DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbl1 and Rbf2

DIOPT Version :9

Sequence 1:	NP_035379.2	Gene:	Rbl1 / 19650	MGIID:	103300	Length:	1063	Species:	Mus musculus
Sequence 2:	NP_524372.1	Gene:	Rbf2 / 41941	FlyBaseID:	FBgn0038390	Length:	783	Species:	Drosophila melanogaster

Alignment Length:	1062	Identity:	222/1062 - (20%)
Similarity:	381/1062 - (35%)	Gaps:	352/1062 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 EGAAAVAAAREALQALCQELNLD---EGSAAEALDDFTAIRGNYSLEGEVIHWLACSLYVACRKS 70
            ||.|.....|.::.  |::|.|:   :.||........|:.|..:.|.:...||.|::|...::|
  Fly     7 EGEAETLVRRFSVS--CEQLELEARIQQSALSTYHRLDAVNGLSTSEADAQEWLCCAVYSELQRS 69

Mouse    71 IIPTVGKGVMEGN-------C--VSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLE 126
            .:..:.:.:.|.|       |  |||||:|||.|:::.||..:|:.|..::.....|:..:|.|.
  Fly    70 KMRDIRESINEANDSVAKNCCWNVSLTRLLRSFKMNVSQFLRRMEHWNWLTQNENTFQLEVEELR 134

Mouse   127 RNFEVSTVIFKKFEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMI 191
            ....:::.:.:.::.||..:|.:|.:.......:..|.        |:.|.|.||:..:......
  Fly   135 CRLGITSTLLRHYKHIFRSLFVHPGKGADPGAANHYQA--------LYEFGWLLFLVIRNELPGF 191

Mouse   192 G-DDLVNSYHLLLCCLDLIFANAIMCPNRRDLLNPSFKGLPSDFHAPDFKAAEEPPCII---AVL 252
            . .:|:|...:|:|.:||:|.||:..| |..::...|.|:|.::...||.     |.::   :||
  Fly   192 AITNLINGCQVLVCTMDLLFVNALEVP-RSVVIRREFSGVPKNWDTEDFN-----PILLNKYSVL 250

Mouse   253 CDLHDGLLVE--AKGI---KEHYF-KPYISKLFD----------KKILKGECLLDLSSFTDNSKA 301
            ..|.: |:.|  |||:   |..:| |..|....|          ::|:| |.:||:     |.:.
  Fly   251 EALGE-LIPELPAKGVVQMKNAFFHKALIMLYMDHSLVGDDTHMREIIK-EGMLDI-----NLEN 308

Mouse   302 VNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTADTPFGKLTSQASVECNLQQHFEKKRSFA 366
            :|::|...|..:.:.|||:.|..                       |.::|.........:.:|.
  Fly   309 LNRKYTNQVADISEMDERVLLSV-----------------------QGAIETKGDSPKSPQLAFQ 350

Mouse   367 PSTPLTGRRYLQEKEAVTTPVASATQSVSRLQSIVAGLKSAPSEQLLNIFESCMRNPMGNIIKIV 431
            .|:..:.|:........:.|          |..|.|..|...:::::|..:..:..
  Fly   351 TSSSPSHRKLSTHDLPASLP----------LSIIKAFPKKEDADKIVNYLDQTLEE--------- 396

Mouse   432 KGIGETFCQHYTQSTDKQPGSHIDFAVNRLKLAEILYYKILETIMVQETRRLHGMDMSVLLEQDI 496
              :..||........|      .:.:..|.:.|..||||.|:.|:..|..:...:.:..|::|..
  Fly   397 --MNRTFTMAVKDFLD------AELSGKRFRQARGLYYKYLQKILGPELVQKPQLKIGQLMKQRK 453

Mouse   497 FHKSLMACCLEIVLFAYS---SPRTFPWIIEVLDLQPFYFYKVIEVVIRSEEG-LSRDMVKHLNS 557
            ...:|:|||||:.|..:.   ....||:::....|..:.|.|::|:|:|.:.| |.|:::|||:.
  Fly   454 LTAALLACCLELALHVHHKLVEGLRFPFVLHCFSLDAYDFQKILELVVRYDHGFLGRELIKHLDV 518

Mouse   558 IEEQILESLAWTNNSALWEALHASANRVPSCEEVIFPNNFEIGNGGNVQGHLPMMPMSPIIHPRV 622
            :||..|:||.:..:|.||..|:...                                     ||.
  Fly   519 VEEMCLDSLIFRKSSQLWWELNQRL-------------------------------------PRY 546

Mouse   623 KEVRTDSGSLRQDMQPLSPISVHERYSSPAAGSAKRRLFGDDPPKDTLMDKIMAEGTKLKIAPSS 687
            |||..::    :|.:..|
  Fly   547 KEVDAET----EDKENFS----------------------------------------------- 560

Mouse   688 VTAESLSISPGQALLTMATTTVTGTTGRKVTVPLHGIANDAGEITLVPISMNPTQESTAESPVSL 752

  Fly   561 ----------------------------------------------------------------- 560

Mouse   753 TAQSLIGTSPKQTHLTKAQDAHLTGVSKPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRR 817
                                           ||| ::..||.|.||:.||..||..|.:.:.. .
  Fly   561 -------------------------------TGS-SICLRKFYGLANRRLLLLCKSLCLVDSF-P 592

Mouse   818 KIWTCFE--FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRS 880
            :||...|  ||| ....|:::||||||||||.::..::.|...||..|::.||.||......||.
  Fly   593 QIWHLAEHSFTL-ESSRLLRNRHLDQLLLCAIHLHVRLEKLHLTFSMIIQHYRRQPHFRRSAYRE 656

Mouse   881 VLLKSIPGGVVVYNGDCEMTDGDIEDATKTPNCSSEPVKEERGDLIKFYNTVYVGRVKSF----- 940
            |.|.         ||                         :..|:|.|||:|||..:.::
  Fly   657 VSLG---------NG-------------------------QTADIITFYNSVYVQSMGNYGRHLE 687

Mouse   941 ------ALKYDLSNQDHIMD--APPLSPFPHIKQQPGSPRRISQQHSLYVSPHKNGAGLTPRSAL 997
                  :|:...||...:.:  :..||...:|......|.|:.|..|....|..:.|. :|.|
  Fly   688 CAQTRKSLEESQSNVGILTETTSNELSMRANISISSPPPPRVCQSGSCSSHPPSSPAA-SPLS-- 749

Mouse   998 LYKFNGSPS-KSLKDINNMIRQ 1018
               ...||: |.....|:::|:
  Fly   750 ---LQSSPNVKRAASSNDLMRE 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbl1	NP_035379.2	DUF3452	77..209	CDD:288762	34/141 (24%)
		Pocket, binds T and E1A. /evidence=ECO:0000250\|UniProtKB:P28749	383..944		110/577 (19%)
		Domain A. /evidence=ECO:0000305	383..584		50/204 (25%)
		RB_A	385..578	CDD:280101	49/196 (25%)
		Spacer. /evidence=ECO:0000305	585..779		7/193 (4%)
		Domain B. /evidence=ECO:0000305	780..944		53/176 (30%)
		RB_B	786..937	CDD:280100	50/152 (33%)
		Rb_C	956..>1041	CDD:286075	16/64 (25%)
Rbf2	NP_524372.1	DUF3452	83..210	CDD:288762	32/134 (24%)
		RB_A	380..536	CDD:280101	42/172 (24%)
		CYCLIN	564..679	CDD:294043	49/150 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7132
OMA	1	1.010	-	-		QHG46367
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	1	1.000	-	-		FOG0002362
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770