DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARID2 and arid2

DIOPT Version :9

Sequence 1:	NP_689854.2	Gene:	ARID2 / 196528	HGNCID:	18037	Length:	1835	Species:	Homo sapiens
Sequence 2:	XP_017947767.1	Gene:	arid2 / 100486517	XenbaseID:	XB-GENE-6070950	Length:	1816	Species:	Xenopus tropicalis

Alignment Length:	1855	Identity:	1419/1855 - (76%)
Similarity:	1559/1855 - (84%)	Gaps:	59/1855 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSE 65
            |:|||||..||.||||.||||||||||.||||.|||||||||:|||||.||||||||||||||||
Frog     1 MSNSTGKPEPDHRRKGQAFLDELRQFHESRGSGFKKIPAVGGRELDLHALYTRVTTLGGFAKVSE 65

Human    66 KNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSS 130
            |||||||.|:|:|||.|:||||||||||||||||||||||||||||||.|||||.||||||||.|
Frog    66 KNQWGEIGEDFSFPRGCANAAFALKQYYLRYLEKYEKVHHFGEDDDEVQPGNPKQQLPIGAIPCS 130

Human   131 YNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEK 195
            |||||||:.|||||||||:||||:|||||||||||||||||||||||||||||||||||||||||
Frog   131 YNYQQHSIPDYLRQSYGLTMDFNTPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEK 195

Human   196 DPKIITLLLANAGVFDDTLGSFSTVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGT 260
            |||||||||||||||||||||||.|||.|||||||||||:||||||:||||||||.|::.|..|:
Frog   196 DPKIITLLLANAGVFDDTLGSFSAVFGNEWKEKTDRDFVQFWKDIVEDNEVRDLIYDKSTSQAGS 260

Human   261 SGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLRFLLLSAHSHFI 325
            |.|.:||:||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
Frog   261 SPESLWEALFHPPRKLGINDIEGQRVLQIAVILRNLSFEESNVKLLAANRTCLRFLLLSAHSHFI 325

Human   326 SLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVL 390
            |||||||||||||||||.|||||||||||||||:||||||||||||||||||||||||||||.||
Frog   326 SLRQLGLDTLGNIAAELQLDPVDFKTTHLMFHTITKCLMSRDRFLKMRGMEILGNLCKAEDNAVL 390

Human   391 ICEYVDQDSYREIICHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDIQ 455
            ||||||||||:||||||:|||||||||||||||||||:|:|||.|||.||:|||.||||:|||||
Frog   391 ICEYVDQDSYKEIICHLSLPDVLLVISTLEVLYMLTELGEVACVKIANVERSIDTLVCLISMDIQ 455

Human   456 MFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTHVASAPASRAVVAQHVAPPPGIVEIDS 520
            |||||||.|||||||.||::|::||||||.:|.|.:..:..:.||:|.|.| |.|||||||||||
Frog   456 MFGPDALTAVKLIEHQSSNNQVVSEIRPQTVEHVPSPVNAGNVPATRPVPA-HAAPPPGIVEIDS 519

Human   521 EKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVED 585
            |||.||||||||||.||.||||:|||||||||||||||||||||:|||||||:||.||.:|||||
Frog   520 EKFGCQWLNAHFEVCPDSSVSRSEMYSEYLSTCSKLARGGILTSSGFYKCLRSVFANHNIKRVED 584

Human   586 SSSNGQAHIHVVGVKRRAIPLPIQMYYQQ-QPVSTSVVRVDSVPDVSPAPSPAGIPHGSQTIGNH 649
            .::||||||||.||:|||||||:|||||| ||  .||||||.|.||: ..:|:|:..|   :.||
Frog   585 PNNNGQAHIHVAGVRRRAIPLPVQMYYQQHQP--ASVVRVDVVSDVA-GKNPSGMQQG---VANH 643

Human   650 FQRTPVANQSSNLTATQMSFPVQGVHTVAQTVSRIPQNPSPHTHQQQNAPVTVIQSKAPIPCEVV 714
            |||...:||...|..||:|.|:||||||.       |||......|||..||:||:|.||.|| |
Frog   644 FQRVQASNQVPTLNTTQISLPIQGVHTVT-------QNPLSQVQHQQNPTVTLIQNKTPISCE-V 700

Human   715 KATVIQNSIPQTGVPVSIAVGGGPPQSSVVQNHS-TGPQ-PVTVVNSQTLLHHPSVIPQQSPLHT 777
            ||||||.|:|.:.||||||:|.. .|:|:||||| .|.| .||||.||.|.|||||:..||.||.
Frog   701 KATVIQGSVPHSSVPVSIALGSS-TQASIVQNHSGIGQQSSVTVVGSQALFHHPSVLQPQSALHA 764

Human   778 VVPGQIPSGTPVTVIQQAVPQSHMFGRVQNIPACTSTVSQGQQLITTSPQPVQTSSQQTSAGSQS 842
            ||||||.|||||.||||.|||.|:|||||||...:|.:||.|||:.||.|.||.:|||:.|.:|.
Frog   765 VVPGQITSGTPVAVIQQTVPQGHIFGRVQNISQGSSALSQAQQLVPTSSQTVQVTSQQSPASNQQ 829

Human   843 QDTVIIAPPQYVTTSASNIVSATSVQNFQVATGQMVTIAGVPSPQASRVGFQNIAPKPLPSQQVS 907
            :|||||.|.|||||::||||:||:|||||||.|.:||||||.:|||||:||||||||||.|||||
Frog   830 KDTVIITPQQYVTTTSSNIVTATTVQNFQVAPGHVVTIAGVQNPQASRIGFQNIAPKPLCSQQVS 894

Human   908 STVVQQPIQQPQQPTQQSVVIVSQPAQQGQTYAPAIHQIVLANPAALPAGQTVQLTGQPNITPSS 972
            ||||.|.:||.||  ||||||||||||.||.||||||||||||.||:..||||||.|||:|:|||
Frog   895 STVVPQTLQQQQQ--QQSVVIVSQPAQHGQAYAPAIHQIVLANTAAIQTGQTVQLPGQPSISPSS 957

Human   973 SPSPVPATNNQVPTAMSS-SSTPQSQGPPPTVSQMLSVKRQQQQQHSPAPP----------PQQV 1026
            | ||:|.||||:|..|:| .:||.||||||||||||||||||    |||||          |||.
Frog   958 S-SPMPTTNNQLPPLMTSPPTTPVSQGPPPTVSQMLSVKRQQ----SPAPPVTTPQQQAQVPQQT 1017

Human  1027 QVQVQQ--PQQVQMQV-QPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPN 1088
            |.|.||  |||||:|| |.||:.:|||.|..||||||||||||||||||||||||||||||||||
Frog  1018 QTQTQQQPPQQVQVQVQQQQQTTSGVGLPTPGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPN 1082

Human  1089 NARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQQNVQLVPSAMPPSGGVQTVPISNLQILPG 1153
            ||||||||:|||||:|||..||||||...||:||||||||||.||||....||||||||||||||
Frog  1083 NARAPSPQLVYQVANNQAPSFGVQGQPTPQQILVGQQNVQLVQSAMPNQTAVQTVPISNLQILPG 1147

Human  1154 PLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLPVQTLP 1218
            .|||||||||||||:|||||||||||||||.||||||.|.|:|||    ||||||||||.|||:|
Frog  1148 QLISNSPATIFQGTTGNQVTITVVPNTSFATATVSQGTAPQIIAP----MSGTQTGVGLQVQTIP 1208

Human  1219 ATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNTSNGDT 1283
            ||....||..|.:.|:|||||||||||||||||||||||||||||||||||||.:.:.|||||:|
Frog  1209 ATLTQSAGHLSGSAASPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCPKASANTSNGET 1273

Human  1284 KENEMHVGSLLNGRKYSDSSLPPSNSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQIDMQD 1348
            .|||:.:|:::||:|| |||||||||||.|.||:..||::||.|:||||||.|||||||..|||:
Frog  1274 NENEVQIGNIMNGKKY-DSSLPPSNSGKTQKETSSNSLVTNGSSVELGENGISGKQNSELTDMQE 1337

Human  1349 IKSDLRKPLVNGICDFDKGDGSHLSKNIPNHKTSNHVGNGEISPMEPQGTLDITQQDTAKGDQLE 1413
            .|.||:||.|||||||||.|||||||||||||.|||||||:|||:|.|..||.:|..||||||:|
Frog  1338 TKIDLKKPQVNGICDFDKADGSHLSKNIPNHKASNHVGNGDISPVEQQELLDSSQLVTAKGDQVE 1402

Human  1414 RISNGPVLTLGGSSVSSIQEASNAATQ-QFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSV 1477
            ::|||||||      :..|:|||.|.| :.:.|||.|||:.||||||||||||||:||..||.||
Frog  1403 KLSNGPVLT------NRAQDASNLAIQIRCNSTDLPNGPIVSSLNSDVPQQRPSVLVSTQSTASV 1461

Human  1478 IQGHQIIAVPDSGSKVSHSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTIS 1542
            :.|||:||.|.:|.:|| .|.||:|||.||||.:||||||||||.|||:|..|||||||||||||
Frog  1462 LPGHQVIAFPHTGQRVS-QPVLSADVRPTNGTTDCKTVKRPAEDNDRESVPVIPNKVGVRIVTIS 1525

Human  1543 DPNNAGCSATMVAVPAGADPSTVAKVAIESAVQQKQQHPPTYVQNVVPQNTPMPPSPAVQVQGQP 1607
            |||||||||||||||||.||||||||||||||.||||||.|:||.:|.|:||:...||:||||..
Frog  1526 DPNNAGCSATMVAVPAGVDPSTVAKVAIESAVHQKQQHPHTFVQTMVAQSTPVTTLPALQVQGHL 1590

Human  1608 NSSQPSPF--SGSSQPGDPMRKPGQNFMCLWQSCKKWFQTPSQVFYHAATEHGGKDVYPGQCLWE 1670
            .|||||||  :.|....:.::|||||||||||||||||:|||||||||||||||||||||||:||
Frog  1591 VSSQPSPFPVTTSVHHVEQVKKPGQNFMCLWQSCKKWFETPSQVFYHAATEHGGKDVYPGQCMWE 1655

Human  1671 GCEPFQRQRFSFITHLQDKHCSKDALLAGLKQDEPGQAGSQKSSTKQPTVGGTSSTPRAQKAIVN 1735
            ||||||||||||||||||||||:|||||||||:|.|.   ||.|.|||: .|.||||||||||||
Frog  1656 GCEPFQRQRFSFITHLQDKHCSRDALLAGLKQEEQGH---QKPSNKQPS-AGASSTPRAQKAIVN 1716

Human  1736 HPSAALMALRRGSRNLVFRDFTDEKEGPITKHIRLTAALILKNIGKYSECGRRLLKRHENNLSVL 1800
            ||||||||||||||||||||||||||||||||||||||||||||.|:||.|||.||||||.||.|
Frog  1717 HPSAALMALRRGSRNLVFRDFTDEKEGPITKHIRLTAALILKNIAKHSERGRRSLKRHENQLSFL 1781

Human  1801 AISNMEASSTLAKCLYELNFTVQSKEQEKDSEMLQ 1835
            |:|||||||||||||||||.|..||:||.|.||||
Frog  1782 ALSNMEASSTLAKCLYELNITSHSKDQETDFEMLQ 1816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARID2	NP_689854.2	ARID	19..101	CDD:279697	72/81 (89%)
		LXXLL	313..317		3/3 (100%)
		RFX_DNA_binding	521..601	CDD:280427	66/79 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..844		13/24 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..919		20/24 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..1057		66/108 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1266..1287		13/20 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1295..1314		15/18 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1321..1341		14/19 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1488..1522		22/33 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1572..1629		31/58 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1703..1728		12/24 (50%)
arid2	XP_017947767.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1672	1.000	Domainoid score	I171
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14601
Inparanoid	1	1.050	2554	1.000	Inparanoid score	I374
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47775
OrthoDB	1	1.010	-	-		D16480at32523
OrthoFinder	1	1.000	-	-		FOG0006621
OrthoInspector	1	1.000	-	-		oto155645
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4843
SonicParanoid	1	1.000	-	-		X5621
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.010