DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARID2 and rsc9

DIOPT Version :9

Sequence 1:	NP_689854.2	Gene:	ARID2 / 196528	HGNCID:	18037	Length:	1835	Species:	Homo sapiens
Sequence 2:	NP_596197.1	Gene:	rsc9 / 2539948	PomBaseID:	SPBC1703.02	Length:	780	Species:	Schizosaccharomyces pombe

Alignment Length:	892	Identity:	174/892 - (19%)
Similarity:	299/892 - (33%)	Gaps:	262/892 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    18 AFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVS-EKNQWGEIVEEFNFPRS 81
            :||..:..|...||.|....|.:|.|.:.|:.||.:|...||:..|| .::.|..|.|||| ...
pombe    25 SFLSLIESFSQERGVPIDINPKIGRKPILLYELYKKVIKRGGYDAVSATEDGWTNIAEEFN-QSD 88

Human    82 CSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGN-----------------------PKPQLP 123
            .:.:|..|:..|.:||..:|...|:   ...:||.:                       |||..|
pombe    89 PARSAGILQNVYFKYLISWEIHDHW---HLLLPPPSTLELSENRQNVLERVKVFNSCSPPKPTNP 150

Human   124 IGAIPSSYNYQQHSVSDYLR------QSYGLSMDFNS----------PNDYN------------- 159
            |..|.   |.:.||...:.:      :..|:....|.          ||..|
pombe   151 ITIID---NDKTHSFKKFYKSLVKEDEENGIEKKINEAMNSSASQPLPNSTNFASTTFPSVPFHP 212

Human   160 ---------------------------------KLVLSLLSGLPNEVDFAINVCTLLSNESKHVM 191
                                             ::.|:|.|....|||:||.....:|.|.....
pombe   213 LPVDSGLQKYIDRNSNLTPPALGAGVPGPPLLVRVALALKSQQDKEVDWAIGHLIKISFERHQEF 277

Human   192 QLEKDPKIITLLLANAGVFDDTLGSFSTVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRNKS 256
            :||:.|.:...|:.:.|        |.....::..:.||   :....|
pombe   278 KLERLPSLAECLVYSLG--------FQVTKAKQVSDLTD---ISLCMD----------------- 314

Human   257 HEGTSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRN--LSFEEGN--------VKLLAANRT 311
                                        |.:.||::|||  ||.|...        :.:|.|:..
pombe   315 ----------------------------RAIGIALVLRNSVLSVENAKHVAQTKLVISVLEASIR 351

Human   312 C------LRFLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFL 370
            |      |.||      |:.      ||....|::.|.::  |.|  ::.:..:.:.|.|.|..:
pombe   352 CAKTFNNLEFL------HYC------LDISEMISSYLHVE--DEK--NVFYLALCEFLNSSDYSI 400

Human   371 KMRGMEILGNLCKAEDNGVLICEYVDQDSYREIICHL----TLPDVLLVISTLEVLYMLTEMGDV 431
            .:..:..|..|...:.|..|:     ||....:|.::    ...:..:|.:.|:.||..|.....
pombe   401 LIATLRTLARLALNDRNNRLL-----QDLKSNVIANIIALVETDNEEIVAAALDFLYQYTTYRTN 460

Human   432 ACTKIAKVE--KSIDMLVCLVSMDIQMFGPDALAAVKL---IEHPSSSHQMLSEIRPQAIEQVQT 491
            ....:|..|  ..:|.|:.|:....|    :....|.:   ..:|:..|:..|.|   ::...:.
pombe   461 TSNLLASQEAWMLVDQLIRLMMYQAQ----ERFMTVTIENSESNPAVKHEATSSI---SLPMEEL 518

Human   492 QTHVASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKL 556
            |..||.....|:|                     :|:...||.:.|..|.:.:::..|   ||.:
pombe   519 QQLVAMREPERSV---------------------KWMRCCFEPSSDDYVLQTDIWQLY---CSDM 559

Human   557 ARG------GILTSTGFYKCLRTVFPNHTVKRVEDSSSNGQAHIHVV--GVKRRAIPLPIQ-MYY 612
            .|.      || :...|.|.....|.|.....|    |..|..:..|  |:|||..|..:. |.|
pombe   560 ERAQGPNVMGI-SPADFIKVSSHAFYNARAMTV----STPQLPVEYVINGIKRRKFPTSVNGMRY 619

Human   613 QQQPVSTSVVRVDSVPDVSPAPSPAGIPHGSQTIGNHFQRT---PVANQSSNLTATQMSFPVQGV 674
              ||....   :||..:...      :..|:..:.:|.|..   |...::.....:...:.:|.:
pombe   620 --QPCRWC---LDSGKECGE------LLLGTPLLHSHLQEMHIFPQILETGKCRWSDCKYEIQRL 673

Human   675 HTVAQTVSRIPQNPSPHTHQQQNAPVTVIQSKAPIPCEVVKATVIQNSIPQTGVPVSIAVGGGPP 739
             |.|..:|.........||...::..|:::.:...|....:..::..::...|....||:.....
pombe   674 -TPASELSHYQLLSHIVTHLHDDSLETLVEGRKLSPSREFRIPLLLTAVDDQGDATGIALTATLV 737

Human   740 QSSVVQNHSTGPQPVTVVNSQTL---LHHPSVIPQQSPLHTVVPGQI 783
            ..::|:: ..|....:.:.|:.|   ..:|:|.|..|.:   :.|||
pombe   738 LRNLVRS-KQGKMLFSAIESRVLEVSSLNPAVAPYVSEM---LLGQI 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARID2	NP_689854.2	ARID	19..101	CDD:279697	28/82 (34%)
		LXXLL	313..317		2/3 (67%)
		RFX_DNA_binding	521..601	CDD:280427	20/87 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..844
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..1057
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1266..1287
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1295..1314
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1321..1341
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1488..1522
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1572..1629
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1703..1728
rsc9	NP_596197.1	BRIGHT	21..113	CDD:128777	29/88 (33%)
rsc9	NP_596197.1	ARM	<388..451	CDD:237987	12/67 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910