Protein Alignment ANO6 and CG10353

DIOPT Version :10

• Sequence 1: NP_001191732.1
• Gene: ANO6 / 196527
• HGNCID: 25240
• Length: 931
• Species: Homo sapiens
• Sequence 2: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Alignment Length: 900
• Identity: 336/900 - (37%)
• Similarity: 507/900 - (56%)
• Gaps: 118/900 - (13%)

Human    83 FNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKV 147
            |:||:|.:||||.|..|::.        |:.|||.:.:|:||...|||||..:.   .::.|:|:
  Fly   183 FDDGKRSVDFVLAYNGETQL--------EEHRRKCEIFEANLQREGLQLEHNKV---QRVHFIKI 236

Human   148 HAPWEVLCTYAEIMHIKLPLKP---NDLKNRSSAFGTLNWFTKVL-SVDESI-----IKPEQEFF 203
            |||.|||..||||:.||:||||   .|.....||......|:::. |:..|:     :.||:|
  Fly   237 HAPAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTALFPERE-- 299

Human   204 TAP-----FEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY----QVINNVSKFGINRLVNS 259
              |     |.:|.: :.|..:...|.:.:||..|:.|||.|.::    :..:|:   ||.:||..
  Fly   300 --PRIHLEFSRNYL-ELYDTEHPNFLDASTRYSIINFILQRQRFVEGEETADNL---GIEKLVQD 358

Human   260 GIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLG 324
            |:|..|:.|||            .::|..|.:|||:.......||||.|:.|:|.|:.:||||||
  Fly   359 GVYTCAYTLHD------------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLG 411

Human   325 YYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSK 389
            :|||||:..:|.||.|||||::..::...|:::|  |..| .||||||||.|.:|:||.||.|||
  Fly   412 FYTQMLIPISVFGVLCFLYGFITWNSDPISRDIC--DDNG-TIMCPQCDRSCDYWRLNETCTSSK 473

Human   390 KLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWD-TVELQQEEQARPEYEARC--THVV 451
            ...:.|:..|:|||..|.:|..::||||||..|.|.:.|. |......|..||:|.||.  |..:
  Fly   474 FNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKL 538

Human   452 INEITQEEER---------IPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSA 507
            ..:..:::..         :||.::......|..:..|.|..:.:|| :.|||:||:      :.
  Fly   539 AGKAYEQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVIA-IAGIIIYRM------AQ 596

Human   508 KLPKNINGTDPIQKY---LTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYEN 569
            :...:|.|::....:   :.|     :||.||..|:|.:|:.:|..:|:.:||:|..||||:|:.
  Fly   597 RASHSILGSENSMTFKVMILP-----MTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDE 656

Human   570 SLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMG 634
            |||:|.::|||||||||.|||||.||||||||......|| :|.|||:|||||:||..||.|||.
  Fly   657 SLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLG-FRQEECNPGGCLMELCMQLVIIMA 720

Human   635 GKAIWNNIQEVLLPWIMNLIGR------FHRVSGSEKITP--RWEQDYHLQPMGKLGLFYEYLEM 691
            ||...|.|.|:|:|::|.....      :::....:::.|  ::.:||:|.|.....|:.|||||
  Fly   721 GKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEM 785

Human   692 IIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILA 756
            ::||||:|||..:|||||||||:||::|:|:||.|:....||.|..:|:|||.|..||..:..:|
  Fly   786 VVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIA 850

Human   757 VVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDL 821
            |.::||||||::::||::||..|...|        .:..|:|.||::|...||:.:..      |
  Fly   851 VASSAMIIAFSTNLIPKIVYAASMGDP--------ELNNYLNFTLAVFNTKDFQVQPL------L 901

Human   822 G-----NHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVS 881
            |     |.|.|||.:||..|..|..||..:.||.::..:||||::.:::|..::..:.:|:||||
  Fly   902 GGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVS 966

Human   882 KRTKSKIQREKYLTQK-----------LLHENHLKDMTKNMGVIAERMIEAVDNN 925
            .|...:|:||.:|.::           .|.:..|....|:.|.:.:|..|.|..|
  Fly   967 GRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGELRQRNNETVIRN 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANO6	NP_001191732.1	Anoct_dimer	82..305	CDD:465044	78/239 (33%)
		Anoctamin	308..891	CDD:461349	244/610 (40%)
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	78/239 (33%)
		Anoctamin	395..976	CDD:461349	244/610 (40%)