Protein Alignment ANO6 and subdued

DIOPT Version :10

• Sequence 1: NP_001191732.1
• Gene: ANO6 / 196527
• HGNCID: 25240
• Length: 931
• Species: Homo sapiens
• Sequence 2: NP_001189248.1
• Gene: subdued / 42340
• FlyBaseID: FBgn0038721
• Length: 1099
• Species: Drosophila melanogaster
• Alignment Length: 913
• Identity: 369/913 - (40%)
• Similarity: 513/913 - (56%)
• Gaps: 108/913 - (11%)

Human    55 PDL--GSLESQHDFR----TPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQ 113
            ||.  |::...:|.|    ..||.:......||||.|..|.|||||.|...:.:.|..:.|
  Fly   153 PDFVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAYRINAHEPTELENT---- 213

Human   114 RRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLK---------- 168
             .||:.:|:|||..||::|:::.   |::.|||:|||.|||..||||:.:::|:|
  Fly   214 -EKRRVFEANLISQGLEVESSQK---DQIWFVKIHAPLEVLRRYAEILKLRMPMKESLCNLRISE 274

Human   169 -PNDLKNRS------------------SAFGTL----NWFTKVLSVDESIIKPEQEFFTAPFEKN 210
             .|.|:|.:                  |.|.:|    .:|.:.:.|||.|.......|||.:.::
  Fly   275 RSNRLRNAAHYLTNKIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRD 339

Human   211 RMNDFYIVD--RDAFFNPATRSRIVYFILSRVKYQVIN-NVSKFGINRLVNSGIYKAAFPLHDCK 272
            :.   |:.|  :|.||..|.|||||.|||.|.::...| :...|||.||:..|:|.||:||||
  Fly   340 KE---YLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHD-- 399

Human   273 FRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVG 337
                .|.......|.|||:.||.....|:.||||.|::|:|.|||:|||||||||.|||||::||
  Fly   400 ----GEITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVG 460

Human   338 VACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVF 402
            |.||||.:.:..|....|::|... ...|.|||.|| .|.||.|..||..:|...:.|:..|:.|
  Fly   461 VICFLYSWFSLKNYVPVKDICQSG-NTNITMCPLCD-WCNFWDLKETCNYAKVTYLIDNPSTVFF 523

Human   403 AVFMGVWVTLFLEFWKRRQAELEYEWDTVELQ-QEEQARPEYEARCTHVV---INEITQ-EEERI 462
            ||||..|.|||||.|||..||:.:.||..... .||..||:|.||..|:.   ::.:|. :|..:
  Fly   524 AVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTV 588

Human   463 PFTAWGKCIRITLCA-SAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQ 526
            ||  |...:..|:.: |.|...|.|...:::.::|||:|:......       |..|:.......
  Fly   589 PF--WRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKV-------GASPMTTSSAIV 644

Human   527 TATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIA 591
            .||: :|:.::..::.|||.:|..:|..:|..|:.||||.:::|||:|::|.||||||:|.||||
  Fly   645 LATA-SAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIA 708

Human   592 FFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWI------ 650
            ||||||||:||: ...|..||.|||..||||.||..||.|||.||..:|.|.||.||..
  Fly   709 FFKGKFVGHPGE-YNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMFWRKVLA 772

Human   651 --MNLIGRFHRVSGSEKI-TPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLA 712
              :.|...|:.....:|. ..||.:|:.|...|..|||.|||||::|:||||:|||:|||||..|
  Fly   773 IQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFA 837

Human   713 LVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYY 777
            |:|||||:|:||.||.|..:|.|.::.:|||.|..|:..|..|:|:||..||||||||||||||
  Fly   838 LLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVY- 901

Human   778 WSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNP--YS---DLGNHTTCRYRDFRYPPG 837
             ...|...|     |::||:|.|||.|||.|       :|  ||   ||.|.|||||.|||.||.
  Fly   902 -RHYVNKQG-----TLDGYLNFTLSEFKVID-------SPTLYSLAGDLSNITTCRYTDFRLPPS 953

Human   838 HPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLL--H 900
            .|::|..:..::.::|.:|.|::|.|:.:..|...:.:.|||:|...:.:|:||.|:|.:::  .
  Fly   954 SPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQ 1018

Human   901 ENH 903
            |.|
  Fly  1019 EAH 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANO6	NP_001191732.1	Anoct_dimer	82..305	CDD:465044	89/258 (34%)
		Anoctamin	308..891	CDD:461349	262/602 (44%)
subdued	NP_001189248.1	Anoct_dimer	186..428	CDD:465044	89/258 (34%)
		Anoctamin	431..1007	CDD:461349	262/602 (44%)