Protein Alignment ANO6 and CG6938

DIOPT Version :10

• Sequence 1: NP_001191732.1
• Gene: ANO6 / 196527
• HGNCID: 25240
• Length: 931
• Species: Homo sapiens
• Sequence 2: NP_001261733.1
• Gene: CG6938 / 39362
• FlyBaseID: FBgn0036235
• Length: 1245
• Species: Drosophila melanogaster
• Alignment Length: 965
• Identity: 364/965 - (37%)
• Similarity: 545/965 - (56%)
• Gaps: 139/965 - (14%)

Human    40 LPSSLVLENLGQTIVPDLGS----------LESQH------------------------------ 64
            :|.:.:..:||..:.|.|||          :||.|
  Fly   239 IPGTAMRRSLGLNLSPTLGSADRVNQSYEVMESSHSNVLPDQFGYRQLIPTERKASDTASSVSGS 303

Human    65 ------------------DFRTPEFEEFNG-KPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTN 110
                              |.|....::..| .|:||.|.||:|::|.||.:|:|......:  ..
  Fly   304 YYGSRKASKSNSLGGESGDERRVSKQDREGLDPESLMFRDGRRKVDMVLAWEEEDLGVMTE--AE 366

Human   111 EKQRRKRQAYESNLICHGL--QLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLP------- 166
            .|:|..|:::..|||..||  :||......::|..|:|:|.||.:....||:|::|||
  Fly   367 AKRRDNRRSFMENLIKEGLEVELEDKSQSFNEKTFFLKIHLPWRLETRLAEVMNLKLPVKRFITI 431

Human   167 -LKPN-DLKN---RSSAFGTLNW--FTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFF 224
             :||: |.:|   |:..:....|  .||.:.:|:::::.|..|..|....|....|.:.||...|
  Fly   432 SVKPSWDEENVVLRNMQYWKDVWQRLTKKIQLDQTLLEGETTFKAATANGNPEEQFIVKDRATAF 496

Human   225 NPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLL 289
            ..|.||.:|..:|.|..:   :...:.||.||:|.|.|...||||:.::.| ........:|.:|
  Fly   497 TSAQRSLMVMQVLIRTPF---DESDRSGIRRLMNDGTYLGCFPLHEGRYDR-PHSSGISLDRRVL 557

Human   290 YREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGY--LNQDNCT 352
            |:.||||...||||||.|:|||:|:||.:||.|||:||:||:..||||..||:||.  |..::.|
  Fly   558 YQTWAHPSQWYKKQPLCLVRKYFGDKIALYFCWLGFYTEMLVYPAVVGTLCFIYGLATLESEDNT 622

Human   353 WSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFW 417
            .|||:|:....|.|.:||.||:.|.:.:|:.:|..|:...:||:..|:.||:||..|.|.|||.|
  Fly   623 PSKEICNEYGTGNITLCPLCDKACSYQRLSESCLFSRLTYLFDNPSTVFFAIFMSFWATTFLELW 687

Human   418 KRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPF-TAWGKCIRITLCASAVF 481
            ||:|:.|.:|||...:..:|:.|||:|...|...:|.:|:|:|  |: :.|.:.||..:..|||.
  Fly   688 KRKQSVLVWEWDLHNVDMDEENRPEFETNATTFRMNPVTREKE--PYMSTWNRSIRFVITGSAVL 750

Human   482 FWILLIIASVIGIIVYRLSV----------FIVFSAKLPKNINGTDPIQKYLTPQTATSITASII 536
            |.|.:::::|:|.|:||:::          |:...|||                  .||:||::|
  Fly   751 FMISVVLSAVLGTILYRITLVSVIYGGGGFFVKEHAKL------------------FTSVTAALI 797

Human   537 SFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYP 601
            :.::||||..||.::||.:||.|.|||.|:||:|.|.|:|.|:|:|:|||..|||||||:|..||
  Fly   798 NLVVIMILTRIYHRMAIKLTNLENPRTHTEYEDSYTFKIFFFEFMNFYSSLIYIAFFKGRFFDYP 862

Human   602 GDPVYWLGKY---RNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMN-LIGRFHRVSG 662
            ||......::   :|:.|||.|||.||..||.|||.||..|||..|.|.|...| ...|.|:.:.
  Fly   863 GDDQARKSEFFRLKNDICDPAGCLSELCIQLAIIMVGKQCWNNFMEYLFPKFWNWWRQRKHKQAT 927

Human   663 SEK--ITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAW 725
            .::  :...||||||:|..|:|.||.||||||:|:||||||||:||||||.||:||:.|||:||:
  Fly   928 KDESHLHMAWEQDYHMQDPGRLALFDEYLEMILQYGFVTLFVAAFPLAPLFALLNNVAEIRLDAY 992

Human   726 KLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTS 790
            |:.||.||.:.|:.:|||||..|::.|...|||:||.:||:|||.|||:||.:.:|       .:
  Fly   993 KMVTQARRPLAERVEDIGAWYGILRIITYTAVVSNAFVIAYTSDFIPRMVYKFVYS-------ET 1050

Human   791 YTMEGYINNTLSIFKVADFKNK-----SKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWH 850
            :|:.|||.::||||..:|:|.:     |:.:|       .||:||.:|..|...:.|..:.:|||
  Fly  1051 HTLAGYIEHSLSIFNTSDYKEEWGASVSEKDP-------DTCQYRGYRNGPKDYEPYGLSPHYWH 1108

Human   851 VIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLK 905
            |.||:|||::|.|||::.:...:.:.||||....|:::|||:.|.::..:::.:|
  Fly  1109 VFAARLAFVVVFEHVVFVITGIMQFIIPDVPSEVKTQMQREQLLAKEAKYQHGIK 1163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANO6	NP_001191732.1	Anoct_dimer	82..305	CDD:465044	77/238 (32%)
		Anoctamin	308..891	CDD:461349	264/606 (44%)
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:465044	77/238 (32%)
		Anoctamin	576..1149	CDD:461349	264/606 (44%)