAVPAGADPSTVAKVAIENAAQQRPSVPSPLPETNAQQPVSVQTPPPV 1351

Human  1598 SPAVQVQGQPNSSQPSPFSGSSQPGDPMRKPGQNFMCLWQSCKKWFQTPSQVFYHAATEHGGKDV 1662
            .||.|   ..|.|.|:|.....|    .|||||||.||||:||:||.|||||||||||.||.||.
Zfish  1352 DPAAQ---GTNQSSPAPALSPEQ----TRKPGQNFKCLWQACKRWFDTPSQVFYHAATLHGSKDS 1409

Human  1663 YPGQCLWEGCEPFQRQRFSFITHLQDKHCSKDALLAGLKQDEPGQAGSQKSSTKQP--TVGGTSS 1725
            |||||.|||||||.|||.||||||||||||::||:|.||.:|..| ||..:::|.|  .|.....
Zfish  1410 YPGQCQWEGCEPFPRQRLSFITHLQDKHCSREALIAALKLEEQTQ-GSNPNTSKSPPAAVSSPPP 1473

Human  1726 TPRAQKAIVNHPSAALMALRRGSRNLVFRDFTDEKEGPITKHIRLTAALILKNIGKYSECGRRLL 1790
            .||..||:|||||||||||||||||||||||||:||||:||||||||||.||||.|||:|||:::
Zfish  1474 PPRPPKALVNHPSAALMALRRGSRNLVFRDFTDDKEGPVTKHIRLTAALTLKNIAKYSDCGRKMV 1538

Human  1791 KRHENNLSVLAISNMEASSTLAKCLYELNFTVQS 1824
            |||||:|||||:|:||.|:|||||||||..::|:
Zfish  1539 KRHENHLSVLALSSMEVSTTLAKCLYELTRSLQA 1572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARID2	NP_689854.2	ARID	19..101	CDD:279697	68/81 (84%)
		LXXLL	313..317		3/3 (100%)
		RFX_DNA_binding	521..601	CDD:280427	63/79 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..844		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..919		10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..1057		29/94 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1266..1287		9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1295..1314		12/18 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1321..1341		7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1488..1522		14/34 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1572..1629		20/60 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1703..1728		7/26 (27%)
arid2	XP_005164514.1	ARID	19..101	CDD:279697	68/81 (84%)
arid2	XP_005164514.1	RFX_DNA_binding	519..599	CDD:280427	63/79 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343464
Domainoid	1	1.000	805	1.000	Domainoid score	I793
eggNOG	1	0.900	-	-		E1_KOG2312
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14601
Inparanoid	1	1.050	1718	1.000	Inparanoid score	I663
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47775
OrthoDB	1	1.010	-	-		D21869at7742
OrthoFinder	1	1.000	-	-		FOG0006621
OrthoInspector	1	1.000	-	-		oto49463
orthoMCL	1	0.900	-	-		OOG6_107188
Panther	1	1.100	-	-	LDO	PTHR22970
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4843
SonicParanoid	1	1.000	-	-		X5621
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300